32 research outputs found

    FATORES ASSOCIADOS AO DESENVOLVIMENTO DA S√ćNDROME DE BURNOUT EM POLICIAIS MILITARES DE IMPERATRIZ-MA

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    S√≠ndrome do burnout (SB) √© um fen√īmeno relacionado a respostas organismo a fatores estressores presentes no ambiente laboral. A Policia Militar (PM) √© a primeira linha no combate √† criminalidade. Nesse sentido, suas condi√ß√Ķes de trabalho podem exp√ī-los sofrimento ps√≠quico e emerg√™ncia desta doen√ßa. O objetivo do estudo foi elucidar as principais caracter√≠sticas da PM de Imperatriz-MA relacionadas a SB. A pesquisa teve car√°ter transversal e anal√≠tico. Foi aplicado um question√°rio abordando quest√Ķes sociodemogr√°ficas e sobre exaust√£o emocional. A an√°lise das vari√°veis foi feita utilizando frequ√™ncias absoluta e relativas e as associa√ß√Ķes realizadas atrav√©s do teste qui-quadrado. Como resultados obteve-se que 36,29% dos entrevistados tinham possibilidade de desenvolver SB; 12,90% haviam sinais de instala√ß√£o da s√≠ndrome e 8,06% poderiam estar em fase consider√°vel da doen√ßa. A maioria dos policiais que possu√≠am algum indicio da SB eram casados ou em uni√£o est√°vel (31,5%) e possu√≠am mais que 4 anos de atua√ß√£o (27,4%), ademais notou-se que ocorr√™ncia de sintomas era mais significante no sexo masculino (40,3%). Os dados contribu√≠ram para fortalecer a necessidade de uma aten√ß√£o especial para a popula√ß√£o estudada. Portanto, sendo o burnout uma doen√ßa decorrente do estresse laboral, precisa ser combatido de maneira incisiva.ABSTRACTBurnout syndrome (BS) is a phenomenon related to organism responses to stressors present in the work environment. The Military Police (MP) is the first line in the fight against crime. In this sense, their working conditions can expose them to the psychological suffering and emergence of this disease. The objective of the study was to elucidate the main characteristics of MP of Imperatriz-MA related to BS. The research was transversal and analytical. A questionnaire was applied addressing sociodemographic issues and emotional exhaustion. Variables were analyzed using absolute and relative frequencies and associations performed using the chi-square test. As a result, it was obtained that 36.29% of the interviewees had the possibility of developing BS; 12.90% had signs of the syndrome, and 8.06% could be at a considerable stage of the disease. The majority of the participants who had some indication of BS were married or in a stable union (31.5%) and had more than 4 years of service (27.4%). In addition, it was noticed that the occurrence of symptoms was more significant in the sex male (40.3%). The data contributed to strengthening the need for special attention to the population studied. Therefore, since burnout is a disease due to¬†occupational stress, it must be tackled in an incisive manner

    Educomunicação em Tempos de Pandemia:

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    Os textos que comp√Ķem esta obra s√£o oriundos do VIII Col√≥quio Ibero-americano de Educomunica√ß√£o (VIII CIEducom) e IX Col√≥quio Catarinense de Educomunica√ß√£o (IX CCEducom), realizados em mar√ßo de 2021. Em um ano no qual o v√≠rus SARS-CoV-2 e variantes circularam por diversos territ√≥rios, Educomunica√ß√£o em tempos de pandemia: pr√°ticas e desafios foi o tema discutido nos eventos. Este livro colocado √† disposi√ß√£o do p√ļblico √© um modo de compartilhar caminhos e convidar pessoas curiosas a percorrerem, por meio das palavras e recursos gr√°ficos, desafios identificados e estrat√©gias para o enfrentamento deste inesperado per√≠odo de pandemia

    New records of mosquito species (Diptera: Culicidae) for Bahia (Brazil)

