473 research outputs found

    Fractional quantum Hall states as an Abelian group

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    We show that the set of double-layer Fractional Quantum Hall (FQH) states with a given topological order form a finite Abelian group under a new product. This group structure makes it possible to construct new FQH states from known ones. We also introduce a new index which can be used to characterize the topological order of FQH states.Comment: 9 page

    Generalized Uncertainty Principle as a Consequence of the Effective Field Theory

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    We will demonstrate that the generalized uncertainty principle exists because of the derivative expansion in the effective field theories. This is because, in the framework of the effective field theories, the minimum measurable length scale has to be integrated away to obtain the low energy effective action. We will analyze the deformation of a massive free scalar field theory by the generalized uncertainty principle, and demonstrate that the minimum measurable length scale corresponds to a second more massive scale in the theory, which has been integrated away. We will also analyze CFT operators dual to this deformed scalar field theory, and observe that scaling of the new CFT operators indicates that they are dual to this more massive scale in the theory. We will use holographic renormalization to explicitly calculate the renormalized boundary action with counterterms for this scalar field theory deformed by the generalized uncertainty principle and show that the generalized uncertainty principle contributes to the matter conformal anomaly.Comment: 15 pages, no figures, Accepted for Publication in Physics Letters

    Aspects of moduli stabilization in type IIB string theory

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    We review moduli stabilization in type IIB string theory compactification with fluxes. We focus on the KKLT and Large Volume Scenario (LVS). We show that the predicted soft SUSY breaking terms in KKLT model are not phenomenological viable. In LVS, the following result for scalar mass, gaugino mass, and trilinear term is obtained: m0=m1/2=A0=m3/2m_0 =m_{1/2}= - A_0=m_{3/2}, which may account for Higgs mass limit if m3/2O(1.5)m_{3/2} \sim {\cal O}(1.5) TeV. However, in this case the relic abundance of the lightest neutralino can not be consistent with the measured limits. We also study the cosmological consequences of moduli stabilization in both models. In particular, the associated inflation models such as racetrack inflation and K\"ahler inflation are analyzed. Finally the problem of moduli destabilization and the effect of string moduli backreaction on the inflation models are discussed.Comment: 34 pages, 8 figure

    Characterization of aggresome formation in choroid plexus carcinoma.

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    Protein misfolding is inevitable, 30% of newly synthesized polypeptides can end up misfolded, and such proteins are either refolded or eliminated by cellular quality control pathways. These pathways include the ubiquitin proteosome system and autophagy. In recent years, protein misfolding has been implicated in the pathophysiology of many diseases such as diabetes, neurological disorders and cancer. Studies from our laboratory have shown that choroid plexus carcinoma tumors are characterized by the formation of aggresomes at the microtubules organizing centers (MTOC) in formalin fixed and paraffin embedded (FFPE) tumor tissues. This was further confirmed by the development of choroid plexus carcinoma cell line (CCHE-45) which was characterized by the constitutive formation of aggresomes at MTOC. Aggresome formation implies presence of toxic protein over load and/or defective autophagy. The role of autophagic flux in the removal of aggresomes was further investigated. CCHE-45 cells displayed an increase in both basal and induced autophagic flux. Furthermore, microtubule-associated protein light chain 3 A- variant 1 (LC3A-V1) expression was silenced by promoter methylation in these cells. Restoring LC3A-V1 resulted in the elimination of the aggresomes and the recruitment of Lysosomal-Associated Membrane Protein (LAMP2) independent from autophagosome formation. Based on these findings we suggest that quality control autophagy in CCHE-45 is mediated by LC3A in aggresomes clearance. We propose that perturbation in the autophagic pathway by the absence of LC3A expression leads to a failure in aggresome degradation thus overcoming misfolded protein overload

    Factors Affecting the Implementation of Electronic Medical Records Systems (EMRs) in Jordanian Hospitals

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    An Electronic Medical Record System (EMRS) is an application that enables access and retrieval of a patient's medical history. Currently EMRS implementation does not encompass more than 50% of the hospitals in Jordan, and limited research has been done in Jordan to identify the main factors affecting the implementation of EMRS. The aim of this study is to explore the factors that affect the EMRS implementation in Jordanian hospitals. A conceptual model, adapted from Technology Acceptance Model (TAM), was built to relate Organizational Factors (OF) and Individual Characteristic Factors (ICF) to EMRS implementation in Jordanian hospitals. Self-administered questionnaires were used to collect the data from healthcare professionals in two major hospitals that have full implementation of EMRS. Findings indicated that OF has significant relationships with Perceived Ease of Use (PEOU) and Perceived Usefulness (PU), ICF has significant relationships with PEOU, User-Patient relationship has significant relationships with PU with exception of User Autonomy, PEOU has a significant effects with PU, PU has significant relationship with Attitude Toward Using (ATU) exception of PEOU, and ATU has a significant relationship with Behavioural Intention to Use. The finding of this study has led to the enhancement of the theoretical knowledge of TAM'S application in the health informatics domain. This study has extended the current model comprising PEOU and PU, by adding the OF and ICF. Consequently, the findings can assist decision makers in formulating EMRS implementation strategies in Jordan

    Kienböck’s disease: a case report

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    Kienböck disease is a condition characterized by avascular necrosis of the lunate bone. Advanced imaging can aid in the diagnosis and staging of Kienböck disease. Magnetic resonance imaging (MRI) is an important adjunct to diagnosis. In particular, MRI is helpful early in the disease when plain radiographs may not reveal abnormalities. A 17 -year-old man with Kienböck disease who underwent radiography and MR is described in this article.Pan African Medical Journal 2015; 2