425 research outputs found

    Site-Selective, Low-Loading, Au Nanoparticle–Polyaniline Hybrid Coatings with Enhanced Corrosion Resistance and Conductivity for Fuel Cells

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    Ultralow loading of Au nanoparticles (0.038 mg cm<sup>–2</sup>) and a polyaniline hybrid coating (AuNP-PANI) were deposited on stainless steel (SS316L) coupons. The unique two-step approach utilizing electrochemical deposition via cyclic voltammetry enabled growth of AuNPs in the fibrous PANI micropores thereby achieving enhanced surface coverage of SS316L and minimizing substrate corrosion via blocking of pores. The hybrid coatings revealed significantly low interfacial contact resistance values of 16.6 mΩ cm<sup>2</sup> (achieving the US DOE 2017 targets). Potentiodynamic tests revealed the excellent corrosion resistance of AuNP-PANI hybrid coatings with a corrosion potential of 0.61 V<sub>SHE</sub>, which is positively shifted by 790 and 390 mV as compared to bare SS316L and PANI-SS316L, respectively. The corresponding potentiostatic corrosion current density of AuNP-PANI was reduced to 0.63 μA/cm<sup>2</sup> from 2.28 and 0.65 μA/cm<sup>2</sup> for bare SS316L and PANI-SS316L samples, respectively, thereby providing excellent stability in the cathodic polymer electrolyte fuel cell (PEFC) environment. Extensive electron microscopy and X-ray diffraction studies showed uniformly placed AuNP bundles with an average cluster size of 16 nm with Au (200) as the most prominent crystallite phase. Thermogravimetric studies revealed that the AuNPs did not affect the thermal stability of PANI which remained stable up to 260 °C which is well above the operating temperature of conventional PEFCs, making them highly suitable for coatings on bipolar plates for enhanced conductivity and corrosion resistance

    Legislative Documents

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    Also, variously referred to as: Senate bills; Senate documents; Senate legislative documents; legislative documents; and General Court documents

    Direct Wet-Spun Single-Walled Carbon Nanotubes-Based <i>p–n</i> Segmented Filaments toward Wearable Thermoelectric Textiles

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    Three-dimensional thermoelectric (TE) textiles (TETs) fabricated with TE filaments (TEFs) possess merits over other types such as thickness–direction thermal energy harvesting and excellent conformability with dynamic body curves, revealing the prospect of generating electricity for on-body application. Nonetheless, there is still a lack of a costless but scalable method to automatically and seamlessly produce in-series interconnected p–n segmented TEFs with high TE properties via conventional fiber spinning processes. Here, we developed an alternate wet-spinning strategy to continuously manufacture single-walled carbon nanotube-based p–n segmented TEFs at large scale. The TEF with high electrical conductivity (400–800 S cm–1) displays a low contact resistivity of 189.8 μΩ cm2 between the segments and interelectrode, showing 2 orders of magnitude smaller than that reported in the literature. More importantly, the power factors of p-type and n-type segments are 26.25 and 17.14 μW m–1 K–2, respectively, which are 3 and 4 orders of magnitude higher than those of advanced studies. We finally embroidered it into spacer fabric to fabricate a wearable TET, demonstrating an output power density of 501 nW m–2 at ΔT = 27.7 K. The methodology can inspire the development of fiber-based electronics such as wearable TEs and diodes and so forth

    Direct Wet-Spun Single-Walled Carbon Nanotubes-Based <i>p–n</i> Segmented Filaments toward Wearable Thermoelectric Textiles