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    Federal University of Piau√≠ State - Professora Cinobelina Elvas. Bom Jesus, PI, Brazil / Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Programa de P√≥s-Gradua√ß√£o em Virologia. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Centro de Inova√ß√Ķes Tecnol√≥gicas. Ananindeua, PA, Brasil.Saint Louis Zoo. Institute for Conservation Medicine. Saint Louis, MO, USA.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Programa de P√≥s-Gradua√ß√£o em Virologia. Ananindeua, PA, Brasil.We provide seven new identified mosquitoes in the Bahia State, Brazil: Coquillettidia nigricans, Johnbelkinia longipes, Limatus pseudomethysticus, Psorophora albipes, Sabethes belisarioi, Sabethes cyaneus and Sabethes quasicyaneus. This new finding which expands the known distribution of these seven species of mosquitoes, is of great importance as we work for the development of preventive measures for arboviruses in Brazil and globally. In other regions of the world, the culicids we report are known vectors of important arboviruses of human and non-human animal concern, including yellow fever, Saint Louis encephalitis, equine encephalitis, Guama, Una, Mayaro, wyeomyia and Kairi viruses, and may play a role in the epidemiology of these diseases in Bahia as well. Our work also highlights the paucity of data on the insect diversity in different environments in Brazil

    Near-complete genome of cosavirus A from a child hospitalized with acute gastroenteritis, Brazil

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    Foundation for Scientific and Technological Development in Health (FIOTEC) Project PRES-012-FIO-16. CNPq grant 304781/2019-3.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Programa de P√≥s-Gradua√ß√£o em Virologia. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Programa de P√≥s-Gradua√ß√£o em Virologia. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Acute gastroenteritis (AG) is responsible for 525,000 deaths worldwide in children under-5-years and is caused by the Human Cosavirus (HCoSV; family Picornaviridae, Genus Cosavirus). Although its health importance, a significant percentage of diarrhea cases (‚Čą 40 %) still of unknown etiology. In Brazil, few studies have reported HCoSV-A sequences analyzing partial 5' UTR. This study characterized the first near-complete genome of a Cosavirus A (strain AM326) from a child hospitalized with AG in Amazonas state, Northern Brazil. High throughput sequencing (HTS) was performed using the HiSeq‚ĄĘ 2500 platform (Illumina) in one fecal specimen collected from the Surveillance of Rotavirus Network of the Evandro Chagas Institute collected in 2017. Sequence reads were assembled by the De Novo approach using three distinct algorithmic (IDBA-UD, Spades, and MegaHit). The final contig was recovered from the HCoSV-AM326 sample revealing 7,735 nt in length (SRA number SRR12535029; GenBank MT023104) and the genetic characterization, as well as phylogenetic analysis demonstrated a new variant strain from Brazil, highlighting the association of HCoSV-A as a possible causative agent of AG. This finding demonstrates the importance of the metagenomic approach to elucidate cases of diarrhea without a defined etiology, as well as providing a better understanding about the virus genetics, evolution and epidemiology

    Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon

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    Coordena√ß√£o de Aperfei√ßoamento de Pessoal de N√≠vel Superior (CAPES - grant number 3274/2013) and National Council for Scientific and Technological Development (CNPq - grant number 302584/2015-3). NRF was supported by a Wellcome Trust and Royal Society Sir Henry Dale Fellowship (204311/Z/16/Z) and by a Medical Research Council-S√£o Paulo Research Foundation (FAPESP) CADDE partnership award (MR/S0195/1 and FAPESP 18/14389-0)Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Par√°. Bel√©m, PA, Brazil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.University of S√£o Paulo. Faculty of Public Health. S√£o Paulo, SP, Brazil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.University of Oxford. Department of Zoology. Oxford, UK.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.The existence of sylvatic transmission of dengue virus in communities of neotropical bats remains uncertain. In this work we present a near-complete genome of dengue virus serotype 4 obtained from the brain sample of a bat from Platyrrhinus helleri specie collected in the Brazilian Amazon region. The presence of the virus in the brain sample may indicate a possible tropism for the central nervous system in bats, which may justify negative results in previous studies that focused on analysis of other tissues, such as liver and spleen. Besides the duration of dengue virus circulation in the Americas (circa 40 years) may be too short for an implementation of a sylvatic dengue virus cycle. Our findings suggest that continued monitoring is needed to confirm with the neotropical bats could potentially act as a natural reservoir of dengue in the regio

    Characterization of mitochondrial genome of Haemagogus janthinomys (Diptera: Culicidae)

