20 research outputs found

    Educomunicação e suas áreas de intervenção: Novos paradigmas para o diálogo intercultural

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    oai:omp.abpeducom.org.br:publicationFormat/1O material aqui divulgado representa, em ess√™ncia, a contribui√ß√£o do VII Encontro Brasileiro de Educomunica√ß√£o ao V Global MIL Week, da UNESCO, ocorrido na ECA/USP, entre 3 e 5 de novembro de 2016. Estamos diante de um conjunto de 104 papers executivos, com uma m√©dia de entre 7 e 10 p√°ginas, cada um. Com este rico e abundante material, chegamos ao s√©timo e-book publicado pela ABPEducom, em seus seis primeiros anos de exist√™ncia. A especificidade desta obra √© a de trazer as ‚Äú√Āreas de Interven√ß√£o‚ÄĚ do campo da Educomunica√ß√£o, colocando-as a servi√ßo de uma meta essencial ao agir educomunicativo: o di√°logo intercultural, trabalhado na linha do tema geral do evento internacional: Media and Information Literacy: New Paradigms for Intercultural Dialogue

    ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest

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    Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ

    Inferences about the global scenario of human T-cell lymphotropic virus type 1 infection using data mining of viral sequences

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    Human T-cell lymphotropic virus type 1 (HTLV-1) is mainly associated with two diseases: tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) and adult T-cell leukaemia/lymphoma. This retrovirus infects five-10 million individuals throughout the world. Previously, we developed a database that annotates sequence data from GenBank and the present study aimed to describe the clinical, molecular and epidemiological scenarios of HTLV-1 infection through the stored sequences in this database. A total of 2,545 registered complete and partial sequences of HTLV-1 were collected and 1,967 (77.3%) of those sequences represented unique isolates. Among these isolates, 93% contained geographic origin information and only 39% were related to any clinical status. A total of 1,091 sequences contained information about the geographic origin and viral subtype and 93% of these sequences were identified as subtype ‚Äúa‚ÄĚ. Ethnicity data are very scarce. Regarding clinical status data, 29% of the sequences were generated from TSP/HAM and 67.8% from healthy carrier individuals. Although the data mining enabled some inferences about specific aspects of HTLV-1 infection to be made, due to the relative scarcity of data of available sequences, it was not possible to delineate a global scenario of HTLV-1 infection

    Molecular study of HBZ and gp21 human T cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals.

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    Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-06-04T12:54:34Z No. of bitstreams: 1 Mota-Miranda ACA Molecular study of HBZ....pdf: 136604 bytes, checksum: 7ba88357a68622e23fedaa32936ce20e (MD5)Made available in DSpace on 2014-06-04T12:54:34Z (GMT). No. of bitstreams: 1 Mota-Miranda ACA Molecular study of HBZ....pdf: 136604 bytes, checksum: 7ba88357a68622e23fedaa32936ce20e (MD5) Previous issue date: 2013Funda√ß√£o Oswaldo Cruz. Centro de Pesquisa Gon√ßalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Sa√ļde P√ļblica. Salvador, BA, Brasil /Universidade Federal da Bahia. Instituto de Ci√™ncias da Sa√ļde. Salvador, BA, BrasilFunda√ß√£o Oswaldo Cruz. Centro de Pesquisa Gon√ßalo Moniz. Salvador, BA, BrasilFunda√ß√£o Oswaldo Cruz. Centro de Pesquisa Gon√ßalo Moniz. Salvador, BA, BrasilFunda√ß√£o Oswaldo Cruz. Centro de Pesquisa Gon√ßalo Moniz. Salvador, BA, BrasilFunda√ß√£o Oswaldo Cruz. Centro de Pesquisa Gon√ßalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Sa√ļde P√ļblica. Salvador, BA, Brasil /Universidade Federal da Bahia. Instituto de Ci√™ncias da Sa√ļde. Salvador, BA, BrasilFunda√ß√£o Oswaldo Cruz. Centro de Pesquisa Gon√ßalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Sa√ļde P√ļblica. Salvador, BA, BrasilFunda√ß√£o Oswaldo Cruz. Centro de Pesquisa Gon√ßalo Moniz. Salvador, BA, BrasilHuman T cell leukemia virus type 1 (HTLV-1) is associated with a neurological syndrome named tropical spastic paraparesis/HTLV-associated myelopathy (TSP/HAM) and the disease progression involves viral factors. The gp21 glycoprotein is involved in envelope trafficking and membrane targeting while the bZIP protein is indispensable for cell growth and proliferation. This study aimed to assess the molecular diversity of gp21 and HBZ proteins in TSP/HAM and healthy carriers. DNA samples from HTLV-1-infected individuals were submitted to PCR and sequencing, and the molecular analyses were performed using bioinformatics tools. From eight gp21-analyzed sequences one amino acid change (Y477H) was associated with the switch of a helix to coil structure at secondary structure prediction. From 10 HBZ analyzed sequences, two amino acid changes were identified (S9P and T95I) at the activation domain. One mutation (R112C) located at the nuclear localization signal was present in 66.7% and 25% of healthy carriers (HC) and TSP/HAM groups, respectively. This is the first report of mutations in the HBZ region. These polymorphisms might be important for viral fitness

