341 research outputs found

    INQUIRE: a case study in evaluating the potential of online MCQ tests in a discursive subject

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    There has been a wealth of investigation into the use of online multiple-choice questions as a means of summative assessment, however the research into the use of formative MCQs by the same mode of delivery still remains patchy. Similarly, research and implementation has been largely concentrated within the Sciences and Medicine rather than the more discursive subjects within the Humanities and Social Sciences. The INQUIRE (Interactive Questions Reinforcing Education) Evaluation Project was jointly conducted by two groups at the University of Oxford-the Said Business School and the Academic Computing Development Team to evaluate the use of online MCQs as a mechanism to reinforce and extend student learning. This initial study used a small set of highly focused MCQ tests that were designed to complement an introductory series of first-year undergraduate management lectures. MCQ is a simple and well-established technology, and hence the emphasis was very much on situating the tests within the student experience. The paper will cover how the online MCQs are intended to fit into the Oxford Undergraduate study agenda, and how a simple evaluation was executed and planned to investigate their usage and impact. The chosen method of evaluation was to combine focus groups with automated online methods of tracking, and the paper discusses the findings of both of these

    Chasing Mr. C: Early Motion-Picture Exhibition in Robeson County, North Carolina (1896-1950)

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    This dissertation seeks to document the development of early moviegoing in a specific North Carolina county during the first half-century of commercial film exhibitions. Several local factors resulted in exhibition developments that often did not conform--or only partially conformed--to the metro-centric narratives that have dominated U.S. cinema history. Instead, Robeson's exhibitors and audiences faced a series of economic, socio-cultural, and racial challenges that shaped the highly-contingent and inescapably public activity of moviegoing in the county's rural, highly-decentralized, socially conservative, and racially discriminatory small-town communities. This study depicts local moviegoing as neither a ubiquitous nor fully accessible leisure activity due to: Local demographic factors that delayed the implementation of core commercial infrastructures and slowed the introduction and stabilization of local exhibitions until long after several notable exhibition trends that never meaningfully applied to Robeson had long since reshaped metropolitan moviegoing. The concerns of local civic and religious leaders that nearly resulted in the imposition of a cinema-censorship structure based on a legislative proposal during the 1921 General Assembly that had been co-sponsored by a Robeson County delegate. Local racial codes that sanctioned the tri-segregation of virtually all political, social, religious, and civic spaces, and which led Robeson's exhibitors and audiences (respectively) to construct or navigate aggressively segregated facilities whose locally paradigmatic form, the three-entrance theater, intentionally re-inscribed these codes within physical structures designed to perpetuate the second-class treatment of non-whites.Doctor of Philosoph

    The DELTA MONSTER: An RPV designed to investigate the aerodynamics of a delta wing platform

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    The mission requirements for the performance of aerodynamic tests on a delta wind planform posed some problems, these include aerodynamic interference; structural support; data acquisition and transmission instrumentation; aircraft stability and control; and propulsion implementation. To eliminate the problems of wall interference, free stream turbulence, and the difficulty of achieving dynamic similarity between the test and actual flight aircraft that are associated with aerodynamic testing in wind tunnels, the concept of the remotely piloted vehicle which can perform a basic aerodynamic study on a delta wing was the main objective for the Green Mission - the Delta Monster. The basic aerodynamic studies were performed on a delta wing with a sweep angle greater than 45 degrees. These tests were performed at various angles of attack and Reynolds numbers. The delta wing was instrumented to determine the primary leading edge vortex formation and location, using pressure measurements and/or flow visualization. A data acquisition system was provided to collect all necessary data

    Suspected congenital hyperinsulinism in a Shiba Inu dog

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    A 3-month-old male intact Shiba Inu dog was evaluated for a seizure disorder initially deemed idiopathic in origin. Seizure frequency remained unchanged despite thera- peutic serum phenobarbital concentration and use of levetiracetam. The dog was documented to be markedly hypoglycemic during a seizure episode on reevaluation at 6 months of age. Serum insulin concentrations during hypoglycemia were 41 U/μL (reference range, 10-29 U/μL). The dog was transitioned to 4 times per day feeding, diazoxide was started at 3.5 mg/kg PO q8h, and antiepileptic drugs were discon- tinued. No clinically relevant abnormalities were identified on bicavitary arterial and venous phase contrast computed tomographic imaging. The dog remained seizure- free and clinically normal at 3years of age while receiving 5.5 mg/kg diazoxide PO q12h and twice daily feeding. Seizures later occurred approximately twice per year and after exertion, with or without vomiting of a diazoxide dose. Blood glucose curves and interstitial glucose monitoring were used to titrate diazoxide dose and dosing interval. Congenital hyperinsulinism is well recognized in people but has not been reported in veterinary medicine

    STORMTOOLS, Coastal Environmental Risk Index (CERI) Risk and Damage Assessment App

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    STORMTOOLS Coastal Environmental Risk Index (CERI) predicts the coastal flooding damage to individual structures using coastal flooding levels, including the effects of sea level rise (SLR), provided in terms of the base flood elevation (BFE), specifications of the structure of interest (type and first floor elevation) and the associated damage functions from the U.S. Army Corp of Engineers (USACE), North Atlantic Coast Comprehensive Study (NACCS). CERI has been applied to selected coastal communities in Rhode Island, including those in Narragansett Bay and along the southern Rhode Island shoreline. Users can access the results of CERI via ArcGIS online at the CERI website. The objective of this effort was to develop, test, distribute, and evaluate a mobile phone application (App) that allows the user to assess the risk from coastal flooding and the associated damage at the individual structure level using the CERI methodology. The App is publicly available and has been developed for both iOS and Android operating systems. Environmental data to support the App, in terms of 100 y flood BFE maps, including the effects of SLR and the selected site grade elevation, are provided in the application by the URI Environmental Data Center (EDC). The user enters the location and type of the structure of interest (residential number of stories, with or without basement, pile supported or commercial building and the first-floor elevation (FFE)) and the desired SLR. The App then calculates the percent structural damage based on the specified environmental conditions and structure specifications. The App can be applied to any structure at any coastal location within the state. The CERI App development project has been guided by an Advisory Board made up of key constituents involved in coastal management and development in the state. The effort included extensive testing of the App by various user groups. The App structure makes it simple and straightforward to transfer to coastal and inland flooded areas in other locations, requiring only the specification of BFEs and grade elevations

