579 research outputs found

    Reflexiones Antropológicas sobre la Medicalización

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    Schmerz, chronische Krankheiten und Sterben kann aus anderen Blickwinkeln untersucht werden, als dem des biomedizinischen Modells, den Perspektiven und Modellen der Psychologie, der Palliativ- und Sterbebegleitung oder der Schmerztherapie. URN: urn:nbn:de:101:1-2022102511002581902415DOI: 10.5281/zenodo.7118469Its possible to study pain, chronic illness and death from different angles, apart from the biomedical approach, or the perspectives and models of psychology, the palliative and terminal care view, and even more so, to the branch of medicine that scientifically studies pain and its treatment, algology.Podemos estudiar el dolor, las enfermedades cr√≥nicas y la muerte desde √°ngulos distintos al modelo biom√©dico, a las perspectivas y modelos de la psicolog√≠a, a los cuidados paliativos y los cuidados terminales, y m√°s a√ļn, a la rama de la medicina que estudia de forma cient√≠fica el dolor y su tratamiento, la algolog√≠a. URN:¬†urn:nbn:de:101:1-2022102510580188119520DOI:¬†10.5281/zenodo.711845

    Apuntes Iniciales Sobre Epistemología Yulu

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    Initial notes on epistemology Yulu (epistemologies from the heart), alluding to the center of the American region, is a thesis about the production of knowledge from Central America and the Caribbean. Above all, it refers to knowledge that respects and makes ancestral wisdom visible, from a Nahuat nosological triangle. The punctual distinction of this text consists of providing basic and initial principles about the generation of knowledge from the first nations - native people of Central America and the Caribbean- in a constant dialogue between disciplines. It is proposed as a method to counteract epistemicide, and as an example it shows how Castilian-centrism and simple-linear translations make ancestral knowledge invisible. It reviews the root and syntax of ‚ÄúYul‚ÄĚ in different sources and also raises the split between sciences and the absence of a heterogeneous perspective to address phenomena, such as the case of linguistics and anatomy. The article describes two main columns of Yulu epistemology: creativity and pedagogy. Both spheres articulated in a methodological precision and a heterogeneous perspective of the phenomena. The work reviews the intercultural competences of UNESCO, and is a first approximation about the being and doing of people who seek to be part of Yulu epistemology, whose main goal is to promote dignity of the native people of Central America and the Caribbean. From the rescue and visibility of their ancestral knowledge, in harmony with their identity.Apuntes iniciales sobre epistemolog√≠a Yulu (epistemolog√≠as del coraz√≥n), en alusi√≥n al centro de la regi√≥n de Am√©rica, es una tesis acerca de la producci√≥n de conocimiento desde Centroam√©rica y el Caribe. Sobre todo, refiere el conocimiento que respete y visibilice la sabidur√≠a ancestral, desde un tri√°ngulo nosol√≥gico del n√°huat. La distinci√≥n puntual de este texto consiste en aportar principios b√°sicos e iniciales acerca de la generaci√≥n de conocimiento desde los pueblos originarios de Centroam√©rica y el Caribe, en un di√°logo constante entre disciplinas. Se plantea como un m√©todo para contrarrestar el epistemicidio y, en ejemplo, muestra c√≥mo el castellano-centrismo y las traducciones simples y lineales invisibilizan el conocimiento ancestral. Revisa la ra√≠z y la sintaxis de Yul en diferentes fuentes y tambi√©n plantea la escisi√≥n entre las ciencias y la ausencia de una perspectiva heterog√©nea para abordar los fen√≥menos, como el caso de la ling√ľ√≠stica y la anatom√≠a. El art√≠culo describe las dos columnas principales de la epistemolog√≠a Yulu: la creatividad y la pedagog√≠a. Ambas esferas se articulan en un rigor metodol√≥gico y una perspectiva heterog√©nea de los fen√≥menos. El trabajo revisa las competencias interculturales de la UNESCO, al ofrecer una primera aproximaci√≥n acerca del ser y quehacer de las personas que buscan formar parte de la epistemolog√≠a Yulu. Su meta principal es promover la dignidad de los pueblos originarios de Centroam√©rica y El Caribe a partir del rescate y visibilizaci√≥n de su saber ancestral, en armon√≠a con su identidad

