1,811 research outputs found

    Search for the SM Higgs Boson Produced in Association with a Vector Boson and Decaying to Bottom Quarks

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    A search for the Higgs boson produced in association with a W or Z boson and decaying to bottom quarks is presented. A sample of approximately 24/fb of data recorded by the CMS experiment at the Large Hadron Collider, operating at center-of-mass energies of 7 TeV and 8 TeV in 2011 and 2012, respectively, is used to search for events consistent with the signature of two b jets recoiling with high momentum from a W(lnu), Z(ll), or Z(nunu) decay, where l = electron or muon (or hadronically-decaying tau particle in the case of W bosons). Observed signal significance and 95% confidence level upper limits on the production cross section relative to the Standard Model prediction are presented for the 110-135 GeV Higgs mass range.Comment: 8 pages, 3 figures. Presentation at the DPF 2013 Meeting of the American Physical Society Division of Particles and Fields, Santa Cruz, California, August 13-17, 201

    Should All Shock Centers Offer ECPR? Balancing Futility, Cost Effectiveness, and Hope

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    There are over 400,000 out-of-hospital cardiac arrests (OHCA) in the United States annually. Of those, 50% are refractory cardiac arrest, defined as the lack of return of spontaneous circulation (ROSC) after 30 minutes of appropriate cardiopulmonary resuscitation (CPR) in the absence of hypothermia. Extracorporeal cardiopulmonary resuscitation (ECPR) has been increasingly used given its potential to improve survival and offer improved neurological outcomes

    Information graphics: A Guidebook to downtown Rochester, New York

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    The Relationship Between Stress, Preventive Coping Resources, and Burnout Among Elementary Teachers

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    This study explored the relationship between stress outcomes, preventive coping, and burnout in a sample of 68 elementary teachers. Teacher training in behavioral modification was also examined due to its established role in teacher stress. Results showed that teachers who had greater demands relative to coping resources were more likely to experience two aspects of burnout; emotional exhaustion and depersonalization. A significant relationship was not found with the third component of burnout, personal accomplishment. Preventive coping resources were found to be associated in the expected direction with all three components of burnout. Those individuals with fewer preventive coping resources exhibited more symptoms of burnout, with more emotional exhaustion, depersonalization, and lowered personal accomplishment. Contrary to predictions, the relationship between stress predictions and burnout was not moderated by the influence of preventive coping among this sample


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    An analog pistol lock that stays attached to the pistol at all times, for in-home defense and unwanted user firearm discharg

    The Impact Of Neonatal Pain And Reduced Maternal Care On Brain And Behavioral Development

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    In the neonatal intensive care unit (NICU) preterm infants are exposed to a multitude of stressors, which include both neonatal pain and reduced maternal care. Clinical and preclinical research has demonstrated that exposure to neonatal pain and reduced maternal care has a profound negative impact on brain and behavioral development. Currently, the biological mechanism by which both of these stressors impacts brain and behavioral outcomes remains widely unknown. To uncover a potential biological mechanism, the current dissertation project utilized a preclinical model of repetitive needle pokes and developed a novel model of reduced maternal care through tea-ball encapsulation. Briefly, rat pups were separated into one of five groups: touch control, isolation and touch, pain, pain and isolation, and unhandled controls. Pups in the isolation conditions were enclosed in tea-ball infusers from postnatal day (PD) 1-4, four times a day for 30 minutes. Pups in pain conditions experienced repetitive needle pokes into alternating paws starting on PD1 and ending on PD4. Unhandled control pups were left undisturbed throughout each experiment. For experiment 1, pups were sacrificed immediately after the last tea-ball exposure on PD4 and serum corticosterone and various brain metabolites were analyzed. We observed a significant increase in serum corticosterone on PD4 in maternally isolated animals and a non-significant increase in pain exposed animals. Further, glutamate/creatine ratios were reduced in the frontal cortex and hippocampus in pain and maternally isolated animals respectively. For experiment 2, pups matured into adulthood and affective and cognitive behaviors were assessed through the open field test, novel object recognition test, Morris water maze, and restraint stress testing. During the Morris water maze, pain exposed animals displayed accelerated learning but both stressors impaired long-term memory. Moreover, reversal learning was enhanced in male isolated animals compared to touch males and isolated females. Finally, female pain exposed animals displayed impaired HPA-axis recovery following an acute stressor. Collectively, these studies demonstrate that both neonatal pain and reduced maternal care are potent neonatal stressors and can influence neonatal neurochemistry and adult cognitive and HPA-axis functioning. These findings highlight the need of interventions mitigating neonatal stress in the NICU
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