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    Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Centro de Inova√ß√Ķes Tecnol√≥gicas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Laborat√≥rio de Entomologia M√©dica. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Laborat√≥rio de Entomologia M√©dica. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Centro de Inova√ß√Ķes Tecnol√≥gicas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Centro de Inova√ß√Ķes Tecnol√≥gicas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Centro de Inova√ß√Ķes Tecnol√≥gicas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Centro de Inova√ß√Ķes Tecnol√≥gicas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Centro de Inova√ß√Ķes Tecnol√≥gicas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Centro de Inova√ß√Ķes Tecnol√≥gicas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Centro de Inova√ß√Ķes Tecnol√≥gicas. Ananindeua, PA, Brazil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Centro de Inova√ß√Ķes Tecnol√≥gicas. Ananindeua, PA, Brasil.Haemagogus janthinomys is a mosquito of high importance in public health due its involvement on natural wild cycles of two important arboviruses in the Brazilian Amazon region: Yellow Fever virus (Flaviviridae, Flavivirus) and Mayaro virus (Togaviridae, Alphavirus). Here, we have sequenced and described all the mitochondrial genes for the Hg. janthinomys species. The complete coding sequence is14‚ÄČ937‚ÄČbp long and includes 37 functional genes, of which 13 codes for proteins, 22 for tRNA and 2 for ribosomal subunits. Region A‚ÄČ+‚ÄČT (control region) is not presented here. The data should be helpful on further taxonomic and evolutionary studies of this important arbovirus vector

    First report of Biomphalaria tenagophila (d'Orbigny, 1835) (Gastropoda/Planorbidae) in Par√° State, Amazon region of Brazil

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    Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde e Ambiente. Instituto Evandro Chagas. Laborat√≥rio de Malacologia. Ananindeua, PA, Brasil / Universidade do Estado do Par√°. Programa de P√≥s-Gradua√ß√£o em Biologia Parasit√°ria na Amaz√īnia. Bel√©m, PA, Brazil.Funda√ß√£o Oswaldo Cruz. Instituto Ren√© Rachou. Grupo de Pesquisa em Helmintologia e Malacologia M√©dica. Belo Horizonte, MG, Brazil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade do Estado do Par√°. Programa de P√≥s-Gradua√ß√£o em Biologia Parasit√°ria na Amaz√īnia. Bel√©m, PA, Brazil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde e Ambiente. Instituto Evandro Chagas. Laborat√≥rio de Parasitoses Intestinais e Esquistossomose. Ananindeua, PA, Brasil.Introduction: Mollusks belonging to Biomphalaria genus are intermediate hosts of Schistosoma mansoni. In the Par√° State, Northern Region of Brazil, there are reports of B. glabrata, B. straminea, B. schrammi, B. occidentalis, and B. kuhniana occurrence. Here, we report for the first time the presence of B. tenagophila in Bel√©m, capital of Par√° state. Methods: A total of 79 mollusks were collected and examined to search for possible S. mansoni infection. The specific identification was made by morphological and molecular assays. Results: No specimens parasitized by trematode larvae were detected. For the first time the presence of B. tenagophila in Bel√©m, capital of Par√° state, was reported. Conclusion: The result increases the knowledge about Biomphalaria mollusks occurrence in the Amazon Region and specifically alerts on the possible role of B. tenagophila in schistosomiasis transmission in Bel√©m