    Estigma y Discriminacion Relacionado con el Abuso de Sustancias

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    Over the past few decades, international research has documented that stigma and discrimination is one of the major barriers to care in the field of drug abuse worldwide. Objective: To show the findings of the international literature about specific populations that experience stigma or discrimination as one of the main barriers to care in substance abuse as well as to account for the development of public policies against stigma in mental health and addictions in consonance with goals 3, 10 and 16 of the Sustainable Development Goals.En las √ļltimas d√©cadas, se ha documentado en la investigaci√≥n a nivel internacional, que el estigma y la discriminaci√≥n constituyen una de las principales barreras para la atenci√≥n en el √°mbito del abuso de drogas en todo el mundo. Objetivo: Mostrar los hallazgos de la literatura internacional acerca de poblaciones espec√≠ficas que experimentan estigma o discriminaci√≥n como una de las principales barreras para la atenci√≥n en el abuso de sustancias as√≠ como dar cuenta del desarrollo de pol√≠ticas p√ļblicas anti estigma en salud mental y adicciones en consonancia con los objetivos 3, 10 y 16 de los Objetivos de Desarrollo Sostenible

    Development and evaluation of a nanofiber membrane in vitro as a therapeutic alternative for the post treatment in breast cancer cell in a murine model

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    Worldwide female breast cancer is the most commonly diagnosed cancer, with an estimated 2.3 million new cases in 2020, reason for the need of targeted therapies that can maximize treatment success and minimize toxicity. Nanoparticles of gold (AuNps) exhibit cytotoxic properties against certain types of cancer cell lines. Nanofibers have been use in the drug delivery systems due to its degradability and high surface area. We proposed a membrane with nanometric fibers using polivinilic alcohol (PVA) and chitosan (Qts) loaded with AuNps and Doxorubicin (Doxo) with the purpose of diminish tumor regression. PVA-Qts membrane was develop with electrospinning, the injection, voltage, distance and relative humidity parameters were standardized and it were characterized by Microscopic Atomic Force. The cytotoxicity with a median lethal dose (DL50) in two cell lines, breast adenocarcinoma murine (4T1) and murine fibroblast (NiH3T3) as a healthy control were evaluated. AuNps had a size of 3 nanometers (nm) with a Z potential of 13.2 mVolts and a DL50 of 75 ¬ĶM in the cell line 4T1. Doxo was decrease in 95% with a final concentration of 0.03 mg/cm2. Both doses were loaded in the PVA-Qts solution. PVA-Qts-Doxo and PVA-Qts-AuNps-Doxo decrease the viability in 4T1 in 24 hours with a 15%, 72 hours with a 28%, the first with 60% and the latter with 82%. PVA-Qts-Doxo and PVA-Qts-AuNps-Doxo in NiH3T3 diminish incrementing with the time reaching a 40% in 120 hours. Finally, The viability for 4T1 cultured on PVA-Qts-Doxo was minor than in NiH3T3. The amount of Doxo in the membrane synthetized was 95% less than the employ doses, demonstrating that the fiber improves the delivery of the chemotherapeutic in a palatine time

    Effect of Arbuscular Mycorrhizal Colonization on Cadmium‚ÄźMediated Oxidative Stress in Glycine max (L.) Merr.

