402 research outputs found

    Anthracycline Cardiotoxicity

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    A 3-D micromechanical multi-loop magnetometer driven off-resonance by an on-chip resonator

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    This paper presents the principle and complete characterization of a single-chip unit formed by microelectromechanical system magnetometers to sense the 3-D magnetic field vector and a Tang resonator. The three sensors, nominally with the same resonance frequency, are operated 200-Hz off-resonance through an ac current whose reference frequency is provided by the resonator embedded in an oscillating circuit. The sensors gain is increased by adopting a current recirculation strategy using metal strips directly deposited on the structural polysilicon. At a driving value of 100 μArms flowing in series through the three devices, the magnetometers show a sub-185 nT/Hz Hz resolution with a selectable bandwidth up to 50 Hz. Over a ±5-mT full-scale range, the sensitivity curves show linearity errors lower than 0.2%, with high cross-axis rejection and immunity to external accelerations. Under temperature changes, the stability of the 200-Hz difference between the magnetometers and the resonator frequency is within 55 ppm/K. Offset is trimmed down to the microtesla range, with an overall measured Allan stability of about 100 nT at 20-s observation time. [2016-0030

    Posaconazole and midostaurin in patients with FLT3-mutated acute myeloid leukemia: Pharmacokinetic interactions and clinical facts in a real life study

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    : Midostaurin is used in combination with chemotherapy to treat patients with newly diagnosed FLT3-mutated acute myeloid leukemia. Chemotherapy-induced neutropenia exposes these patients to a significant risk of invasive fungal infections (IFIs). International guidelines recommend primary antifungal prophylaxis with posaconazole (PCZ) but nested analysis of a phase III trial showed that strong PCZ inhibition of CYP3A4 diminished midostaurin metabolism and increased midostaurin plasma levels; however, midostaurin-related adverse events (AEs) were only moderately exacerbated. We conducted a prospective multicenter real-life study to evaluate (i) how often concerns around PCZ-midostaurin interactions made the hematologist prescribe antifungals other than PCZ, (ii) how remarkably PCZ increased midostaurin plasma levels, and (iii) how significantly PCZ-midostaurin interactions influenced hematologic and safety outcomes of induction therapy. Although the hematologists were blinded to pharmacokinetic findings, as many as 16 of 35 evaluable patients were prescribed antifungal prophylaxis with micafungin, weak CYP3A4 inhibitor, in place of PCZ (p < 0.001 for deviation from guidelines). In the 19 patients managed as per guidelines, PCZ-midostaurin interactions were more remarkable than previously characterized, such that at the end of induction therapy midostaurin minimum plasma concentration (Cmin ) was greater than three times higher than reported; moreover, midostaurin Cmin , maximum plasma concentration, and area under the curve were more than or equal to four times higher with PCZ than micafungin. Hematologic outcomes (complete remission and duration of severe neutropenia) and safety outcomes (midostaurin-related any grade or grade ≥3 AEs) were nonetheless similar for patients exposed to PCZ or micafungin, as was the number of breakthrough IFIs. In waiting for randomized phase III trials of new prophylaxis regimens, these findings show that PCZ should remain the antifungal of choice for the midostaurin-treated patient

    Chasing the light sterile neutrino: status of the STEREO experiment

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    International audienceThis article describes the status of the STEREO experiment. STEREO is a short-baseline reactor antineutrino experiment, whose primary goal is to study oscillations involving extra sterile neutrino states with Δm 2 ∼ 0.1 − 1 eV, an hypothesis suggested by existing anomalies. Such hypothesis is tested by comparing antineutrino spectra in 6 identical cells located at a increasing distance from the reactor core of the ILL facility. Calibration sources have been used to characterise the detector response, perform energy reconstruction, and study the detection efficiency. Results of these studies, along with preliminary antineutrino and background rates, are reported here. STEREO has started operating in November 2016 and will collect data for 8 reactor cycles. Preliminary results based on 1.5 reactor cycles and ongoing analysis, which are mentioned here, will be released in early 2018

    Exploitation de l'analyse des formes d'impulsion pour la réjection du background correlée et l'identification de l'ortho-positronium dans l'expérience Double Chooz

