3 research outputs found

    Análise Mecânica dos Estudos 1–5 de Ernesto García de León

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    Trabalho de Conclusão de Curso apresentado ao Instituto Latino-Americano de Arte, Cultura e História da Universidade Federal da Integração Latino-Americana, como requisito parcial à obtenção do título de Bacharel em Música.Este trabalho tem como principal objetivo realizar uma análise de recursos mecânicos dos Estudos de 1–5 para violão solo de Ernesto García de León (2002). Para isso, primeiramente, apresentamos uma breve biografia do compositor e um panorama sobre a concepção e função da obra em si. No capítulo seguinte, introduzimos definições de recursos mecânicos relevantes para a compreensão das análises desenvolvidas sobre o objeto de estudo deste trabalho. Por último, realizamos as análises individuais de cada estudo, buscando discutir em detalhe os recursos relevantes para a execução. As análises são acompanhadas de exercícios desenvolvidos a partir de particularidades dos estudos, propostos com o intuito de contribuir para o desenvolvimento de recursos mecânicos específicos

    Immune Response Gaps Linked to SARS-CoV-2 Infection: Cellular Exhaustion, Senescence, or Both?

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    The COVID-19 pandemic, promoted by the SARS-CoV-2 respiratory virus, has resulted in widespread global morbidity and mortality. The immune response against this pathogen has shown a thin line between protective effects and pathological reactions resulting from the massive release of cytokines and poor viral clearance. The latter is possibly caused by exhaustion, senescence, or both of TCD8+ cells and reduced activity of natural killer (NK) cells. The imbalance between innate and adaptive responses during the early stages of infection caused by SARS-CoV-2 contributes to the ineffective control of viral spread. The present study evaluated the tissue immunoexpression of the tissue biomarkers (Arginase-1, CCR4, CD3, CD4, CD8, CD20, CD57, CD68, CD138, IL-4, INF-α, INF-γ, iNOS, PD-1, Perforin and Sphingosine-1) to understand the cellular immune response triggered in patients who died of COVID-19. We evaluated twenty-four paraffin-embedded lung tissue samples from patients who died of COVID-19 (COVID-19 group) and compared them with ten lung tissue samples from patients who died of H1N1pdm09 (H1N1 group) with the immunohistochemical markers mentioned above. In addition, polymorphisms in the Perforin gene were genotyped through Real-Time PCR. Significantly increased tissue immunoexpression of Arginase, CD4, CD68, CD138, Perforin, Sphingosine-1, and IL-4 markers were observed in the COVID-19 group. A significantly lower immunoexpression of CD8 and CD57 was also found in this group. It is suggested that patients who died from COVID-19 had a poor cellular response concerning viral clearance and adaptive response going through tissue repair
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