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    Cadmium is a heavy metal (HM) that inhibits plant growth and leads to death, causing great losses in yields, especially in Cd hyperaccumulator crops such as Glycine max (L.) Merr. (soybean), a worldwide economically important legume. Furthermore, Cd incorporation into the food chain is a health hazard. Oxidative stress (OS) is a plant response to abiotic and biotic stresses with an intracellular burst of reactive oxygen species (ROS) that causes damage to lipids, proteins, and DNA. The arbuscular mycorrhizal fungal (AMF) association is a plant strategy to cope with HM and to alleviate OS. Our aim was to evaluate the mitigation effects of mycorrhization with AMF Rhizophagus intraradices on soybean growth, nutrients, Cd accumulation, lipid peroxidation, and the activity of different antioxidant agents under Cd (0.7‚Äď1.2 mg kg‚ąí1 bioavailable Cd) induced OS. Our results suggest that glutathione may act as a signal molecule in a defense response to Cd-induced OS, and mycorrhization may avoid Cd-induced growth inhibition and reduce Cd accumulation in roots. It is discussed that R. intraradices mycorrhization would act as a signal, promoting the generation of a soybean cross tolerance response to Cd pollution, therefore evidencing the potential of this AMF association for bioremediation and encouragement of crop development, particularly because it is an interaction between a worldwide cultivated Cd hyperaccumulator plant and an AMF‚ÄďHM‚Äďaccumulator commonly present in soils.Fil: Molina, Alicia Susana. Universidad Nacional de San Luis; ArgentinaFil: Lugo, M√≥nica Alejandra. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro Cient√≠fico Tecnol√≥gico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biol√≥gicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias F√≠sico Matem√°ticas y Naturales. Instituto Multidisciplinario de Investigaciones Biol√≥gicas de San Luis; ArgentinaFil: P√©rez Chaca, Mar√≠a V.. Universidad Nacional de San Luis; ArgentinaFil: Vargas Gil, Silvina. Instituto Nacional de Tecnolog√≠a Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patolog√≠a Vegetal; Argentina. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas; ArgentinaFil: Zirulnik, Fanny. Universidad Nacional de San Luis; ArgentinaFil: Leporati, Jorge Leandro. Universidad Nacional de San Luis; ArgentinaFil: Ferrol, Nuria. Consejo Superior de Investigaciones Cient√≠ficas. Estaci√≥n Experimental del Zaid√≠n; Espa√ĪaFil: Azc√≥n Gonz√°lez de Aguilar, Concepci√≥n. Consejo Superior de Investigaciones Cient√≠ficas. Estaci√≥n Experimental del Zaid√≠n; Espa√Ī

    DAMIC at SNOLAB

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    We introduce the fully-depleted charge-coupled device (CCD) as a particle detector. We demonstrate its low energy threshold operation, capable of detecting ionizing energy depositions in a single pixel down to 50 eVee. We present results of energy calibrations from 0.3 keVee to 60 keVee, showing that the CCD is a fully active detector with uniform energy response throughout the silicon target, good resolution (Fano ~0.16), and remarkable linear response to electron energy depositions. We show the capability of the CCD to localize the depth of particle interactions within the silicon target. We discuss the mode of operation and unique imaging capabilities of the CCD, and how they may be exploited to characterize and suppress backgrounds. We present the first results from the deployment of 250 um thick CCDs in SNOLAB, a prototype for the upcoming DAMIC100. DAMIC100 will have a target mass of 0.1 kg and should be able to directly test the CDMS-Si signal within a year of operation.Comment: 13 pages, 12 figures, proceedings prepared for 13th International Conference on Topics in Astroparticle and Underground Physics (TAUP2013

    Left ventricular Myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis.

