48 research outputs found

    Perfect difference systems of sets and Jacobi sums

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    AbstractA perfect (v,{ki∣1≤i≤s},ρ) difference system of sets (DSS) is a collection of s disjoint ki-subsets Di, 1≤i≤s, of any finite abelian group G of order v such that every non-identity element of G appears exactly ρ times in the multiset {a−b∣a∈Di,b∈Dj,1≤i≠j≤s}. In this paper, we give a necessary and sufficient condition in terms of Jacobi sums for a collection {Di∣1≤i≤s} defined in a finite field Fq of order q=ef+1 to be a perfect (q,{ki∣1≤i≤s},ρ)-DSS, where each Di is a union of cyclotomic cosets of index e (and the zero 0∈Fq). Also, we give numerical results for the cases e=2,3, and 4

    A case with difficulty in airway management nevertheless switching from emergency tracheostomy to cricothyrotomy

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    深頸部膿瘍は時に急速な喉頭浮腫を来たし窒息に至ることもある救急疾患である.深夜に救急外来を受診し手術室にて気道確保中に窒息をきたし,院内コードブルー発動を経て救命し得た深頸部膿瘍の1例を経験したので報告する.症例は60代男性.増悪する咽頭痛,軽度の呼吸苦を主訴に当院へ救急搬送された来院後より次第に呼吸苦が増悪し,甲状軟骨内側の膿瘍および高度の喉頭浮腫を認め,気管切開による気道確保を計画した.術中,窒息が切迫した状態となり迅速に気道を確保するために輪状甲状膜切開に術式を切り替えた.しかし,呼吸苦から体動が多く不穏となりまた体動・出血に伴い窒息に至り,徐々に血中酸素飽和度が低下していった通常の手術続行が不可能となった段階で院内コードブルーを要請し,人員を集め,輪状甲状間膜切開・気道確保に成功した最終的には後遺症なく救命が可能であった

    Peripheral Blood as a Preferable Source of Stem Cells for Salvage Transplantation in Patients with Graft Failure after Cord Blood Transplantation: A Retrospective Analysis of the Registry Data of the Japanese Society for Hematopoietic Cell Transplantation

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    To compare the different stem cell sources used in salvage transplantation for graft failure (GF) after cord blood transplantation (CBT), we retrospectively analyzed data of 220 patients who developed GF after undergoing CBT between January 2001 and December 2007 and underwent a second hematopoietic stem cell transplantation (HSCT) within 3 months. The donor sources for salvage HSCT were cord blood (n = 180), peripheral blood stem cells (PBSCs; n = 24), and bone marrow (BM; n = 16). The cumulative incidence of neutrophil engraftment on day 30 after the second HSCT was 39% with CB, 71% with PBSCs, and 75% with BM. Multivariate analysis revealed that PBSC and BM grafts were associated with a significantly higher engraftment rate than CB (hazard ratio [HR], 7.77; P < .001 and HR, 2.81; P = .016, respectively). Although the incidence of grade II-IV acute graft-versus-host disease was significantly higher in the PBSC group than in the CB group (HR, 2.83; P = .011), the incidence of 1-year nonrelapse mortality was lower in the PBSC group than in the CB group (HR, 0.43; P = .019), and 1-year overall survival was superior in the PBSC group compared with the CB group (HR, 0.45; P = .036). Our results suggest that PBSC is the preferable source of stem cells in salvage HSCT for GF after CBT

    AHCC Activation and Selection of Human Lymphocytes via Genotypic and Phenotypic Changes to an Adherent Cell Type: A Possible Novel Mechanism of T Cell Activation

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    Active Hexose Correlated Compound (AHCC) is a fermented mushroom extract and immune supplement that has been used to treat a wide range of health conditions. It helps in augmentation of the natural immune response and affects immune cell activation and outcomes. The goal of this project was to study and understand the role and mechanisms of AHCC supplementation in the prevention of immunosuppression through T cell activation. The method described here involves “in vitro” culturing of lymphocytes, exposing them to different concentrations of AHCC (0 μg/mL, 50 μg/mL, 100 μg/mL, 250 μg/mL, and 500 μg/mL) at 0 hours. Interestingly, clumping and aggregation of the cells were seen between 24 and 72 hours of incubation. The cells lay down extracellular matrix, which become adherent, and phenotypical changes from small rounded lymphocytes to large macrophage-like, spindle shaped, elongated, fibroblast-like cells even beyond 360 hours were observed. These are probably translated from genotypic changes in the cells since the cells propagate for at least 3 to 6 generations (present observations). RNA isolated was subjected to gene array analysis. We hypothesize that cell adhesion is an activation and survival pathway in lymphocytes and this could be the mechanism of AHCC activation in human lymphocytes

    Reference values for the locomotive syndrome risk test quantifying mobility of 8681 adults aged 20–89 years: A cross-sectional nationwide study in Japan

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    Background The locomotive syndrome risk test was developed to quantify the decrease in mobility among adults, which could eventually lead to disability. The purpose of this study was to establish reference values for the locomotive syndrome risk test for adults and investigate the influence of age and sex. Methods We analyzed 8681 independent community dwellers (3607 men, 5074 women). Data pertaining to locomotive syndrome risk test (the two-step test, the stand-up test, and the 25-question geriatric locomotive function scale [GLFS-25]) scores were collected from seven administrative areas of Japan. Results The reference values of the three test scores were generated and all three test scores gradually decreased among young-to-middle-aged individuals and rapidly decreased in individuals aged over 60 years. The stand-up test score began decreasing significantly from the age of 30 years. The trajectories of decrease in the two-step test score with age was slightly different between men and women especially among the middle-aged individuals. The two physical test scores were more sensitive to aging than the self-reported test score. Conclusion The reference values generated in this study could be employed to determine whether an individual has mobility comparable to independent community dwellers of the same age and sex

    アルデヒド オ カルボニルゲン ト スル ショクバイテキ カルボニルカホウ ノ カイハツ

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    https://library.naist.jp/mylimedio/dllimedio/show.cgi?bookid=100045275&oldid=84004博士 (Doctor)理学 (Science)博第503号甲第503号博士(理学)奈良先端科学技術大学院大
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