1,203 research outputs found

    Book review: Conducting for a new era, by Edwin Roxburgh

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    Book review of: Conducting for a new era, by Edwin Roxburgh.Publisher PD

    On-chip generation of heralded photon-number states

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    Beyond the use of genuine monolithic integrated optical platforms, we report here a hybrid strategy enabling on-chip generation of configurable heralded two-photon states. More specifically, we combine two different fabrication techniques, \textit{i.e.}, non-linear waveguides on lithium niobate for efficient photon-pair generation and femtosecond-laser-direct-written waveguides on glass for photon manipulation. Through real-time device manipulation capabilities, a variety of path-coded heralded two-photon states can be produced, ranging from product to entangled states. Those states are engineered with high levels of purity, assessed by fidelities of 99.5±\pm8\% and 95.0±\pm8\%, respectively, obtained via quantum interferometric measurements. Our strategy therefore stands as a milestone for further exploiting entanglement-based protocols, relying on engineered quantum states, and enabled by scalable and compatible photonic circuits

    Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity.

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    Glycogen and lipids are major storage forms of energy that are tightly regulated by hormones and metabolic signals. We demonstrate that feeding mice a high-fat diet (HFD) increases hepatic glycogen due to increased expression of the glycogenic scaffolding protein PTG/R5. PTG promoter activity was increased and glycogen levels were augmented in mice and cells after activation of the mechanistic target of rapamycin complex 1 (mTORC1) and its downstream target SREBP1. Deletion of the PTG gene in mice prevented HFD-induced hepatic glycogen accumulation. Of note, PTG deletion also blocked hepatic steatosis in HFD-fed mice and reduced the expression of numerous lipogenic genes. Additionally, PTG deletion reduced fasting glucose and insulin levels in obese mice while improving insulin sensitivity, a result of reduced hepatic glucose output. This metabolic crosstalk was due to decreased mTORC1 and SREBP activity in PTG knockout mice or knockdown cells, suggesting a positive feedback loop in which once accumulated, glycogen stimulates the mTORC1/SREBP1 pathway to shift energy storage to lipogenesis. Together, these data reveal a previously unappreciated broad role for glycogen in the control of energy homeostasis

    A Catalog and Atlas of Cataclysmic Variables: The Final Edition

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    The Catalog and Atlas of Cataclysmic Variables has been a staple of the CV community for over 10 years. The catalog has grown from 751 CVs in 1993 to 1600 CVs at present. The catalog became a ``living'' edition in 2001, and its contents have been continually updated since that time. Effective 27 January 2006, the catalog will transition to an archival site, with no further updates to its contents. While it is antipicated that the site will remain active, we present the complete contents of the site as a precaution against a loss of the on-line data.Comment: 8 pages, including 6 table
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