    Human retrovirus codon usage from tRNA point of view: therapeutic insights

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    Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-11-13T16:24:23Z No. of bitstreams: 1 Frias D.G. Human.pdf: 1564997 bytes, checksum: f165a32def8564d25b1536d70bad953f (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2014-11-13T16:24:34Z (GMT) No. of bitstreams: 1 Frias D.G. Human.pdf: 1564997 bytes, checksum: f165a32def8564d25b1536d70bad953f (MD5)Made available in DSpace on 2014-11-13T16:37:27Z (GMT). No. of bitstreams: 1 Frias D.G. Human.pdf: 1564997 bytes, checksum: f165a32def8564d25b1536d70bad953f (MD5) Previous issue date: 2013Bahia State University. Salvador, BA, BrasilFederal University of Bahia. Salvador, BA, Brasil / Bahia Schoolof Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, BrasilFederal University of Bahia. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, BrasilBahia State University. Salvador, BA, BrasilUniversity of KwaZulu-Natal. Africa Centre for Health and Population Studies. Doris Duke Medical Research Institute. Nelson Mandela School of Medicine. College of Health Sciences. Durban, South AfricaBahia Schoolof Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / Funda√ß√£o Oswaldo Cruz. Centro de Pesquisas Gon√ßalo Moniz. Salvador, BA, BrasilFunda√ß√£o Oswaldo Cruz. Centro de Pesquisas Gon√ßalo Moniz. Salvador, BA, BrasilThe purpose of this study was to investigate the balance between transfer ribonucleic acid (tRNA) supply and demand in retrovirus-infected cells, seeking the best targets for antiretroviral therapy based on the hypothetical tRNA Inhibition Therapy (TRIT). Codon usage and tRNA gene data were retrieved from public databases. Based on logistic principles, a therapeutic score (T-score) was calculated for all sense codons, in each retrovirus-host system. Codons that are critical for viral protein translation, but not as critical for the host, have the highest T-score values. Theoretically, inactivating the cognate tRNA species should imply a severe reduction of the elongation rate during viral mRNA translation. We developed a method to predict tRNA species critical for retroviral protein synthesis. Four of the best TRIT targets in HIV-1 and HIV-2 encode Large Hydrophobic Residues (LHR), which have a central role in protein folding. One of them, codon CUA, is also a TRIT target in both HTLV-1 and HTLV-2. Therefore, a drug designed for inactivating or reducing the cytoplasmatic concentration of tRNA species with anticodon TAG could attenuate significantly both HIV and HTLV protein synthesis rates. Inversely, replacing codons ending in UA by synonymous codons should increase the expression, which is relevant for DNA vaccine desig

    Re-mapping the molecular features of the human immunodeficiency virus type 1 and human T-cell lymphotropic virus type 1 Brazilian sequences using a bioinformatics unit established in Salvador, Bahia, Brazil, to give support to the viral epidemiology studies

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    The analysis of genetic data for human immunodeficiency virus type 1 (HIV-1) and human T-cell lymphotropic virus type 1 (HTLV-1) is essential to improve treatment and public health strategies as well as to select strains for vaccine programs. However, the analysis of large quantities of genetic data requires collaborative efforts in bioinformatics, computer biology, molecular biology, evolution, and medical science. The objective of this study was to review and improve the molecular epidemiology of HIV-1 and HTLV-1 viruses isolated in Brazil using bioinformatic tools available in the Laborat√≥rio Avan√ßado de S√°ude P√ļblica (Lasp) bioinformatics unit. The analysis of HIV-1 isolates confirmed a heterogeneous distribution of the viral genotypes circulating in the country. The Brazilian HIV-1 epidemic is characterized by the presence of multiple subtypes (B, F1, C) and B/F1 recombinant virus while, on the other hand, most of the HTLV-1 sequences were classified as Transcontinental subgroup of the Cosmopolitan subtype. Despite the high variation among HIV-1 subtypes, protein glycosylation and phosphorylation domains were conserved in the pol, gag, and env genes of the Brazilian HIV-1 strains suggesting constraints in the HIV-1 evolution process. As expected, the functional protein sites were highly conservative in the HTLV-1 env gene sequences. Furthermore, the presence of these functional sites in HIV-1 and HTLV-1 strains could help in the development of vaccines that pre-empt the viral escape process
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