    Immune escape mutations in HIV-1 controllers in the Brazilian Amazon region

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    This work was supported by grants from the Conselho Nacional de Desenvolvimento Cient√≠fico e Tecnol√≥gico ‚Äď CNPq (#301869/2017‚Äď0), Funda√ß√£o Amaz√īnia Paraense de Amparo a Estudos e Pesquisas (FAPESPA/ PRONEX-2015) and Universidade Federal do Par√° (PAPQ/2019).Federal University of Par√°. Biological Science Institute. Laboratory of Virology. Ananindeua, PA, Brazil / Federal University of Par√°. Biological Science Institute. Graduate Program in Biology of Infectious and Parasitic Agents. Ananindeua, PA, Brazil.Federal University of Par√°. Biological Science Institute. Laboratory of Virology. Ananindeua, PA, Brazil.Federal University of Par√°. Biological Science Institute. Laboratory of Virology. Ananindeua, PA, Brazil.Federal University of Par√°. Biological Science Institute. Laboratory of Virology. Ananindeua, PA, Brazil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Minist√©rio da Sa√ļde. Secretaria de Vigil√Ęncia em Sa√ļde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Par√°. Biological Science Institute. Laboratory of Virology. Ananindeua, PA, Brazil.Federal University of Par√°. Biological Science Institute. Laboratory of Virology. Ananindeua, PA, Brazil.Background: Human immunodeficiency virus (HIV-1) infection is characterized by high viral replication and a decrease in CD4+ T cells (CD4+TC), resulting in AIDS, which can lead to death. In elite controllers and viremia controllers, viral replication is naturally controlled, with maintenance of CD4+TC levels without the use of antiretroviral therapy (ART). Methods: The aim of the present study was to describe virological and immunological risk factors among HIV-1-infected individuals according to characteristics of progression to AIDS. The sample included 30 treatment-naive patients classified into three groups based on infection duration (> 6 years), CD4+TC count and viral load: (i) 2 elite controllers (ECs), (ii) 7 viremia controllers (VCs) and (iii) 21 nonviremia controllers (NVCs). Nested PCR was employed to amplify the virus genome, which was later sequenced using the Ion PGM platform for subtyping and analysis of immune escape mutations. Results: Viral samples were classified as HIV-1 subtypes B and F. Greater selection pressure on mutations was observed in the group of viremia controllers, with a higher frequency of immunological escape mutations in the genes investigated, including two new mutations in gag. The viral sequences of viremia controllers and nonviremia controllers did not differ significantly regarding the presence of immune escape mutations. Conclusion: The results suggest that progression to AIDS is not dependent on a single variable but rather on a set of characteristics and pressures exerted by virus biology and interactions with immunogenetic host factors

    Renal Dysfunction and Inflammatory Markers in Hypertensive Patients seen in a University Hospital

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    FUNDAMENTO: A doen√ßa renal cr√īnica representa hoje um grande desafio para a sa√ļde p√ļblica no sentido de se obterem conhecimentos para subsidiar interven√ß√Ķes que possam alterar a velocidade de perda da fun√ß√£o renal. OBJETIVO: Avaliar a magnitude do d√©ficit da fun√ß√£o renal em hipertensos adultos e sua rela√ß√£o com marcadores inflamat√≥rios: prote√≠na C reativa ultrassens√≠vel, velocidade de hemossedimenta√ß√£o e rela√ß√£o neutr√≥filos/linf√≥citos. M√ČTODOS: Estudo transversal envolvendo 1.273 adultos hipertensos, de ambos os sexos, sendo 1.052 com d√©ficit da fun√ß√£o renal e 221 sem d√©ficit, diagnosticados pela equa√ß√£o Modification of Diet in the Renal Disease. A raz√£o de chances (OR) e a raz√£o de preval√™ncia (RP) foram utilizadas para determinar a probabilidade de ocorr√™ncia de atividade inflamat√≥ria na doen√ßa renal. RESULTADOS: O d√©ficit de fun√ß√£o renal foi diagnosticado em 82,6% dos avaliados, sendo que a maioria da amostra (70,8%) estava inserida no est√°gio 2 da doen√ßa renal cr√īnica. No modelo de regress√£o permaneceram independentemente associadas ao d√©ficit da fun√ß√£o renal a s√≠ndrome metab√≥lica (RPajustada = 1,09 [IC95%: 1,04-1,14]), a prote√≠na C reativa ultrassens√≠vel (RPajustada = 1,54 [IC95%: 1,40-1,69]) e a velocidade de hemossedimenta√ß√£o (RPajustada = 1,20 [IC95%: 1,12-1,28]). No entanto, considerando os indiv√≠duos classificados no est√°gio 2 do d√©ficit da fun√ß√£o renal, a chance de altera√ß√£o dos marcadores inflamat√≥rios foram de OR = 10,25 (IC95%: 7,00-15,05) para a prote√≠na C reativa ultrassens√≠vel, OR = 8,50 (IC95%: 5.70-12.71) para a rela√ß√£o neutr√≥filos/linf√≥citos e OR = 7,18 (IC95%: 4,87-10,61) para a velocidade de hemossedimenta√ß√£o. CONCLUS√ÉO: Os resultados mostram associa√ß√£o da atividade inflamat√≥ria e da s√≠ndrome metab√≥lica com o d√©ficit da fun√ß√£o renal

    Disfunção renal e marcadores inflamatórios em hipertensos atendidos em hospital universitário Renal dysfunction and inflammatory markers in hypertensive patients seen in a university hospital

