23 research outputs found

    Effectiveness of vero cell inactivated vaccine against severe acute respiratory infections (SARI) in Sibu, Malaysia: A retrospective test-negative design

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    The effectiveness of the vero cell inactivated vaccine (CoronaVac®) against severe acute respiratory infection (‎SARI)‎ caused by SARS-CoV-2 in the real world was assessed. A matched test-negative case-control design was employed using the web-based national information system, as well as the hospitalization dataset in Sibu Hospital. Vaccine effectiveness was measured by conditional logistic regression with adjustment for gender, underlying comorbidity, smoking status, and education level. Between 15 March and 30 September 2021, 838 eligible SARI patients were identified from the hospitalization records. Vaccine effectiveness was 42.4% (95% confidence interval [CI]: −28.3 to 74.1) for partial vaccination (after receiving the first dose to 14 days after receiving the second dose), and 76.5% (95% CI: 45.6 to 89.8) for complete vaccination (at 15 days or more after receiving the second dose). This analysis indicated that two doses of CoronaVac® vaccine provided efficacious protection against SARI caused by SARS-CoV-2 in the short term. However, the duration of protection, and performance against new variants need to be studied continuously

    Mobile Interactive System in Virtual Classroom based on TPACK: A Study from Students’ Perspectives

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    Journal of System and Management Sciences (JSMS) is a multidisciplinary journal, mainly publishes original research and applied papers on system and management sciences, including the application of system science and system engineering, mathematics and statistics, computer and information, operation research and the transition of education has occurred amidst the pandemic with the adoption of online teaching and learning. Even though technologies have been supporting online teaching and learning for years, the teachers’ proficiency in the virtual classroom is yet to be determined as it is still relatively new. Moreover, the teachers were incompetent to integrate technology into their pedagogy. Hence, a mobile interactive system (MIS) is designed with the adoption of technological pedagogical and content knowledge (TPACK) framework. It serves the purpose of enhancing the teachers’ online teaching experiences and effectiveness. Additionally, the proposed TPACK-based MIS framework was constructed via SMARTPLS v3.3.2. A research design of one-group pretest-posttest quasiexperimental was implemented to collect experimental sample data. The data were analyzed through the proposed framework. A moderating effect, an interacting effect on the relationship between TPACK and technological pedagogical knowledge (TPK) was observed through the analyzed results. Furthermore, the MIS is an essential moderator variable to enhance the teachers’ teaching effectiveness in the virtual classroom management, modeling and simulation

    Conditioned media of pancreatic cancer cells and pancreatic stellate cells induce myeloid-derived suppressor cells differentiation and lymphocytes suppression

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    Abstract As pancreatic cancer cells (PCCs) and pancreatic stellate cells (PSCs) are the two major cell types that comprise the immunosuppressive tumor microenvironment of pancreatic cancer, we aimed to investigate the role of conditioned medium derived from PCCs and PSCs co-culture on the viability of lymphocytes. The conditioned medium (CM) collected from PCCs and/or PSCs was used to treat peripheral blood mononuclear cells (PBMCs) to determine CM ability in reducing lymphocytes population. A proteomic analysis has been done on the CM to investigate the differentially expressed protein (DEP) expressed by two PCC lines established from different stages of tumor. Subsequently, we investigated if the reduction of lymphocytes was directly caused by CM or indirectly via CM-induced MDSCs. This was achieved by isolating lymphocyte subtypes and treating them with CM and CM-induced MDSCs. Both PCCs and PSCs were important in suppressing lymphocytes, and the PCCs derived from a metastatic tumor appeared to have a stronger suppressive effect than the PCCs derived from a primary tumor. According to the proteomic profiles of CM, 416 secreted proteins were detected, and 13 DEPs were identified between PANC10.05 and SW1990. However, CM was found unable to reduce lymphocytes viability through a direct pathway. In contrast, CM that contains proteins secreted by PCC and/or PSC appear immunogenic as they increase the viability of lymphocytes subtypes. Lymphocyte subtype treated with CM-induced MDSCs showed reduced viability in T helper 1 (Th1), T helper 2 (Th2), and T regulatory (Treg) cells, but not in CD8+ T cells, and B cells. As a conclusion, the interplay between PCCs and PSCs is important as their co-culture displays a different trend in lymphocytes suppression, hence, their co-culture should be included in future studies to better mimic the tumor microenvironment

    Modified TPACK Framework for Teachers’ Efficiency, Students’ Performance and Students’ Engagement

