292 research outputs found

    A REVIEW ON THE VARIOUS BIOLOGICAL ACTIVITIES OF THIADIAZOLE

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    Thiadiazole and their derivatives have been studied colossally because of their wide range of biological activity. They are found to be effectual as antibacterial, antimalarial, antiviral, antiinflammatory, anticancer and antianthelminthic agents. Distinct biological activities, such as antibacterial, anti-inflammatory, and antiviral have been consort with 1, 3, 4-thiadiazole derivatives. The substituted 1, 3, 4 Thiadiazole nucleus is particularly ubiquitous, and found in some marketed drugs such as acetazolamide, Methazolamide and antibacterial such as Sulphamethazole, antibiotic like Cefazoline. The synthesis of 1, 3, 4 Thiadiazole derivatives has allured widespread attention due to their diverse biological activities, including antimicrobial, anti-inflammatory, analgesic, and antianthelmintic. These reviews focused on various biological activities consorted with thiadiazole nucleus.Â

    Prevalence of hepatitis B and C among patients admitted in respiratory medicine ward of a tertiary care hospital in Mullana, Ambala, Haryana, India

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    Background: Viral Hepatitis B and C have become a major public health problem. Hepatitis B affects approximately 30% of world population or about 2 billion people have serological evidence of either current or past infection. Hepatitis C virus infects approximately 3% of world population placing about 170 million people at risk of liver disease. In India, HBsAg prevalence rates among general population ranges from 0.1% to 11.7%, being 2% to 8% in most studies and seroprevalence for Hepatitis C ranges from 0.1% to 8% among general population.Methods: The study was conducted in the respiratory medicine Ward, MMIMSR in the month of August 2016. 200 patients were taken up for the study after clinical examination, necessary investigation and proper consent. Patients were tested for HBsAg antigen and HCV Tridot. Patients were put through a carefully designed questionnaire to look for possible cause of infection. Patients who came out to be positive for either Hepatitis B or C were counselled about further investigations and treatment options.Results: The prevalence rate for Hepatitis B came out to be 9% and for Hepatitis C was 5.5%. Hepatitis has become a major public health issue in India particularly in the rural areas. High prevalence rates among patients with respiratory diseases can be attributed to unsafe therapeutic injections and use of shared needles.Conclusions: There is a need to carry out larger studies to better elucidate the epidemiology of Hepatitis B and C and to identify high prevalence areas and simultaneously focus on improving public health measures to prevent disease transmission and decrease the burden of disease

    SYNTHESIS OF SOME NOVEL TRIAZOLE DERIVATIVES AS SCHIFF BASES AND THEIR ANTIMICROBIAL EVALUATION

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    Objective: This work involves the synthesis of some novel schiff base derivatives synthesized from p-amino benzoic acid.Methods: A series of 4-[4-(arylidene amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl]-benzoic acid complexes were synthesized from 4-(4-amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl)-benzoic acid by reaction with different aromatic aldehydes. All the synthesized schiff base derivatives were characterized by using analytical techniques (FT-IR, 1H NMR and Mass spectroscopy). The title compounds were evaluated for antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Streptococcus pneumoniae) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and anti-fungal activity against (Candida albicans and Aspergillus niger).Results: Schiff base derivatives 5(a-h) were synthesized in good yields and showed antimicrobial activity, among them, compounds 5c, 5d, 5e and 5f were significantly active against gram positive, gram negative bacterial and fungal strains and rest of compounds showed moderate to weak activity.Conclusion: The Schiff base obtained showed variation in the antimicrobial and antifungal activity, based on the structure of the substituted aromatic aldehydes

    Role of nutritional supplements in the management of tendinopathies: focus on combination of type 1 collagen, vitamin C and mucopolysaccharides

