14 research outputs found

    Variational Quantum Eigensolver for SU(NN) Fermions

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    Variational quantum algorithms aim at harnessing the power of noisy intermediate-scale quantum computers, by using a classical optimizer to train a parameterized quantum circuit to solve tractable quantum problems. The variational quantum eigensolver is one of the aforementioned algorithms designed to determine the ground-state of many-body Hamiltonians. Here, we apply the variational quantum eigensolver to study the ground-state properties of NN-component fermions. With such knowledge, we study the persistent current of interacting SU(NN) fermions, which is employed to reliably map out the different quantum phases of the system. Our approach lays out the basis for a current-based quantum simulator of many-body systems that can be implemented on noisy intermediate-scale quantum computers.Comment: 9 pages, 8 figure

    Remielinização em camundongos Knockout para conexina 32 desmielinizados experimentalmente

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    Este estudo visou avaliar o papel da conexina 32 (Cx 32) durante a remieliniza√ß√£o no sistema nervoso perif√©rico. Uma inje√ß√£o local de 0,1% de solu√ß√£o de brometo de et√≠dio foi realizada no nervo ci√°tico de camundongos deletados para a Cx 32, com eutan√°sia dos animais aos 1, 2, 3, 7, 15, 21 e 30 dias p√≥s-inje√ß√£o. Avalia√ß√Ķes histoqu√≠micas, imunoistoqu√≠micas, por imunofluoresc√™ncia e por microscopia eletr√īnica de transmiss√£o foram utilizadas na an√°lise do desenvolvimento das les√Ķes. Nos nervos ci√°ticos, c√©lulas de Schwann mostraram inicialmente sinais de intoxica√ß√£o e rejeitaram suas bainhas. Ap√≥s sete dias, observaram-se finas bainhas neoformadas, com compacta√ß√£o desigual e al√ßas redundantes (tom√°cula). Conclui-se que a regenera√ß√£o de bainhas de mielina perdidas no SNP seguiu o padr√£o j√° relatado deste modelo em outras esp√©cies de laborat√≥rio. Portanto, estes resultados sugerem que a aus√™ncia da Cx 32 n√£o interferiu com o padr√£o normal de remieliniza√ß√£o em camundongos jovens neste modeloThe aim of this study was to evaluate the role of connexin 32 (Cx 32) during remyelination of the peripheral nervous system, through a local injection of either 0,1% ethidium bromide solution or saline in the sciatic nerve of Cx 32 knockout mice. Euthanasia was performed ranging from 1, 2, 3, 7, 15, 21 to 30 days after injection. Histochemical, immunohistochemical, immunofluorescence and transmission electron microscopical techniques were used to analyze the development of the lesions. Within the sciatic nerves, Schwann cells initially showed signs of intoxication and rejected their sheaths; after seven days, some thin newly formed myelin sheaths with uneven compactness and redundant loops (tomacula) were conspicuous. We concluded that the regeneration of lost myelin sheaths within the PNS followed the pattern already reported for this model in other laboratory species. Therefore, these results suggest that absence of Cx 32 did not interfere with the normal pattern of remyelination in this model in young miceCNPq 475029/2004-6Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES

    The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

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    The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

    Finishing the euchromatic sequence of the human genome

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    The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ‚ąľ99% of the euchromatic genome and is accurate to an error rate of ‚ąľ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

    Converted seismic wave investigation in the Gulf of Corinth from local earthquakes

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    Comptes Rendus Géoscience, v. 336, n. 4-5, p. 259-267, 2004. http://dx.doi.org/10.1016/j.crte.2003.11.014International audienc

    Three-dimensional kinematic depth migration of converted waves: application to the 2002 Molise aftershock sequence (southern Italy)

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    International audienceMigration techniques, currently used in seismic exploration, are still scarcely applied in earthquake seismology due to the poor source knowledge and sparse, irregular acquisition geometries. At the crustal scale, classical seismological studies often perform inversions based on the arrival time of primary phases (P- and S-waves) but seldom exploit other information included in seismic records. Here we show how migration techniques can be adapted to earthquake seismology for converted wave analysis. As an example, we used data recorded by a dense local seismic network during the 2002 Molise aftershock sequence. In October and November 2002, two moderate magnitude earthquakes struck the Molise region (southern Italy), followed by an aftershock sequence lasting for about one month. Local earthquake tomography has provided earthquake hypocenter locations and three-dimensional models of P and S velocity fields. Strong secondary signals have been detected between first-arrivals of P- and S-waves and identified as SP transmitted waves. In order to analyse these waves, we apply a prestack depth migration scheme based on the Kirchhoff summation technique. Since source parameters are unknown, seismograms are equalized and only kinematic aspects of the migration process are considered. Converted wave traveltimes are calculated in the three-dimensional (3D) tomographic models using a finite-difference eikonal solver and back ray tracing. In the migrated images, the area of dominant energy conversion corresponds to a strong seismic horizon that we interpreted as the top of the Apulia Carbonate Platform and whose geometry and position at depth is consistent with current structural models from existing commercial seismic profiles, gravimetric and well dat

    Remyelination in experimentally demyelinated connexin 32 KnockOut mice Remielinização em camundongos KnockOut para conexina 32 desmielinizados experimentalmente

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    The aim of this study was to evaluate the role of connexin 32 (Cx 32) during remyelination of the peripheral nervous system, through a local injection of either 0,1% ethidium bromide solution or saline in the sciatic nerve of Cx 32 knockout mice. Euthanasia was performed ranging from 1, 2, 3, 7, 15, 21 to 30 days after injection. Histochemical, immunohistochemical, immunofluorescence and transmission electron microscopical techniques were used to analyze the development of the lesions. Within the sciatic nerves, Schwann cells initially showed signs of intoxication and rejected their sheaths; after seven days, some thin newly formed myelin sheaths with uneven compactness and redundant loops (tomacula) were conspicuous. We concluded that the regeneration of lost myelin sheaths within the PNS followed the pattern already reported for this model in other laboratory species. Therefore, these results suggest that absence of Cx 32 did not interfere with the normal pattern of remyelination in this model in young mice.<br>Este estudo visou avaliar o papel da conexina 32 (Cx 32) durante a remieliniza√ß√£o no sistema nervoso perif√©rico. Uma inje√ß√£o local de 0,1% de solu√ß√£o de brometo de et√≠dio foi realizada no nervo ci√°tico de camundongos deletados para a Cx 32, com eutan√°sia dos animais aos 1, 2, 3, 7, 15, 21 e 30 dias p√≥s-inje√ß√£o. Avalia√ß√Ķes histoqu√≠micas, imunoistoqu√≠micas, por imunofluoresc√™ncia e por microscopia eletr√īnica de transmiss√£o foram utilizadas na an√°lise do desenvolvimento das les√Ķes. Nos nervos ci√°ticos, c√©lulas de Schwann mostraram inicialmente sinais de intoxica√ß√£o e rejeitaram suas bainhas. Ap√≥s sete dias, observaram-se finas bainhas neoformadas, com compacta√ß√£o desigual e al√ßas redundantes (tom√°cula). Conclui-se que a regenera√ß√£o de bainhas de mielina perdidas no SNP seguiu o padr√£o j√° relatado deste modelo em outras esp√©cies de laborat√≥rio. Portanto, estes resultados sugerem que a aus√™ncia da Cx 32 n√£o interferiu com o padr√£o normal de remieliniza√ß√£o em camundongos jovens neste modelo
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