407 research outputs found

    Field Drawing of West Wall Profile of Unit A From Penny (8BR158)

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    This document is a field map drawing of the west wall profile of Unit A. It is a scan of original paper documents generated in the field

    Feature Paperwork of Feature A1-A4 From Penny (8BR158)

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    This file contain the field notes taken during the excavation of Test Unit A, pertaining to features A1 through A4. It is a scan of original paper documents generated in the field

    Feature Paperwork from Unit A at Penny (8BR158)

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    This file contain the field notes taken during phase II excavation

    How N.Y.’s Biggest For-Profit Nursing Home Group Flourishes Despite a Record of Patient Harm

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    How N.Y.\u27s Biggest For-Profit Nursing Home Group Flourishes Despite a Record of Patient Harm The state’s “character-and-competence” reviews are supposed to weed out operators with histories of violations and fines— but regulators don’t always act on the full story

    Muscarinic signaling influences the patterning and phenotype of cholinergic amacrine cells in the developing chick retina

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    <p>Abstract</p> <p>Background</p> <p>Many studies in the vertebrate retina have characterized the differentiation of amacrine cells as a homogenous class of neurons, but little is known about the genes and factors that regulate the development of distinct types of amacrine cells. Accordingly, the purpose of this study was to characterize the development of the cholinergic amacrine cells and identify factors that influence their development. Cholinergic amacrine cells in the embryonic chick retina were identified by using antibodies to choline acetyltransferase (ChAT).</p> <p>Results</p> <p>We found that as ChAT-immunoreactive cells differentiate they expressed the homeodomain transcription factors Pax6 and Islet1, and the cell-cycle inhibitor p27<sup>kip1</sup>. As differentiation proceeds, type-II cholinergic cells, displaced to the ganglion cell layer, transiently expressed high levels of cellular retinoic acid binding protein (CRABP) and neurofilament, while type-I cells in the inner nuclear layer did not. Although there is a 1:1 ratio of type-I to type-II cells <it>in vivo</it>, in dissociated cell cultures the type-I cells (ChAT-positive and CRABP-negative) out-numbered the type-II cells (ChAT and CRABP-positive cells) by 2:1. The relative abundance of type-I to type-II cells was not influenced by Sonic Hedgehog (Shh), but was affected by compounds that act at muscarinic acetylcholine receptors. In addition, the abundance and mosaic patterning of type-II cholinergic amacrine cells is disrupted by interfering with muscarinic signaling.</p> <p>Conclusion</p> <p>We conclude that: (1) during development type-I and type-II cholinergic amacrine cells are not homotypic, (2) the phenotypic differences between these subtypes of cells is controlled by the local microenvironment, and (3) appropriate levels of muscarinic signaling between the cholinergic amacrine cells are required for proper mosaic patterning.</p

    Shovel Test Pit Paperwork of Transect 8 from Quarterman (8BR223)

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    This document contains the field notes taken during phase 1 survey for transect 8

    Barriers Encountered by Syringe Exchange Clients in Vermont

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    Introduction and Aims. Vermont CARES is a nonprofit HIV prevention and advocacy organization which provides a needle exchange program for intravenous drug users. Services are focused on education, prevention, testing, and harm reduction. The Syringe Support Program (SSP) offers clients clean syringes to reduce intravenous transmission of disease. Although SSP are proven avenues for harm reduction, barriers prevent users from utilizing services. Clients are limited by social, economic, and personal obstacles de- scribed in similar populations across the country. This project seeks to identify the barriers Vermont CARES clients face in accessing the SSP, determine needs, and evaluate interest in additional services. Methods. Our team and Vermont CARES staff held a focus group with St. Johnsbury clients to discuss services and barriers. A 39 question paper survey was distributed to three Vermont CARES sites during October, 2017 by Vermont CARES. Participation was voluntary and uncompensated. Sixty-three clients completed the survey. Results and Discussion. Of the 63 respondents, 61.9% stated that lack of ade- quate income contributed most to their inability to meet basic needs. These same clients faced the most barriers to access with economic hardship precipitated by sub- stance abuse, disability, and family commitments. In assessing additional services, clients sought food pantries, hygiene kits, and dental clinics. 56.4% of respondents would use safe injection facilities if provided. Those without income to meet basic needs expressed most interest in safe injection facilities (p=0.022). With barriers recognized, our future aim is to track efficacy of new services in impacting care and quality of life.https://scholarworks.uvm.edu/comphp_gallery/1268/thumbnail.jp