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    FUNDAMENTO: A doen√ßa renal cr√īnica representa hoje um grande desafio para a sa√ļde p√ļblica no sentido de se obterem conhecimentos para subsidiar interven√ß√Ķes que possam alterar a velocidade de perda da fun√ß√£o renal. OBJETIVO: Avaliar a magnitude do d√©ficit da fun√ß√£o renal em hipertensos adultos e sua rela√ß√£o com marcadores inflamat√≥rios: prote√≠na C reativa ultrassens√≠vel, velocidade de hemossedimenta√ß√£o e rela√ß√£o neutr√≥filos/linf√≥citos. M√ČTODOS: Estudo transversal envolvendo 1.273 adultos hipertensos, de ambos os sexos, sendo 1.052 com d√©ficit da fun√ß√£o renal e 221 sem d√©ficit, diagnosticados pela equa√ß√£o Modification of Diet in the Renal Disease. A raz√£o de chances (OR) e a raz√£o de preval√™ncia (RP) foram utilizadas para determinar a probabilidade de ocorr√™ncia de atividade inflamat√≥ria na doen√ßa renal. RESULTADOS: O d√©ficit de fun√ß√£o renal foi diagnosticado em 82,6% dos avaliados, sendo que a maioria da amostra (70,8%) estava inserida no est√°gio 2 da doen√ßa renal cr√īnica. No modelo de regress√£o permaneceram independentemente associadas ao d√©ficit da fun√ß√£o renal a s√≠ndrome metab√≥lica (RPajustada = 1,09 [IC95%: 1,04-1,14]), a prote√≠na C reativa ultrassens√≠vel (RPajustada = 1,54 [IC95%: 1,40-1,69]) e a velocidade de hemossedimenta√ß√£o (RPajustada = 1,20 [IC95%: 1,12-1,28]). No entanto, considerando os indiv√≠duos classificados no est√°gio 2 do d√©ficit da fun√ß√£o renal, a chance de altera√ß√£o dos marcadores inflamat√≥rios foram de OR = 10,25 (IC95%: 7,00-15,05) para a prote√≠na C reativa ultrassens√≠vel, OR = 8,50 (IC95%: 5.70-12.71) para a rela√ß√£o neutr√≥filos/linf√≥citos e OR = 7,18 (IC95%: 4,87-10,61) para a velocidade de hemossedimenta√ß√£o. CONCLUS√ÉO: Os resultados mostram associa√ß√£o da atividade inflamat√≥ria e da s√≠ndrome metab√≥lica com o d√©ficit da fun√ß√£o renal.BACKGROUND: Today, chronic kidney diseases represent a great challenge to public health as regards the acquisition of knowledge to support interventions that can slow the progression of renal function loss. OBJECTIVE: To analyze the magnitude of the renal function deficit in hypertensive adult patients and its relationship with the following inflammatory markers: high-sensitivity C reactive protein, erythrocyte sedimentation rate, and neutrophil/lymphocyte ratio. METHODS: Cross-sectional study including 1,273 adult hypertensive patients of both genders, of whom 1,052 had renal function deficit, and 221 had no deficit, as diagnosed by the Modification of Diet in Renal Disease equation. The odds ratio (OR) and the prevalence ratio (PR) were used to determine the probability of the occurrence of inflammatory activity in renal disease. RESULTS: Renal function deficit was diagnosed in 82.6% of the patients assessed, and most of the sample (70.8%) was classified as in stage 2 of chronic kidney disease. In the regression model, metabolic syndrome (PRadjusted = 1.09 [95%CI: 1.04-1.14]), high-sensitivity C reactive protein (PRadjusted = 1.54 [95%CI: 1.40-1.69]) and erythrocyte sedimentation rate (PRadjusted = 1.20 [95%CI: 1.12-1.28]) remained independently associated with the renal function deficit. However, considering the individuals classified as in stage 2 of renal function deficit, the chance of abnormalities in inflammatory markers were OR = 10.25 (95%CI: 7.00-15.05) for high-sensitivity C reactive protein, OR = 8.50 (95%CI: 5.70-12.71) for neutrophil/lymphocyte ratio, and OR = 7.18 (95%CI: 4.87-10.61) for erythrocyte sedimentation rate. CONCLUSION: The results show an association of inflammatory activity and metabolic syndrome with renal function deficit
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