    No full text
    Three-dimensional thermoelectric (TE) textiles (TETs) fabricated with TE filaments (TEFs) possess merits over other types such as thickness–direction thermal energy harvesting and excellent conformability with dynamic body curves, revealing the prospect of generating electricity for on-body application. Nonetheless, there is still a lack of a costless but scalable method to automatically and seamlessly produce in-series interconnected p–n segmented TEFs with high TE properties via conventional fiber spinning processes. Here, we developed an alternate wet-spinning strategy to continuously manufacture single-walled carbon nanotube-based p–n segmented TEFs at large scale. The TEF with high electrical conductivity (400–800 S cm–1) displays a low contact resistivity of 189.8 μΩ cm2 between the segments and interelectrode, showing 2 orders of magnitude smaller than that reported in the literature. More importantly, the power factors of p-type and n-type segments are 26.25 and 17.14 μW m–1 K–2, respectively, which are 3 and 4 orders of magnitude higher than those of advanced studies. We finally embroidered it into spacer fabric to fabricate a wearable TET, demonstrating an output power density of 501 nW m–2 at ΔT = 27.7 K. The methodology can inspire the development of fiber-based electronics such as wearable TEs and diodes and so forth

    DataSheet1_Comparative efficacy and safety of Chinese medicine injections combined with capecitabine and oxaliplatin chemotherapies in treatment of colorectal cancer: A bayesian network meta-analysis.PDF

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    Objective: The aim of the present Bayesian network meta-analysis (NMA) was to explore the comparative effectiveness and safeaty of different Chinese Medicine injections (CMIs) combined with the XELOX regimen versus XELOX alone for colorectal cancer (CRC).Methods: A comprehensive search for randomized controlled trials (RCTs) was performed with regard to different CMIs for the treatment of CRC in several electronic databases up to April 2022. The quality assessment of the included RCTs was conducted according to the Cochrane risk of bias tool. Standard pair-wise and Bayesian NMA were designed to comparethe effectiveness and safety of different CMIs combined with the XELOX regimen by utilizing R 4.0.3 software and Stata 15.1 software simultaneously.Results: Initially, a total of 4296 citations were retrieved through comprehensive searching, and 32 eligible articles involving 2847 participants and 11 CMIs were ultimately included. CMIs combined with XELOX were superior to the XELOX regimen alone, and a total of ten Observation Indicators were included in the study, with the following results. Among all the injections, Shengmaiyin, Shenmai, and Kanglaite combined with the XELOX regimen were the three CMIs with the highest clinical efficiency. The top three in terms of improving CD3+ values were Shengmaiyin, Shenqifuzheng, and Cinobufacini injections. Shenqifuzheng, Shengmaiyin, and BruceaJavanica oil injections combined with the XELOX regimen performed best at raising CD4+ values. Kanglaite, Cinobufacini, and Matrine injections combined with the XELOX regimen performed best in improving CD4+/CD8+ rates. The top three in terms of improving performance status were Xiaoaiping, Shenmai, and Kanglaite injections. Cinobufacini and Brucea Javanica oil injections combined with the XELOX regimen performed best at raising CD8+ values. Shenqifuzheng, Kangai, and Matrine injections combined with the XELOX regimen performed best in improving Gastrointestinal reactions.The top threein terms of improving Leukopenia were Shenqifuzheng, Compound Kushen and Kanglaite injections. The top three in terms of improving Platelet decline were Compound Kushen, Cinobufacini and Shenqifuzheng injections. Additionally, those that were best at improving nausea and vomitting were Cinobufacini, Compound Kushen and Aidi injections.Conclusion: The results of the analysis demonstrated thatShengmaiyin, Kanglaite, and Cinobufacini injections and the XELOX regimen were associated with morepreferable and beneficial outcomes than other CMI groups. Nevertheless, additional results from multicenter trials and high-quality studies will bevital to support our findings.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=326097, CRD42022326097.</p

    Additional file 8: of Transferring knowledge of bacterial protein interaction networks to predict pathogen targeted human genes and immune signaling pathways: a case study on M. tuberculosis

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    Text file contains the gene ontology analysis of the validated less significant interlogs that get involved in drug resistance of target-modifying enzymes. (TXT 21 kb

    Exploring the Mechanisms of Differentiation, Dedifferentiation, Reprogramming and Transdifferentiation

