12 research outputs found

    Characteristics of the total study population.

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    <p>The data are expressed as the mean ± standard deviation as well as the median (IQR) and counts (%).</p><p>* p-value based on the Wilcoxon rank sum test.</p><p>Characteristics of the total study population.</p

    Increasing Live Birth Rate by Preimplantation Genetic Screening of Pooled Polar Bodies Using Array Comparative Genomic Hybridization - Fig 2

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    <p>(A) Number of chromosomal aberrations in aneuploid oocytes. In total, the polar bodies of 530 oocytes were tested by aCGH, and 359 were found to have a chromosomal aberration. Approximately 65% of aneuploid oocytes had two or more aneuploidies. (B) Distribution of chromosome errors in aneuploid oocytes. All chromosomes were found to be involved in aneuploidies. Aneuploidy of chromosome 4 was observed in only 10% of oocytes, while chromosome 19 aberrations were most frequently detected in up to 30% of oocytes.</p

    Table_1_The impact of regional origin on the incidence of gestational diabetes mellitus in a multiethnic European cohort.docx

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    IntroductionWomen with migration background present specific challenges related to risk stratification and care of gestational diabetes mellitus (GDM). Therefore, this study aims to investigate the role of ethnic origin on the risk of developing GDM in a multiethnic European cohort.MethodsPregnant women were included at a median gestational age of 12.9 weeks and assigned to the geographical regions of origin: Caucasian Europe (n = 731), Middle East and North Africa countries (MENA, n = 195), Asia (n = 127) and Sub-Saharan Africa (SSA, n = 48). At the time of recruitment maternal characteristics, glucometabolic parameters and dietary habits were assessed. An oral glucose tolerance test was performed in mid-gestation for GDM diagnosis.ResultsMothers with Caucasian ancestry were older and had higher blood pressure and an adverse lipoprotein profile as compared to non-Caucasian mothers, whereas non-Caucasian women (especially those from MENA countries) had a higher BMI and were more insulin resistant. Moreover, we found distinct dietary habits. Non-Caucasian mothers, especially those from MENA and Asian countries, had increased incidence of GDM as compared to the Caucasian population (OR 1.87, 95%CI 1.40 to 2.52, p DiscussionPrevalence of GDM was higher among women from MENA and Asian countries, who already showed adverse glucometabolic profiles at early gestation. Fasting glucose and early gestational insulin resistance (as well as higher BMI in women from Asia) were identified as important risk factors in Caucasian and non-Caucasian patients.</p

    To Assess the Association between Glucose Metabolism and Ectopic Lipid Content in Different Clinical Classifications of PCOS - Fig 3

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    <p>Bee swarm plot of ectopic lipids in different subgroups: controls (CONT), females with PCOS classified by NIH 1999 criteria (PCOS-NIH) as well as females with PCOS additionally classified by the Rotterdam 2003 criteria (PCOS-ROT): A: Hepatocellular lipids (HCL), B: intramyocellular lipids (IMCL) in soleus muscle, C: intramyocellular lipids (IMCL) in tibialis muscle. Lines indicate first, second (median) and third quartiles.</p