    Patient preferences regarding prophylactic cranial irradiation: A discrete choice experiment

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    Introduction: In patients with non-small cell lung cancer (NSCLC) treated with chemoradiotherapy (CRT), prophylactic cranial irradiation (PCI) is not standard practice. This study determined patient preferences for PCI with respect to survival benefit, reduction in brain metastases (BM) and acceptable toxicity.  Methods: A Discrete Choice Experiment was completed pre- and post-treatment. Patients made 15 hypothetical choices between two alternative PCI treatments described by four attributes: amount of life gained, chance of BM, ability to care for oneself, and loss of memory. Participants also chose between PCI and no PCI.  Results: 54 and 46 surveys were completed pre- and post-treatment. The most important attributes pre-treatment were: a survival benefit >6 months, of 3–6 months, avoiding severe problems with memory and self-care, avoiding quite a bit of difficulty with memory and maximally reducing BM recurrence. Post-treatment, BM reduction became more important. 90% of patients would accept PCI for a survival benefit >6 months, with a maximal reduction in BM even if severe memory/self-care problems occurred. With a 10% reduction in BM and mild problems with memory and self-care 70% of patients pre- (90% post-treatment) would accept PCI for a survival benefit of 1–3 months, and 52% pre- (78% post-treatment) for no survival benefit.  Conclusion: Improvement in survival is the most important attribute of PCI with patients willing to accept significant toxicity for maximum survival and less toxicity for less survival benefit. BM reduction became more important after treatment. The majority of patients would accept PCI for no survival benefit and a reduction in BM

    Using Positive Deviance for Determining Successful Weight- Control Practices

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    Based on positive deviance (examining the practices of successful individuals), we identified five primary themes from 36 strategies that help to maintain long-term weight loss (weight control) in 61 people. We conducted in-depth interviews to determine what successful individuals did and/or thought about regularly to control their weight. The themes included weight-control practices related to (a) nutrition: increase water, fruit, and vegetable intake, and consistent meal timing and content; (b) physical activity: follow and track an exercise routine at least 3×/week; (c) restraint: practice restraint by limiting and/or avoiding unhealthy foods; (d) self-monitor: plan meals, and track calories/weight progress; and (e) motivation: participate in motivational programs and cognitive processes that affect weight-control behavior. Using the extensive data involving both the practices and practice implementation, we used positive deviance to create a comprehensive list of practices to develop interventions for individuals to control their weight

    Thermal breakage of window glass in room fires conditions - Analysis of some important parameters

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    In a compartment fire, the breakage and possible fallout of a window glass has a significant impact on the fire dynamics. The thermal breakage of glass depends on various parameters such as glass type, edge shading, edges conditions and constraints on the glass. The purpose of the present study is to investigate some of the key parameters affecting the thermal breakage of window glass in fire conditions using a recently developed and validated computer tool. Fallout is not within the scope of this study. Different boundary conditions of the glass pane (unconstrained and constrained) subjected to fire radiant heat are investigated. The analysis shows that to prevent glass thermal breakage, it is important to provide enough spacing between the frame and glass pane to accommodate the thermal expansion, and constraints on the glass structure should be avoided. The zones where the glass is likely to crack first are shown. The study also quantifies the effects of glass edge conditions on its thermal breakage in fire conditions; such analysis has not been reported in the literature due to its complexity and the statistical nature of edge flaws. The results show that an ordinary float glass mostly used in windows, with the “as-cut” edge condition would break later and is stronger than a ground edge or polished edge glass for the scenarios investigated. The study demonstrates how a predictive tool could be employed for a better understanding of thermal breakage of window glass in fires and for design guidance