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    <div><p>We explored the underlying mechanisms of differentiation, dedifferentiation, reprogramming and transdifferentiation (cell type switchings) from landscape and flux perspectives. Lineage reprogramming is a new regenerative method to convert a matured cell into another cell including direct transdifferentiation without undergoing a pluripotent cell state and indirect transdifferentiation with an initial dedifferentiation-reversion (reprogramming) to a pluripotent cell state. Each cell type is quantified by a distinct valley on the potential landscape with higher probability. We investigated three driving forces for cell fate decision making: stochastic fluctuations, gene regulation and induction, which can lead to cell type switchings. We showed that under the driving forces the direct transdifferentiation process proceeds from a differentiated cell valley to another differentiated cell valley through either a distinct stable intermediate state or a certain series of unstable indeterminate states. The dedifferentiation process proceeds through a pluripotent cell state. Barrier height and the corresponding escape time from the valley on the landscape can be used to quantify the stability and efficiency of cell type switchings. We also uncovered the mechanisms of the underlying processes by quantifying the dominant biological paths of cell type switchings on the potential landscape. The dynamics of cell type switchings are determined by both landscape gradient and flux. The flux can lead to the deviations of the dominant biological paths for cell type switchings from the naively expected landscape gradient path. As a result, the corresponding dominant paths of cell type switchings are irreversible. We also classified the mechanisms of cell fate development from our landscape theory: super-critical pitchfork bifurcation, sub-critical pitchfork bifurcation, sub-critical pitchfork with two saddle-node bifurcation, and saddle-node bifurcation. Our model showed good agreements with the experiments. It provides a general framework to explore the mechanisms of differentiation, dedifferentiation, reprogramming and transdifferentiation.</p></div

    Additional file 7: of Transferring knowledge of bacterial protein interaction networks to predict pathogen targeted human genes and immune signaling pathways: a case study on M. tuberculosis

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    Text file contains the gene ontology analysis of the validated less significant interlogs that get involved in drug resistance of antibiotic efflux pumps. (TXT 234 kb

    Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction

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    <div><p>Interferon regulatory factor 8 (IRF8), also known as interferon consensus sequence-binding protein (ICSBP), is a transcription factor of the IRF family. IRF8 plays a key role in normal B cell differentiation, a cellular process that is intrinsically associated with Epstein-Barr virus (EBV) reactivation. However, whether IRF8 regulates EBV lytic replication remains unknown. In this study, we utilized a CRISPR/Cas9 genomic editing approach to deplete <i>IRF8</i> and found that <i>IRF8</i> depletion dramatically inhibits the reactivation of EBV upon lytic induction. We demonstrated that <i>IRF8</i> depletion suppresses the expression of a group of genes involved in apoptosis and thus inhibits apoptosis induction upon lytic induction by B cell receptor (BCR) stimulation or chemical induction. The protein levels of caspase-1, caspase-3 and caspase-8 all dramatically decreased in <i>IRF8</i>-depleted cells, which led to reduced caspase activation and the stabilization of KAP1, PAX5 and DNMT3A upon BCR stimulation. Interestingly, caspase inhibition blocked the degradation of KAP1, PAX5 and DNMT3A, suppressed EBV lytic gene expression and viral DNA replication upon lytic induction, suggesting that the reduced caspase expression in <i>IRF8</i>-depleted cells contributes to the suppression of EBV lytic replication. We further demonstrated that IRF8 directly regulates <i>CASP1 (caspase-1)</i> gene expression through targeting its gene promoter and knockdown of caspase-1 abrogates EBV reactivation upon lytic induction, partially through the stabilization of KAP1. Together our study suggested that, by modulating the activation of caspases and the subsequent cleavage of KAP1 upon lytic induction, IRF8 plays a critical role in EBV lytic reactivation.</p></div

    The phase diagram, barrier height, probability of the dominant path and mean first passaging time for different mutual repression strength .

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    <p>A: The phase diagram for changing mutual repression strength with . B: The barrier heights versus the parameter . C: The probability of the dominant path through the progenitor cell state divided that of the path through the intermediate state versus the inhibition strength . D: The mean first passaging time through the two paths versus the inhibition strength .</p
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