18 research outputs found

    Climate change and insurance

    Get PDF
    This special collection examines insurance as an increasingly central mechanism in shaping how the effects of climate change are transforming local economies and ways of life. The papers study a range of exemplary cases, ranging from agricultural micro-insurance in development policy and regional sovereign risk facilities in the Caribbean to public and private insurance in the United States. This framing essay situates these papers in a longer tradition of scholarship on the government of risk and security. It also describes three themes that run through the papers: the economization of climate change; the moral economy of risk and responsibility; and the plasticity of insurance as an abstract technology that may be taken up in various governmental assemblages, in the name of various political projects

    Population sampling in longitudinal suverys

    Get PDF
    The paper questions the need for observational studies to achieve representativeness for real populations, in particular for longitudinal studies. It draws upon recent debates and argues for the need to distinguish scientific inference from population inference

    Population sampling in longitudinal suverys

    Get PDF
    In an opening paper Harvey Goldstein questions the need for observational studies to achieve representativeness for real populations, in particular for longitudinal studies. He draws upon recent debates and argues for the need to distinguish scientific inference from population inference. The points he raises are then debated in commentaries by Peter Lynn, Graciela Muniz-Terrera and Rebecca Hardy, Colm O'Muircheartaigh, Chris Skinner and Risto Lehtonen. These commentaries are followed by a response from Goldstein

    Classification and Regression Tree and Spatial Analyses Reveal Geographic Heterogeneity in Genome Wide Linkage Study of Indian Visceral Leishmaniasis

    Get PDF
    Genome wide linkage studies (GWLS) have provided evidence for loci controlling visceral leishmaniasis on Chromosomes 1p22, 6q27, 22q12 in Sudan and 6q27, 9p21, 17q11-q21 in Brazil. Genome wide studies from the major focus of disease in India have not previously been reported.We undertook a GWLS in India in which a primary ‚ąľ10 cM (515 microsatellites) scan was carried out in 58 multicase pedigrees (74 nuclear families; 176 affected, 353 total individuals) and replication sought in 79 pedigrees (102 nuclear families; 218 affected, 473 total individuals). The primary scan provided evidence (‚Č•2 adjacent markers allele-sharing LOD‚Č•0.59; nominal P‚ȧ0.05) for linkage on Chromosomes 2, 5, 6, 7, 8, 10, 11, 20 and X, with peaks at 6p25.3-p24.3 and 8p23.1-p21.3 contributed to largely by 31 Hindu families and at Xq21.1-q26.1 by 27 Muslim families. Refined mapping confirmed linkage across all primary scan families at 2q12.2-q14.1 and 11q13.2-q23.3, but only 11q13.2-q23.3 replicated (combined LOD‚Ää=‚Ää1.59; P‚Ää=‚Ää0.0034). Linkage at 6p25.3-p24.3 and 8p23.1-p21.3, and at Xq21.1-q26.1, was confirmed by refined mapping for primary Hindu and Muslim families, respectively, but only Xq21.1-q26.1 replicated across all Muslim families (combined LOD 1.49; P‚Ää=‚Ää0.0045). STRUCTURE and SMARTPCA did not identify population genetic substructure related to religious group. Classification and regression tree, and spatial interpolation, analyses confirm geographical heterogeneity for linkages at 6p25.3-p24.3, 8p23.1-p21.3 and Xq21.1-q26.1, with specific clusters of families contributing LOD scores of 2.13 (P‚Ää=‚Ää0.0009), 1.75 (P‚Ää=‚Ää0.002) and 1.84 (P‚Ää=‚Ää0.001), respectively.GWLS has identified novel loci that show geographical heterogeneity in their influence on susceptibility to VL in India

    New insights into the genetic etiology of Alzheimer's disease and related dementias

    Get PDF
    Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE őĶ4 allele

    Robust estimation of bacterial cell count from optical density

    Get PDF
    Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

    Jyväskylän kantakaupungissa sijaitsevien tilitoimistojen odotukset vastavalmistuneen taloushallinnon tradenomin taidoista

    No full text
    ‚Äč‚ÄčOpinn√§ytety√∂n taustalla on taloushallinnon ty√∂el√§m√§ss√§ vallitsevat muutokset, jotka koskevat niin ty√∂teht√§vi√§ kuin alan osaamisvaatimuksia. Taloushallinnon ala on jatkuvassa muutoksessa etenkin digitalisaation my√∂t√§. N√§in ollen alalla ty√∂skentelevien tulisi tunnistaa oma osaamisensa sek√§ uudistaa sit√§, jotta taidot vastaisivat ty√∂el√§m√§n vaatimuksia my√∂s tulevaisuudessa. Opinn√§ytety√∂ toteutettiin toimeksiantoja Suomen Taloushallintoliitto ry:lle. Opinn√§ytey√∂n tarkoituksena oli selvitt√§√§ millaisia taitoja vastavalmistuneet taloushallinnon tradenomit tarvitsevat siirtyess√§√§n ty√∂el√§m√§√§n. Lis√§ksi tarkoituksena oli selvitt√§√§ olisiko jotain erityistaitoja, joista olisi hy√∂ty√§ ty√∂el√§m√§ss√§. Osaamistarpeita kartoitettiin taloushallinnon alalla ty√∂skentelevien ammattilaisten n√§k√∂kulmasta. Teoreettinen viitekehys muodostui taloushallinnosta, osaamistarpeista taloushallinnon alalla sek√§ osaamisesta yleisesti. Opinn√§ytety√∂ toteutettiin laadullisena tutkimuksena ja aineistonkeruumenetelm√§n√§ k√§ytettiin s√§hk√∂ist√§ kyselylomaketta. Tutkimukseen osallistui 16:sta taloushallinnon ammattilaista, jotka ty√∂skenteliv√§t tilitoimistoissa Jyv√§skyl√§n kantakaupungin alueella. Tutkimustuloksien analyysimenetelm√§n√§ k√§ytettiin luokittelua, jotta saatiin esiin yleisimmin esiin nousseet vastaukset. Tutkimuksen tuloksista k√§vi ilmi, ett√§ taloushallinnon ammattilaiset odottavat vastavalmistuneelta tradenomilta erityisesti substanssiosaamista. Merkitt√§vin√§ taitoina vastauksien perusteella pidettiin my√∂s tietoteknist√§ osaamista, itsens√§ johtamisen taitoa sek√§ kyky√§ ja halua oppia uutta. Lis√§ksi tutkimustuloksissa usein toistui ongelmanratkaisukyky, vuorovaikutustaidot sek√§ kyky ty√∂skennell√§ stressin ja paineen alaisena.

    Doing Design Business in Japan: Experiences from Hirameki

    No full text
    Topics covered in this book focus on storytelling, practicalities and culture, design export platforms, and business models for entering the Japanese market. This book has been written for designers, design-intensive companies, students and researchers, and for everyone interested in Japan or design
    corecore