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    In the digital era, the environment of the classroom had gone through a drastic change where technology is slowly being introduced. Instead of conducting classes and lessons through the traditional or rather conventional way of teaching, the integration of educational technology in the classroom is being practiced recently. As teachers are the person who is being dedicated to deliver and transfer knowledge to students, their capabilities and abilities in conducting classes and lessons effectively are being spotlighted by society. Hence, for teachers to be well prepared in conducting classroom activities, a modified TPACK framework is proposed to assist teachers from seven aspects, which are technological knowledge, pedagogical knowledge and content knowledge, technological content knowledge, technological pedagogical knowledge, pedagogical content knowledge and last but not least technological pedagogical content knowledge since the thoroughness of teachers’ knowledge on the stated seven aspects will be affecting how they handled classes and lessons effectively. Since the existing TPACK framework in assessing teachers’ general knowledge about technology and how it interrelates with their pedagogical and content knowledge, the integration of the mobile interactive system with on-screen writing can further narrow down the scope focusing on how skillful and efficient are they to integrate mobile technology into classes and lessons. As a solution, this study found that the implementation of a mobile interactive system with an on-screen writing feature as the integration of educational technology in the classroom tailored for students who needed extra attention is effective in terms of preparing teaching plans and teaching materials. Therefore, this study will be resulting in different levels of teachers’ efficiency, students’ engagement and students’ performance in classroom teaching and learning. This study intends to identify how TPACK framework elements interrelate with each other and the relationship between modified framework and teachers’ efficiency, students’ performance and students’ engagement

    Nexus among blockchain visibility, supply chain integration and supply chain performance in the digital transformation era

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    Digital transformation (DT) in the semiconductor industry goes beyond traditional business operations and supply chain management (OSCM) to the digital world. Despite significant developments in recent years, blockchain implementations for OSCM remain relatively underdeveloped in the semiconductor industry. Therefore, this research aims to examine the relationships between blockchain visibility, supply chain integration (SCI) and supply chain performance (SCP) in the era of DT in Malaysia's semiconductor industry to shed light on this emerging area. Design/methodology/approach A convenience sampling of 71 operations and supply chain managers attached to semiconductor manufacturing firms in Malaysia were invited to participate in a survey. In assessing blockchain visibility within the industry, key terms namely business intelligence gathering, information exchange, information technology (IT) and knowledge of asset status, were conceptualised from the literature review. The questionnaires developed to collect data were validated by industry and academic experts. Findings The results from the analysis confirmed that SCI mediates the link between blockchain visibility (information exchange, business intelligence gathering and knowledge asset status) and SCP. Likewise, the importance-performance matrix analysis (IPMA) outcomes revealed that IT played a minor role. The results suggested that semiconductor manufacturers should pay less attention to IT since this was identified as having the least priority towards improvement. Practical implications The outcomes from this research enable policymakers to strategise and integrate blockchain technology in the era of DT to ensure sustainable SCM in the semiconductor industry in Malaysia. Originality/value The research bridge the knowledge gap by revealing the value that blockchain visibility can facilitate SCP and explore SCI as the prevailing factor and demonstrates how Resource-Based Theory and Network Theory can be applied in this study

    Synchronous Display and Whiteboard-Like Freehand Writing App as Teaching Tool for Virtual Classroom amidst the Pandemic

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    Purpose: The research evaluates if teachers can achieve better teaching outcomes by using a proposed mobile interactive system (MIS) developed for this study as an additional approach to enhancing teachers’ proficiency in Technological Pedagogical and Content Knowledge (TPACK) in the virtual classroom. Background: According to previous studies, teachers’ self-assessment on TPACK might be affected by their ego because they have autonomy over the students in the classroom. Some studies suggest that utilisation of an interactive whiteboard (IWB) promotes creativity in teaching and learning but that it is unsuitable for a virtual environment due to its large size and the high maintenance costs associated with owning one in a teacher’s residence. Besides, some studies also reveal that allowing the students to assess their teachers through TPACK is able to reduce potential errors which might result from the TPACK self-assessment done by teachers. Methods: Pre- and post- experiments were conducted with the developed MIS integrated into teaching process. Synchronous display (SD) and whiteboard-like freehand writing (WFW) were features of the MIS integrated into the experimental group. Questionnaires were distributed to the students, and a reflective measurement model was formed using SmartPLS and IBM SPSS Statistics. Findings: Based on our findings, teachers’ Technological Content Knowledge had a significant positive effect on TPACK with the inclusion of MIS in online teaching. Predictive relevance was also evaluated through a Q2 value to predict the endogenous construct of the constructed model. The Q2 value was greater than zero, indicating that the model possesses a predictive relevance. Conclusion: The integration of the developed MIS in the virtual classroom has a significant positive impact on the students’ academic performance relating to concept learning and knowledge acquisition of subject matter