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    Background: Diagnostic Task Force Criteria (TFC) for arrhythmogenic cardiomyopathy (AC) exhibit poor performance for left dominant forms. TFC only include right ventricular (RV) dysfunction (akinesia, dyssynchrony, volumes and ejection fraction). Moreover, cardiac magnetic resonance imaging (CMRI) assessment of left ventricular (LV) dyssynchrony has hitherto not been described. Thus, we aimed to comprehensively characterize LV CMRI behavior in AC patients. Methods: Thirty-five AC patients with LV involvement and twenty-three non-affected family members (controls) were enrolled. Feature-tracking analysis was applied to cine CMRI to assess LV ejection fraction (LVEF), LV endsystolic and end-diastolic volume indexes, strain values and dyssynchrony. Regions with more frequent strain and dyssynchrony impairment were also studied. Results: Radial dyssynchrony and LVEF were selected (sensitivities 54.3% and 48.6%, respectively at 100% specificity), with a threshold of 70 ms for radial dyssynchrony and 48.5% for LVEF. 71.4% of patients exceeded these thresholds (31.4% both, 22.9% only dyssynchrony and 17.1% only LVEF). Considering these cut-off values as a novel combined criterion, 30% of patients with 'borderline' or 'possible' AC following 2010 TFC would move to a 'definite' AC diagnosis. Strain was globally impaired whereas dyssynchronous regions were more often apical and located at the inferolateral wall. Conclusions: Mirroring the RV evaluation, we suggest including LVEF and LV dyssynchrony to improve the diagnosis of AC. Two independent mechanisms can be claimed in AC patients with LV involvement: 1) decreased myocardial deformation with global LV affectation and 2) delayed myocardial contraction at localized regions

    Biología floral y polinización de Ipomoea murucoides Roem. & Schult. (Convolvulaceae) en Ixtapan del Oro, Estado de México (México)

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    En el presente estudio se describen algunas de las adaptacionesde las flores de Ipomoea murucoides con respecto a su interacci√≥ncon los visitantes florales as√≠ como el sistema de reproducci√≥n se-xual en una Selva Baja Caducifolia de M√©xico. La antesis crepus-cular, el patr√≥n en la producci√≥n de n√©ctar y la concentraci√≥n deaz√ļcares, el pedicelo robusto y el color y tama√Īo de las flores soncongruentes con el s√≠ndrome floral de la quiropterof√≠lia. No obs-tante, se observ√≥ que adem√°s del murci√©lago Anoura geoffroyi, lasflores de I. murucoides tambi√©n las visitaron durante el d√≠a colibr√≠-es (Colibri thalassinus, Eugenes fulgens y Heliomaster constantii),abejas carpinteras (Xylocopa guatemalensis y X. tenuata) y esca-rabajos (Cerambycidae). Los murci√©lagos, al ser los primeros visi-tantes de las flores, resultaron ser los polinizadores m√°s importan-tes de I. murucoides, una especie al√≥gama y, al parecer, autoin-compatible

    Effect of pelagic Sargassum on in vitro dry matter and organic matter degradation, gas production, and protozoa population

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    This study determined the effect of pelagic Sargassum on in vitro dry matter and organic matter degradation, total gas production (TGP), and protozoa population. The treatments were different levels of Sargassum inclusion on a basal substrate (Stargrass hay; Cynodon nlemfuensis) as follows: T0 (control treatment based on Stargrass hay), T10 (90% Stargrass hay + 10% Sargassum), T20 (80% Stargrass hay + 20% Sargassum), and T30 (70% Stargrass hay + 30% Sargassum). Ruminal fermentation kinetics and protozoa population were determined during 72 h of in vitro incubations. Compared to control, dry matter degradability at 48 and 72 h and organic matter degradability at 24 and 48 h were higher in Sargassum treatments. TGP was lower with T20 at 48 h. The total population of protozoa and the concentration of Entodinium spp. were lower at T20 at 48 h and T30 at 72 h. Cl, S, Ca, K, and Zn (103, 5.97, 88.73, 285.70 g/kg, and 15,900 mg/kg) were high in Sargassum, reaching twice or even nine times higher than the contents in Stargrass (11.37, 1.60, 43.53, 87.73 g/kg, and 866.67 mg/kg). Overall, up to 30% pelagic Sargassum could be included in hay-based substrates from tropical grasses without negative effects on in vitro dry matter and organic matter degradability
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