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    Tendinopathy is a common disease that is difficult to manage due to its recurrent nature. It is associated with increased healthcare costs and significantly impacts quality of life of patients. Also, according to recent studies patients with high cholesterol and diabetes are at a higher risk of developing tendinopathy. There has been rise in the incidence of tendinopathies due to increase in sport activities, life expectancy and some other factors (environment, diet and some drug therapies). Approximately 30% of visits for musculoskeletal pain in general practice are related to tendon injury. Non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids remain the mainstay of treatment. Despite the use of current therapies, there is need of a supportive therapy that can help in the healing process towards development of physiologically normal tendons. Nutraceuticals have been used as supportive therapy for management of tendinopathies. This review focuses on the management of tendinopathy with special attention on role of nutraceuticals such as type I collagen, mucopolysaccharides and vitamin C in the management of tendinopathy. Clinical data suggests that this combination (type I collagen, mucopolysaccharides and vitamin C) promotes the endogenous synthesis of collagen type I, avoiding the accumulation of collagen type III and aggrecan, thus interfering with the degeneration of tendon tissue. Based on the available clinical data, combination of type I collagen, mucopolysaccharides and vitamin C not only reduce the clinical symptoms but also improve structural evolution of different types of tendinopathies as well as plantar fascitis

    Removal of a Three Piece Foreign Body from a Child's Lung

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    Foreign body aspiration can be a life-threatening event especially in young children because they have smaller diameters of airway lumen, moreover, the delay in the diagnosis and subsequent therapeutic intervention can further increase the risk of morbidity. A retained foreign body can result in inflammatory response and granulation tissue formation around the object which make the foreign body removal difficult. In such situations surgical intervention is usually needed but with interventional pulmonology modalities we can restrict the need for surgery. Rigid bronchoscopy under general anaesthesia is the gold standard of diagnosis and management of foreign body aspiration. However, nowadays flexible bronchoscopy is more widely available and most pulmonary physicians are trained in its use so it can be used to remove such foreign bodies. We hereby report a case of a neglected foreign body which remained in the bronchus of a child for 11 days, successfully removed by flexible bronchoscopy

    Development of a novel HPTLC fingerprint method for simultaneous estimation of berberine and rutin in medicinal plants and their pharmaceutical preparations followed by its application in antioxidant assay

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    The present study was designed to develop and validate a high-performance thin-layer chromatography (HPTLC) system for the simultaneous quantitative determination of berberine and rutin in Tinospora cordifolia extract and their pharmaceutical preparations. Chromatographic development was done using a blend of n-hexane, ethyl acetate, glacial acetic acid and methanol (10:1.1:1.1:2.5, v/v) as the mobile phase. Detection was completed densitometrically at 254 nm. The RF estimation of berberine and rutin was observed to be 0.67 ± 0.02 and 0.47 ± 0.02, respectively. The developed HPTLC method was validated according to ICH guidelines; the method was specific, linear and accurate and can be used to determine berberine and rutin in marketed herbal preparations. The Tinospora cordifolia plant extract was further evaluated for antioxidant activity using HPTLC, and berberine was found to be more active than rutin during DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activity. The method was found simple, rapid, accurate, specific and robust for the analysis of berberine and rutin in crude drug using the same method

    Plants derived therapeutic strategies targeting chronic respiratory diseases: Chemical and immunological perspective

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    The apparent predicament of the representative chemotherapy for managing respiratory distress calls for an obligatory deliberation for identifying the pharmaceuticals that effectively counter the contemporary intricacies associated with target disease. Multiple, complex regulatory pathways manifest chronic pulmonary disorders, which require chemotherapeutics that produce composite inhibitory effect. The cost effective natural product based molecules hold a high fervor to meet the prospects posed by current respiratory-distress therapy by sparing the tedious drug design and development archetypes, present a robust standing for the possible replacement of the fading practice of poly-pharmacology, and ensure the subversion of a potential disease relapse. This study summarizes the experimental evidences on natural products moieties and their components that illustrates therapeutic efficacy on respiratory disorders
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