    Asymmetric Proteome Equalization of the Skeletal Muscle Proteome Using a Combinatorial Hexapeptide Library

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    Immobilized combinatorial peptide libraries have been advocated as a strategy for equalization of the dynamic range of a typical proteome. The technology has been applied predominantly to blood plasma and other biological fluids such as urine, but has not been used extensively to address the issue of dynamic range in tissue samples. Here, we have applied the combinatorial library approach to the equalization of a tissue where there is also a dramatic asymmetry in the range of abundances of proteins; namely, the soluble fraction of skeletal muscle. We have applied QconCAT and label-free methodology to the quantification of the proteins that bind to the beads as the loading is progressively increased. Although some equalization is achieved, and the most abundant proteins no longer dominate the proteome analysis, at high protein loadings a new asymmetry of protein expression is reached, consistent with the formation of complex assembles of heat shock proteins, cytoskeletal elements and other proteins on the beads. Loading at different ionic strength values leads to capture of different subpopulations of proteins, but does not completely eliminate the bias in protein accumulation. These assemblies may impair the broader utility of combinatorial library approaches to the equalization of tissue proteomes. However, the asymmetry in equalization is manifest at either low and high ionic strength values but manipulation of the solvent conditions may extend the capacity of the method

    Nuclear Receptor Signaling Atlas (): hyperlinking the nuclear receptor signaling community

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    The nuclear receptor signaling (NRS) field has generated a substantial body of information on nuclear receptors, their ligands and coregulators, with the ultimate goal of constructing coherent models of the biological and clinical significance of these molecules. As a component of the Nuclear Receptor Signaling Atlas (NURSA)—the development of a functional atlas of nuclear receptor biology—the NURSA Bioinformatics Resource is developing a strategy to organize and integrate legacy and future information on these molecules in a single web-based resource (). This entails parallel efforts of (i) developing an appropriate software framework for handling datasets from NURSA laboratories and (ii) designing strategies for the curation and presentation of public data relevant to NRS. To illustrate our approach, we have described here in detail the development of a web-based interface for the NURSA quantitative PCR nuclear receptor expression dataset, incorporating bioinformatics analysis which provides novel perspectives on functional relationships between these molecules. We anticipate that the free and open access of the community to a platform for data mining and hypothesis generation strategies will be a significant contribution to the progress of research in this field

    Fate of ZnO nanoparticles in soils and cowpea (Vigna unguiculata)

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    The increasing use of zinc oxide nanoparticles (ZnO-NPs) in various commercial products is prompting detailed investigation regarding the fate of these materials in the environment. There is, however, a lack of information comparing the transformation of ZnO-NPs with soluble Zn2+ in both soils and plants. Synchrotron-based techniques were used to examine the uptake and transformation of Zn in various tissues of cowpea (Vigna unguiculata (L.) Walp.) exposed to ZnO-NPs or ZnCI2 following growth in either solution or soil culture. In solution culture, soluble Zn (ZnCI2) was more toxic than the ZnO-NPs, although there was substantial accumulation of ZnO-NPs on the root surface. When grown in soil, however, there was no significant difference in plant growth and accumulation or speciation of Zn between soluble Zn and ZnO-NP treatments, indicating that the added ZnO-NPs underwent rapid dissolution following their entry into the soil. This was confirmed by an incubation experiment with two soils, in which ZnO-NPs could not be detected after incubation for 1 h. The speciation of Zn was similar in shoot tissues for both soluble Zn and ZnO-NPs treatments and no upward translocation of ZnO-NPs from roots to shoots was observed in either solution or soil culture. Under the current experimental conditions, the similarity in uptake and toxicity of Zn from ZnO-NPs and soluble Zn in soils indicates that the ZnO-NPs used in this study did not constitute nanospecific risks

    A Close Companion Search Around L Dwarfs Using Aperture Masking Interferometry and Palomar Laser Guide Star Adaptive Optics

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    We present a close companion search around 16 known early L dwarfs using aperture masking interferometry with Palomar laser guide star adaptive optics (LGS AO). The use of aperture masking allows the detection of close binaries, corresponding to projected physical separations of 0.6-10.0 AU for the targets of our survey. This survey achieved median contrast limits of ΔK ~ 2.3 for separations between 1.2λ/D-4λ/D and ΔK ~ 1.4 at 2/3λ/D. We present four candidate binaries detected with moderate-to-high confidence (90%-98%). Two have projected physical separations less than 1.5 AU. This may indicate that tight-separation binaries contribute more significantly to the binary fraction than currently assumed, consistent with spectroscopic and photometric overluminosity studies. Ten targets of this survey have previously been observed with the Hubble Space Telescope as part of companion searches. We use the increased resolution of aperture masking to search for close or dim companions that would be obscured by full aperture imaging, finding two candidate binaries. This survey is the first application of aperture masking with LGS AO at Palomar. Several new techniques for the analysis of aperture masking data in the low signal-to-noise regime are explored
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