3,699 research outputs found

    Up in the Air: Lawson v. FMR LLC & the Scope of Sarbanes-Oxley Whistleblower Protection

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    This commentary previews an upcoming Supreme Court case, Lawson v. FMR LCC, in which the Court will consider whether Sarbanes-Oxley extends whistleblower protection to employees of the private contractors and subcontractors of public companies

    Household Characteristics of Higher Education Participants

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    The aim of this paper is to analyse the characteristics of Irish households that have a member participating in higher education, using surveys of Irish households collected in 1994-95 and 1999-2000. The results do not show a significant effect of income; this is notable, especially alongside the strong result that longer-term factors such as household wealth and cultural capital have a significant effect. This lends support to the argument proposed by Heckman (2000) that family income is only important over the entire educational investment cycle of a child. However, the importance of grant eligibility is a notable result, which suggests that short-term financial constraints cannot be dismissed. A combination of suitably beneficial short-term and long-term factors may be important for encouraging participation in higher education.higher education, human capital, credit constraints

    Information Markets as Games of Chance

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    Information Markets as Games of Chance

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    Grimm Trippin’: An Alternate Reality Game with Elements of Experimental Literature

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    Grimm Trippin’ is a work designed for print and digital mediums that is overlaid with game design elements seen in similar alternate reality games (ARGs) and interactive works, like S. or Building Stories. The goal of this project was to create a deconstructed, layered novel designed for new, explorative reading. It is a literary experiment that explores issues with the digitization of the novel and historical aspects of the ARG

    Marrying Universal Dependencies and Universal Morphology

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    The Universal Dependencies (UD) and Universal Morphology (UniMorph) projects each present schemata for annotating the morphosyntactic details of language. Each project also provides corpora of annotated text in many languages - UD at the token level and UniMorph at the type level. As each corpus is built by different annotators, language-specific decisions hinder the goal of universal schemata. With compatibility of tags, each project's annotations could be used to validate the other's. Additionally, the availability of both type- and token-level resources would be a boon to tasks such as parsing and homograph disambiguation. To ease this interoperability, we present a deterministic mapping from Universal Dependencies v2 features into the UniMorph schema. We validate our approach by lookup in the UniMorph corpora and find a macro-average of 64.13% recall. We also note incompatibilities due to paucity of data on either side. Finally, we present a critical evaluation of the foundations, strengths, and weaknesses of the two annotation projects.Comment: UDW1

    Acute Diagnosis of Wilson’s Disease in a Teenage Patient

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    Wilson’s Disease, a rare autosomal recessive genetic disease, is caused by a mutation in the ATP7B enzyme gene. Without this enzyme, copper builds up in the brain, liver, and cornea causing a multitude of symptoms. It is important to consider Wilson’s disease because the prognosis is dependent on timely diagnosis. This is an interesting case of a 19-year-old male who presented with suicidal thoughts and rapid weight loss. After many months and an extensive work-up, Wilson’s Disease was diagnosed. Due to his rapid decline, he was transferred to a larger university healthcare center where he is currently enrolled in clinical trial for WTX101

    Galaxy Formation In The Reionization Epoch As Hinted By Wide Field Camera 3 Observations Of The Hubble Ultra Deep Field

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    We present a large sample of candidate galaxies at z~7--10, selected in the HUDF using the new observations made by the HST/WFC3. Our sample is composed of 20 z-dropouts, 15 Y-dropouts, and 20 J-dropouts. The surface densities of the z-dropouts are close to what predicted by earlier studies, however, those of the Y- and J-dropouts are quite unexpected. While no Y- or J-dropouts have been found at AB < 28.0 mag, their surface densities seem to increase sharply at fainter levels. While some of these candidates seem to be close to foreground galaxies and thus could possibly be gravitationally lensed, the overall surface densities after excluding such cases are still much higher than what would be expected if the luminosity function does not evolve from z~7 to 10. Motivated by such steep increases, we tentatively propose a set of Schechter function parameters to describe the LFs at z~8 and 10. As compared to their counterpart at z~7, here L* decreases by ~ 6.5x and Phi* increases by 17--90x. Although such parameters are not yet demanded by the existing observations, they are allowed and seem to agree with the data better than other alternatives. If these LFs are still valid beyond our current detection limit, this would imply a sudden emergence of a large number of low-luminosity galaxies when looking back in time to z~10, which, while seemingly exotic, would naturally fit in the picture of the cosmic hydrogen reionization. These early galaxies could easily account for the ionizing photon budget required by the reionization, and they would imply that the global star formation rate density might start from a very high value at z~10, rapidly reach the minimum at z~7, and start to rise again towards z~6. In this scenario, the majority of the stellar mass that the universe assembled through the reionization epoch seems still undetected by current observations at z~6. [Abridged]Comment: accepted for publication in Research in Astronomy and Astrophysic

    Models of Care for High-Need, High-Cost Patients: An Evidence Synthesis

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    This brief analyzes experts' reviews of evidence about care models designed to improve outcomes and reduce costs for patients with complex needs. It finds that successful models have several common attributes: targeting patients likely to benefit from the intervention; comprehensively assessing patients' risks and needs; relying on evidence-based care planning and patient monitoring; promoting patient and family engagement in self-care; coordinating care and communication among patients and providers; facilitating transitions from the hospital and referrals to community resources; and providing appropriate care in accordance with patients' preferences. Overall, the evidence of impact is modest and few of these models have been widely adopted in practice because of barriers, such as a lack of supportive financial incentives under fee-for-service reimbursement arrangements. Overcoming these challenges will be essential to achieving a higher-performing health care system for this patient population

    The PAS domain-containing histidine kinase RpfS is a second sensor for the diffusible signal factor of <em>Xanthomonas campestris</em>

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    Summary: A cell-cell signalling system mediated by the fatty acid signal DSF controls the virulence of Xanthomonas campestris pv. campestris (Xcc) to plants. The synthesis and recognition of the DSF signal depends upon different Rpf proteins. DSF signal generation requires RpfF whereas signal perception and transduction depends upon the sensor RpfC and regulator RpfG. Detailed analyses of the regulatory roles of different Rpf proteins have suggested the occurrence of further sensors for DSF. Here we have used a mutagenesis approach coupled with high-resolution transcriptional analysis to identify XC_2579 (RpfS) as a second sensor for DSF in Xcc. RpfS is a complex sensor kinase predicted to have multiple Per/Arnt/Sim (PAS) domains, a histidine kinase domain and a C-terminal receiver (REC) domain. Isothermal calorimetry showed that DSF bound to the isolated N-terminal PAS domain with a Kd of 1.4μM. RpfS controlled expression of a sub-set of genes distinct from those controlled by RpfC to include genes involved in type IV secretion and chemotaxis. Mutation of XC_2579 was associated with a reduction in virulence of Xcc to Chinese Radish when assayed by leaf spraying but not by leaf inoculation, suggesting a role for RpfS-controlled factors in the epiphytic phase of the disease cycle.</p
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