169 research outputs found

    Managing uncertainty: how risk assessment can empower field research

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    The discussion on risk in social science fieldwork has seen two diametrically opposed positions. On the one hand, there are those who advocate risk avoidance. Frequently driven by concerns about legal exposure and insurance coverage, such perspectives tend to predominate in university administrations and among funding bodies. They consequently also shape the risk assessment procedures many research projects must clear. Their main aim is to minimize risk by avoiding risky research topics and field sites altogether. Taken to its logical conclusion, however, such a position would endanger knowledge production on issues of central social and political importance

    Illinois State University Faculty Jazz Ensemble

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    Center for the Performing Arts Tuesday Evening March 4, 2008 8:00p.m

    ISU Faculty Jazz Ensemble

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    Kemp Recital Hall March 20, 2019 Wednesday Evening 8:00p.m

    Faculty Jazz Recital

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    University GalleriesJanuary 31, 2013Thursday Evening8:00 p.m

    Faculty Ensemble: Faculty Jazz

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    University GalleriesOctober 29, 2012Tuesday Evening8:00 p.m

    Faculty Recital: ISU Faculty Jazz Ensemble

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    Kemp Recital Hall October 23, 2018 Tuesday Evening 8:00p.m

    Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids

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    Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear. We combined the use of stem cell-derived inner ear organoids with single-cell RNA sequencing to investigate the role of TMPRSS3. Defective Tmprss3 leads to hair cell apoptosis without altering the development of hair cells and the formation of the mechanotransduction apparatus. Prior to degeneration, Tmprss3-KO hair cells demonstrate reduced numbers of BK channels and lower expressions of genes encoding calcium ion-binding proteins, suggesting a disruption in intracellular homeostasis. A proteolytically active TMPRSS3 was detected on cell membranes in addition to ER of cells in inner ear organoids. Our in vitro model recapitulated salient features of genetically associated inner ear abnormalities and will serve as a powerful tool for studying inner ear disorders
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