5 research outputs found

    1-ALKYL-3-METHYLIMIDAZOLIUM TETRAFLUOROBORATE AS AN ALTERNATIVE MOBILE PHASE ADDITIVES FOR DETERMINATION OF HALOPERIDOL IN PHARMACEUTICAL FORMULATION BY HPTLC UV DENSITOMETRIC METHOD

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    An alternative thin-layer chromatography (TLC) method for the determination of haloperidol in pharmaceutical formulation against the method proposed by European Pharmacopeia (7.0) has been compared and described. The proposed method uses a mobile phase composed of acetonitrile/ water, 60:40, with the addition of 1.5% (v/v) 1-ethyl-3-methylimidazolium tetrafluoroborate ionic liquid. The ionic liquid modifiers of a mobile phase have been shown to be suitable suppressor of silanol ionization in the TLC of basic drugs. Besides the silanol-suppressing potency of the 1-ethyl-3-methylimidazolium tetrafluoroborate, the lack of interaction and interference with UV densitometric detection was observed. These properties open a new possibilities in the application of alky-imidazolium-based ionic liquids in chromatographic techniques

    Influence of the Anionic Part of 1-Alkyl-3-Methylimidazolium-Based Ionic Liquids on the Chromatographic Behavior of Perazine in RP-HPTLC

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    1-Alkyl-3-methylimidazolium-based ionic liquids (tetrafluoroborate, L-(ţ)-lactate and ethyl sulfate) were used as mobile phase additives to assess the effect of its anionic part on the retention mechanism of perazine in pharmaceutical formulation in reversed-phase highperformance thin-layer chromatography (RP-HPTLC) method. In all cases, significant changes and improvements in the retention factor were observed when ionic liquids were added to the mobile phase. We found that the chromatographic behavior of the basic analyte depends on the utilized ionic liquid as well as its various anions. Enhancement of separation confirms silanol suppressing potency of employed ionic liquids and their positive impact on chromatographic separation of basic drugs. Among selected ionic liquids, the optimum distribution parameters such as shape and quality of spots, high precision, and accuracy in qualitative and quantitative determination characterize the system with [EMIm][BF4] as mobile phase modifier. Our proposed HPTLC method for determination of perazine in oral tablets was also subjected to subsequent validation procedure in accordance with ICH guidelines and proved to be suitable, inexpensive, and convenient method in a pharmaceutical analysi

    Application of geoelectrical profiling in the delineation of shallow periglacial structureson the Drohiczyn Plateau

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    The pa per de scribes the re sults of geoelectrical sound ing ap pli ca tion for the de lin ea tion of periglacial struc tures in Wierzchuca Nag├│rna within the Drohiczyn Pla teau (east ern Po land). The method re cords the vari a tion of ap par ent re - sis tiv ity of de pos its along a se lected hor i zon tal di rec tion. The sur vey uti lizes a dis tinct geoelectrical con trast be tween gla cial till and struc tures com posed of sand that have been rec og nized ear lier in the gravel pit wall. The stud ies have been con ducted in di rect hin ter land of the gravel pit. Rect an gu lar and con cen tric ar rays were ap plied in the sur vey. The re sults have been pre sented as graphs and re sis tance dis tri bu tion maps. The ob tained geo log i cal im age is not complete, al though it shows an ori ented course of the larg est lin ea ments and traces of a net work with a small mesh size (1.5ÔÇô2 m). The rec og nized pat tern of struc tures points to harsh cli ma tic con di tions dur ing their for ma tion. Gen eral ori - en ta tion of the struc tures cor re sponds to the ba sic el e ments of the con tem po rary land scape in the area (slope, val ley axes). Geoelectrical sound ing us ing the rect an gu lar ar ray gave better re sults than in the con cen tric ar ray, whereas in - tro duc tion of brine into the sys tem did not en hance the res o lu tion of the read ings. The pre sented re sis tance dis tri bu tion maps with a char ac ter is tic rhythm of vari a tions may serve as a bench mark for rec og niz ing periglacial struc tures in areas with out ex po sures

    Ionic Liquids as Mobile Phase Additives for Feasible Assay of Naphazoline in Pharmaceutical Formulation by HPTLCÔÇôUVÔÇôDensitometric Method

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    A specific and reliable High-Performance Thin Layer Chromatography (HPTLC) with densitometry detection method has been developed for determination of naphazoline nitrate in nasal drops. The best separation of basic analyte, without spot tailing, was achieved using the mobile phase composed of acetonitrile:water (60:40,v/v) with 1.5 % (v/v) imidazolium-class ionic liquid added and the plates covered with stationary phase based on the RP-18 with F254S (10cm x 20cm). The presented results confirm that imidazolium tetrafluoroborate ionic liquids are efficient suppressors of free silanols, which are considered to be responsible for troublesome and irreproducible chromatographic determinations of basic compounds. The developed chromatographic system was found to be convenient in use and at the same time providing a repeatable assay of naphazoline nitrate in nasal drops, which could not be obtained with the use of standard silanol suppressing mobile phase additives, like triethylamine (TEA) or dimethyloctylamine (DMOA)
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