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    The measurement of the theta-13 mixing angle, to which the Double Chooz experiment contributed, paves the way to future findings in neutrino physics. In this manuscript, we describe the characterization of some Double Chooz backgrounds. Cosmic muons that stop and decay in the detector are characterized by anisotropic emission of the scintillation light, causing the vertex to be poorly reconstructed. The resulting pulse shape distortion can be used to tag and remove such background. Fast spallation neutrons producing multiple recoil protons may produce a similar distortion in the pulse shape and can also be tagged. Pulse shapes are also used to identify the formation of ortho-positronium. The tagging of such electron-positron bound state is made possible by the induced distortion in the pulse shape due to the delay in the positron annihilation, and can be used for an electron-positron separation.La mesure récente de l'angle de mélange theta-13, à laquelle l'expérience Double Chooz contribue, a ouvert la voie aux futures expériences de la physique des neutrinos. Dans ce manuscrit, la caractérisation de certains bruits de l'expérience sont décrits. Les muons cosmiques qui s'arrêtent et se désintègrent dans le détecteur sont mal reconstruits, résultant en distorsion de la distribution temporelle des signaux laquelle peut être utilisée pour identifier ce type de fond. Les neutrons rapides créés par spallation par les muons cosmiques produisent de nombreux protons de recul qui peuvent entraîner un décalage dans la distribution temporelle des signaux et ainsi être identifiés. Ces distributions temporelles ont aussi été utilisées pour identifier la formation de l'état d'orthopositronium en observant et en mesurant un délai entre l'ionisation du positron et l'annihilation de celui-ci, pouvant permettre une séparation positron-électron

    Status of the Supernemo Experiment

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    International audienceThe SuperNEMO Demonstrator is undergoing its final integration and commissioning phase. It builds on the success of the NEMO-3 tracking-calorimetry technique, and aims to improve the sensitivity on the 0νββ (T1/2 > 6 × 1024 y with 6.3 kg of 82Se) thanks to a better background mitigation and event detection. Its scientific scope includes detailed studies of the 2νββ, single-state vs higher-state dominance discrimination, and the constraining of gA. The Demonstrator acts as a proof of principle of a full scale 100 kg multi-module detector, the sensitivity of which will scratch into the inverted hierarchy region

    Neutrino oscillation from reactor experiments, the reactor anomaly, and light sterile neutrinos

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    From the discovery of the neutrino to the measure of the last of the neutrino mixing parameters, nuclear reactors have proved indispensable in the study of these particles, of which much remains to be unveiled. Recent and past measurements using reactor neutrinos rely on the prediction of their spectrum, a non-trivial exercise involving ad- hoc methods and carefully-selected assumptions. A discrepancy between predicted and measured fluxes at very short baselines, known as reactor antineutrino anomaly, arose in 2011, prompting a considerable scientific production as well as the birth of new experiments aiming to study neutrino oscillation at very short baseline. Such anomaly can be in fact explained invoking the existence of a new sterile neutrino at the eV mass scale participating in the neutrino mixing, an enticing hypothesis that ties to other anomalies already observed in the neutrino sector and opens a door for physics beyond the Standard Model. The speaker will present an overview on the past and present studies of neutrino oscillation using reactor neutrinos, with a focus on recent results on sterile neutrino searches at short baseline, as well as a reference to the future flagship projects of this domain. </div

    Prospects of the Upgrade-II of LHCb

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    Observation of ortho-positronium formation in Double Chooz

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    International audienceThe aim of the Double Chooz experiment is to measure the neutrino mixing angle θ13 by detecting the reactor electron anti-neutrino via inverse beta decay. The positron-neutron delayed coincidence yields a sizeable background suppression; a further contribution might come from the development of techniques for an efficient identification of positrons. Pulse shape discrimination, a well-established technique for background rejection in liquid scintillator detectors, fails in separating positrons from electrons, as they give rise to identical light pulses. However, in some cases the positron decay is delayed by the formation of a positron-electron metastable bound state, called ortho-positronium (o-Ps), which introduces a delay between the light signal from the positron energy deposition in the scintillator and the one from the annihilation gammas. The consequent deformation in the positron-induced light pulse can be exploited to identify positrons with the pulse shape discrimination, as already successfully done statistically in Borexino.In Double Chooz, we performed the first o-Ps formation tagging on an event-by-event basis. We also measured the o-Ps formation probability and its lifetime, finding (44 ± 13)% and (3.68 ± 0.23) ns respectively. These values are in good agreement with independent measurements obtained with a dedicated setup
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