767 research outputs found

    Italian Household Wealth: Background, Main Results, Outlook

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    The paper offers a broad overview of the topics addressed during the Bank of Italy's conference on Household wealth in Italy held in Perugia (Italy) in 2007. It recalls the principal reasons for central bank involvement in the compilation of statistics on wealth, looks at the Bank of Italy's experience in this specific field, provides a brief synopsis of the research to date and compares the new estimates with those previously available. The final section provides some thoughts on the future direction of the research.Households, Wealth, Saving

    Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells

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    BACKGROUND: Keratinocyte growth factor receptor (KGFR) is a splice variant of the FGFR2 gene expressed in epithelial cells. Activation of KGFR is a key factor in the regulation of physiological processes in epithelial cells such as proliferation, differentiation and wound healing. Alterations of KGFR signaling have been linked to the pathogenesis of different epithelial tumors. It has been also hypothesized that its specific ligand, KGF, might contribute to the development of resistance to 5-fluorouracil (5-FU) in epithelial cancers and tamoxifen in estrogen-positive breast cancers. METHODOLOGY/PRINCIPAL FINDINGS: Small interfering RNA was transfected into a human keratinocyte cell line (HaCaT), a breast cancer derived cell line (MCF-7) and a keratinocyte primary culture (KCs) to induce selective downregulation of KGFR expression. A strong and highly specific reduction of KGFR expression was observed at both RNA (reduction = 75.7%, P = 0.009) and protein level. KGFR silenced cells showed a reduced responsiveness to KGF treatment as assessed by measuring proliferation rate (14.2% versus 39.0% of the control cells, P<0.001) and cell migration (24.6% versus 96.4% of the control cells, P = 0.009). In mock-transfected MCF-7 cells, KGF counteracts the capacity of 5-FU to inhibit cell proliferation, whereas in KGFR silenced cells KGF weakly interferes with 5-FU antiproliferative effect (11.2% versus 28.4% of the control cells, P = 0.002). The capacity of 5-FU to induce cell death is abrogated by co-treatment with KGF, whereas in KGFR silenced cells 5-FU efficiently induces cell death even combined to KGF, as determined by evaluating cell viability. Similarly, the capacity of tamoxifen to inhibit MCF-7 and KCs proliferation is highly reduced by KGF treatment and is completely restored in KGFR silenced cells (12.3% versus 45.5% of the control cells, P<0.001). CONCLUSIONS/SIGNIFICANCE: These findings suggest that selective inhibition of the KGF/KGFR pathway may provide a useful tool to ameliorate the efficacy of the therapeutic strategies for certain epithelial tumors

    Italian Household Wealth: Background, Main Results, Outlook

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    The paper offers a broad overview of the topics addressed during the Bank of Italy's conference on Household wealth in Italy held in Perugia (Italy) in 2007. It recalls the principal reasons for central bank involvement in the compilation of statistics on wealth, looks at the Bank of Italy's experience in this specific field, provides a brief synopsis of the research to date and compares the new estimates with those previously available. The final section provides some thoughts on the future direction of the research

    Italian Household Wealth: Background, Main Results, Outlook

    Get PDF
    The paper offers a broad overview of the topics addressed during the Bank of Italy's conference on Household wealth in Italy held in Perugia (Italy) in 2007. It recalls the principal reasons for central bank involvement in the compilation of statistics on wealth, looks at the Bank of Italy's experience in this specific field, provides a brief synopsis of the research to date and compares the new estimates with those previously available. The final section provides some thoughts on the future direction of the research

    Proclama Li governatori interinali, che secondo le forme del cessato Veneto governo sono stati repristinati in Crema per ordine militare proseguiranno provvisoriamente, e fino a nuova sovrana disposizione nel loro impiego ..

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    1 manifesto : 1 stemma ; fol Data di emanazione in calce: Milano 10. maggio 1799 Data di stampa presunta: 1799 (emanazione) Firmatario in calce: Cocastelli commissario generale civile In testa stemma xilo

    Avviso E' piaciuto a S.E. il sig. co. Cocastelli commissario imperiale di approvare con lettera 5. corrente l'erezione di un tribunale di seconda istanza per questa provincia ..

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    1 manifesto : 1 stemma ; 38 cm Data di emanazione in calce: li 10. agosto 1799 Data di stampa presunta: 1799 (emanazione) Firmatari in calce In testa stemma xilog

    Proclama Lo straordinario incariemento de' grani tanto più riflessibile negli attuali impegni d'una maggiore consumazione ha eccitato lo zelo della congregazione delegata di Milano ..

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    1 manifesto : 1 stemma ; 50 cm Data di emanazione in calce: Milano 20. dicembre 1799 Data di stampa presunta: 1799 (emanazione) Firmatario in calce: Cocastelli commissario imperiale In testa stemma xilogr Testo disposto su 2 colonn

    D'ordine di sua eccellenza co. Cocastelli commissario regio imperiale in Milano il regio tribunale di polizia in Crema

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    1 manifesto : 1 stemma ; fol Data di emanazione in calce: [Crema] 19. novembre 1799 Data di stampa presunta: 1799 (emanazione) Incipit del testo: Con il presente pubblico proclama fa pubblicamente intendere, e sapere a chiunque, purchè non sia reo principale, che dasse notizia al tribunale di qualche club Firmatari in calce In testa stemma xilog

    Fingerprinting the Hydration Products of Hydraulic Binders Using Snapshots from Time-Resolved In Situ Multinuclear MAS NMR Spectroscopy

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    The very early hydration behavior of a hydraulic binder phase, ye'elimite, Ca4Al6O12SO4, in the absence and in the presence of calcium sulfate, has been investigated. A time-resolved in situ multin..

    Local survelance study on etiology of community-and hospital-acquired urinary tract infections (UTI) and antimicrobial susceptibility of uropathogens

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    This study was conduced during October 2010-March 2011 with the collaboration of the microbiology laboratory of International Evangelical Hospital (Voltri division) to identify the most frequent pathogens isolates from Urinary Tract Infections (UTI) and to evaluate their antibiotics susceptibility patterns. Overall, 780 consecutive, non duplicate strains were collected and sent to the coordinating laboratory. 143 strains were from Healthcare settings and 637 from comunity acqueired infections.The most rappresented pathogens was E. coli. In our region the epidemiological community landscape in terms of resistance, is getting closer to the nosocomial setting
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