    Proposed Integration of Mobile Interactive System in the Classroom

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    In the twenty-first century, there are many technologies available to assist us in our daily lives. One of the most commonly owned technology is mobile technology. Due to its nature of high mobility and easier to be owned, it has become a preferred education technology. Furthermore, the conventional way of teaching is still the mainstream among other approaches, which is ineffective. Hence, the introduction of the proposed mobile interactive system is aimed to make a change in the classroom environment for altering both the teaching and learning process. Teachers’ capabilities and abilities in facilitating classes using the mobile interactive system are somehow related to their prior technological knowledge, which is also one of the elements in the TPACK framework. Moreover, the TPACK framework is meant to assess a teacher’s level of understanding about technology and how the knowledge is being utilized and applied in their teaching plan and teaching materials. As a solution, this study discovered the mapping of teachers’ efficiency, students’ engagement and students’ performance into the TPACK framework can address the efficiency of the proposed mobile interactive system as an alternative mean for a teacher to deliver and transform knowledge to students. This study aims to integrate the proposed mobile interactive system in the TPACK framework and map with teachers’ efficiency, students’ engagement and students’ performance

    A Pedagogical Framework with Integration of TPACK for Mobile Interactive System in Teaching Mathematics

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    Although there is a variety of technology available in 21st century, the way classes and lesson being conducted are still mostly remaining the same which is teaching via one-way communication. One-way communication teaching process surfastces issues like lack of interaction where minimal discussion is going on during teaching session, Since the interaction between teachers and students are fairly poor, limited classroom activity can be expected such as “Question and Answer” which lead to the increment of boredom in classes and lessons among students. As the teaching process is leaning towards instructional, students’ feedback is usually being overlooked. Hence, since the availability of educational technology is getting more common nowadays, the integration of technology in classroom is encouraged changing the teaching and learning environment including knowledge delivery method from teacher perspective. Introducing mobile interactive system allows teachers deliver their knowledge differently, however, they are required to adapt and get familiar with the educational technology for improving teaching experience. Therefore, Technological Pedagogical Content Knowledge (TPACK) framework is applied in this paper to assess teachers using the seven elements of the framework. This paper is aimed to address the issues faced by conventional classroom and identify the effectiveness of teachers conducting classes using educational technology with the application of TPACK framework. Proposed TPACK framework is formed with the integration of three elements which are teachers’ efficiency, students’ performance and students’ engagement representing the outcome of current TPACK framework

    Measurement of the shape of the Bs0Dsμ+νμ {B}_s^0\to {D}_s^{\ast -}{\mu}^{+}{\nu}_{\mu } differential decay rate

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    International audienceThe shape of the Bs0Dsμ+νμ {B}_s^0\to {D}_s^{\ast -}{\mu}^{+}{\nu}_{\mu } differential decay rate is obtained as a function of the hadron recoil parameter using proton-proton collision data at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.7 fb1^{−1} collected by the LHCb detector. The Bs0Dsμ+νμ {B}_s^0\to {D}_s^{\ast -}{\mu}^{+}{\nu}_{\mu } decay is reconstructed through the decays DsDsγ {D}_s^{\ast -}\to {D}_s^{-}\gamma and DsKK+π {D}_s^{-}\to {K}^{-}{K}^{+}{\pi}^{-} . The differential decay rate is fitted with the Caprini-Lellouch-Neubert (CLN) and Boyd-Grinstein-Lebed (BGL) parametrisations of the form factors, and the relevant quantities for both are extracted.[graphic not available: see fulltext

    Collagen induces a more proliferative, migratory and chemoresistant phenotype in head and neck cancer via DDR1

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    Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and includes squamous cell carcinomas of the oropharynx and oral cavity. Patient prognosis has remained poor for decades and molecular targeted therapies are not in routine use. Here we showed that the overall expression of collagen subunit genes was higher in cancer-associated fibroblasts (CAFs) than normal fibroblasts. Focusing on collagen8A1 and collagen11A1, we showed that collagen is produced by both CAFs and tumour cells, indicating that HNSCCs are collagen-rich environments. We then focused on discoidin domain receptor 1 (DDR1), a collagen-activated receptor tyrosine kinase, and showed that it is over-expressed in HNSCC tissues. Further, we demonstrated that collagen promoted the proliferation and migration of HNSCC cells and attenuated the apoptotic response to cisplatin. Knockdown of DDR1 in HNSCC cells demonstrated that these tumour-promoting effects of collagen are mediated by DDR1. Our data suggest that specific inhibitors of DDR1 might provide novel therapeutic opportunities to treat HNSCC
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