202 research outputs found

    Stereoview of C2′- and C1′- AAF-dG structures, superimposed on the base and AAF moiety

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    <p><b>Copyright information:</b></p><p>Taken from "A new conformation for -(deoxyguanosin-8-yl)-2-acetylaminofluorene (AAF-dG) allows Watson–Crick pairing in the P2 DNA polymerase IV (Dpo4)"</p><p>Nucleic Acids Research 2006;34(3):785-795.</p><p>Published online 1 Feb 2006</p><p>PMCID:PMC1360743.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> The C1′- AAF-dG is taken from the last snapshot of the 1-AAF-dG:-dCTP trajectory ( = 120.4°). The C2′- AAF-dG ( = 162.0 °) differs from the C1′- AAF-dG only in the sugar pucker pseudorotation angle, (,). Other torsions are χ = 201.8°, α′ = 101.0°, β′ = 30.7° and γ′ = 33.6°. The nucleotides are colored by atom with the AAF moiety shown in red and the methyl of the acetyl group in cyan. For clarity hydrogen atoms are not shown. Collision is denoted by the red circle

    sj-docx-1-onc-10.1177_11795549221123620 – Supplemental material for Prognostic Values From Integrated Analysis of the Nomogram Based on RNA-Binding Proteins and Clinical Factors in Endometrial Cancer

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    Supplemental material, sj-docx-1-onc-10.1177_11795549221123620 for Prognostic Values From Integrated Analysis of the Nomogram Based on RNA-Binding Proteins and Clinical Factors in Endometrial Cancer by Shuang Yuan, Xiao Sun and Lihua Wang in Clinical Medicine Insights: Oncology</p

    Visual outcomes of dense pediatric cataract surgery in eastern China

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    <div><p>Purpose</p><p>To evaluate the visual outcomes of dense pediatric cataract surgery in eastern China.</p><p>Methods</p><p>Medical records of children who underwent surgery for dense unilateral or bilateral pediatric cataract in Shandong Provincial Hospital between January 2007 and December 2012 were collected. Patients who cooperated with optical correction and aggressive patching of the sound eye and who had a minimum postoperative follow-up of more than 2 years were included. Risk factors for poor visual outcomes were analyzed.</p><p>Results</p><p>Of the 105 eligible patients (181 eyes), 76 had bilateral cataract, and 29 unilateral. With a mean follow up of 46.77 mo (range 24.0~96.0 mo), the final best corrected visual acuity (BCVA) of 158 eyes were recorded, and 4.43% (7/158) achieved 0.1 logarithm of the minimum angle of resolution (logMAR) or better; 15.19% (24/158) obtained a BCVA between 0.1 logMAR and 0.3 logMAR; 18.99%, (30/158) between 0.3 logMAR and 0.5 logMAR; 46.84% (74/158), between 0.5 logMAR and 1 logMAR; 14.55%, worse than 1 logMAR. The mean BCVA of the patients who underwent lensectomy before 3 months of age was significantly better than that of patients who underwent lensectomy between 3 and 12 months (p = 0.001). In the same lensectomy age groups, the final BCVA of the children in the bilateral and unilateral groups did not differ significantly (P>0.05). Lensectomy after 3 months of age, postoperative complications, strabismus and nystagmus were shown to be risk factors for poor visual outcomes.</p><p>Conclusions</p><p>Lensectomy before 3 months of age, IOL implantation, proper managing of postoperative complications, early optical correction and aggressive postoperative patching of the sound eye would increase the final BCVA for patients with dense pediatric cataract.</p></div

    A 55-year-old man with a MIA in the upper lobe of left lung.

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    <p>Axial (A) and coronal (B) HRCT images show a 13.2mm irregular nodule with spiculated margin (arrow), and intact vessels through lesion with tiny branches (coarse arrow).</p

    The performance of PrMFTP and their variants on the test set.

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    The highest value is highlighted in bold. w/o is abbreviation of without. The mean ± standard deviation on 5-fold cross-validation is shown for models. *, **, *** and **** mean that PrMFTP is significantly better at P-value < 0.05, P-value < 0.01, P-value < 0.001 and P-value < 0.0001 (t-test), respectively.</p

    HRCT morphologic features of lung pre-invasive lesion and MIA.

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    <p>HRCT morphologic features of lung pre-invasive lesion and MIA.</p

    Incidence of serious long-term complications.

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    <p>Incidence of serious long-term complications.</p

    Receiver operating characteristic (ROC) curve for HRCT variables.

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    <p>The area under ROC curve (AUC) for lesion diameter was 0.760 (A), the AUC for mean HRCT attenuation 0.793 (B), and the AUC for lesion volume 0.898 (C). The optimal cut-off value used for lesion diameter, mean HRCT attenuation and volume to differentiate pre-invasive lesions from MIA was 8.18 mm (sensitivity, 75.0%; specificity, 71.8%; PPV, 44.8%; and NPV, 52.7%), -602 HU (sensitivity, 71.4%; specificity, 76.9%; PPV, 49.1%; and NPV, 50.6%), and 0.33 cm3 (sensitivity, 78.6%; specificity, 87.2%; PPV, 51.9%; and NPV, 48.8%), separately.</p

    Nodule contouring process.

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    <p>(A) The edge of the nodule is traced automatically. (B) The segmented nodule shows different colour in the two-dimensional colour mapping.</p

    Can we differentiate minimally invasive adenocarcinoma and non-invasive neoplasms based on high-resolution computed tomography features of pure ground glass nodules? - Fig 5

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    <p>A 55-year-old woman with an AIS in the upper lobe of left lung. Axial (A) and colour mapping (B) images show a pure GGN. The 6mm nodule shows an oval shape, a smooth border, and vessels through with tiny branches (coarse arrow).</p
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