7,992 research outputs found

    Collections for people: museums' stored collections as a public resource

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    Collections in UK museums grew enormously in the latter half of the 20th century yet museum collections, mostly maintained at public expense, are perceived as an underused resource. The Museums Association’s 2005 report, Collections for the Future1, together with press comments and books such as Treasures on Earth (2002)2 and Fragments of the World (2005)3, brought this issue into sharp focus. Collections for People set out to understand the scale of museum stored collections, and the main parameters of their access and use: • What is the size and nature of collections as a resource? How are they distributed, geographically and among different types of museum? • How much are different types of collection used by people other than museum staff? What sort of people use collections? What do they use them for: research, teaching and learning, creative activities, visits for enjoyment such as store tours? • How do users perceive this service? Do museums actively market collections access? Do they publicise what is in their collections? • How do museums facilitate collections use? What are the factors associated with greater use of collections? What do museums see as the barriers to more use

    Exploring the mechanism of formation of native-like and precursor amyloid oligomers for the native acylphosphatase from Sulfolobus solfataricus

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    Over 40 human diseases are associated with the formation of well-defined proteinaceous fibrillar aggregates. Since the oligomers precursors to the fibrils are increasingly recognized to be the causative agents of such diseases, it is important to elucidate the mechanism of formation of these early species. The acylphosphatase from Sulfolobus solfataricus is an ideal system as it was found to form, under conditions in which it is initially native, two types of prefibrillar aggregates: (1) initial enzymatically active aggregates and (2) oligomers with characteristics reminiscent of amyloid protofibrils, with the latter originating from the structural reorganization of the initial assemblies. By studying a number of protein variants with a variety of biophysical techniques, we have identified the regions of the sequence and the driving forces that promote the first aggregation phase and show that the second phase consists in a cooperative conversion involving the entire globular fol

    Intramyocardial hemorrhage: An enigma for cardiac MRI?

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    Cardiovascular magnetic resonance (CMR) is a useful noninvasive technique for determining the presence of microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH), frequently occurring in patients after reperfused myocardial infarction (MI). MVO, or the so-called no-reflow phenomenon, is associated with adverse ventricular remodeling and a poor prognosis during follow-up. Similarly, IMH is considered a severe damage after revascularization by percutaneous primary coronary intervention (PPCI) or fibrinolysis, which represents a worse prognosis. However, the pathophysiology of IMH is not fully understood and imaging modalities might help to better understand that phenomenon. While, during the past decade, several studies examined the distribution patterns of late gadolinium enhancement with different CMR sequences, the standardized CMR protocol for assessment of IMH is not yet well established. The aim of this review is to evaluate the available literature on this issue, with particular regard to CMR sequences. New techniques, such as positron emission tomography/magnetic resonance imaging (PET/MRI), could be useful tools to explore molecular mechanisms of the myocardial infarction healing process

    Adiabatic Evolution for Systems with Infinitely many Eigenvalue Crossings

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    We formulate an adiabatic theorem adapted to models that present an instantaneous eigenvalue experiencing an infinite number of crossings with the rest of the spectrum. We give an upper bound on the leading correction terms with respect to the adiabatic limit. The result requires only differentiability of the considered spectral projector, and some geometric hypothesis on the local behaviour of the eigenvalues at the crossings
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