3,708 research outputs found

    Observation of coasting beam at the HERA Proton--Ring

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    We present data collected with the HERA-B wire target which prove the existence of coasting beam at the HERA proton storage ring. The coasting beam is inherently produced by the proton machine operation and is not dominated by target effects.Comment: 17 pages (Latex), 12 figures (Enc. Postscript

    The Development of a Well-Being Program for Occupational Therapy Graduate Students

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    High levels of stress among occupational therapy graduate students have led to the adoption of unhealthy coping habits such as poor nutrition, little exercise, and disrupted sleep. In response, many institutions have explored programming and even curricular changes to support student well-being. However, very few are built upon a strong theoretical foundation to address holistic well-being. Therefore, this paper describes how logic modeling was used to develop a student well-being program based on Facilitating Learning and Occupational Well-Being Using Research-Based Initiatives for Student Health (FLOURISH), a theoretical approach rooted in the Person-Environment-Occupation Performance Model. A well-being program delivered via a virtual community of practice for entry-level students at a Midwestern occupational therapy program was created to decrease stress and enhance overall well-being for the performance of learning. The program consisted of eight 50-minute sessions that met once per week and included topics of physical, mental, sociocultural, environmental, and occupational well-being. The student well-being program is one viable option that shows promise to empower students with a theoretical approach to address personal and professional well-being, which has the potential to translate into professional practice. In this article, we describe the well-being program and the theoretical approach in detail and illustrate how it can be used to improve occupational therapy student well-being

    Prospects for the Search for a Standard Model Higgs Boson in ATLAS using Vector Boson Fusion

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    The potential for the discovery of a Standard Model Higgs boson in the mass range m_H < 2 m_Z in the vector boson fusion mode has been studied for the ATLAS experiment at the LHC. The characteristic signatures of additional jets in the forward regions of the detector and of low jet activity in the central region allow for an efficient background rejection. Analyses for the H -> WW and H -> tau tau decay modes have been performed using a realistic simulation of the expected detector performance. The results obtained demonstrate the large discovery potential in the H -> WW decay channel and the sensitivity to Higgs boson decays into tau-pairs in the low-mass region around 120 GeV.Comment: 20 pages, 13 ps figures, uses EPJ style fil

    A High Luminosity e+e- Collider to study the Higgs Boson

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    A strong candidate for the Standard Model Scalar boson, H(126), has been discovered by the Large Hadron Collider (LHC) experiments. In order to study this fundamental particle with unprecedented precision, and to perform precision tests of the closure of the Standard Model, we investigate the possibilities offered by An e+e- storage ring collider. We use a design inspired by the B-factories, taking into account the performance achieved at LEP2, and imposing a synchrotron radiation power limit of 100 MW. At the most relevant centre-of-mass energy of 240 GeV, near-constant luminosities of 10^34 cm^{-2}s^{-1} are possible in up to four collision points for a ring of 27km circumference. The achievable luminosity increases with the bending radius, and for 80km circumference, a luminosity of 5 10^34 cm^{-2}s^{-1} in four collision points appears feasible. Beamstrahlung becomes relevant at these high luminosities, leading to a design requirement of large momentum acceptance both in the accelerating system and in the optics. The larger machine could reach the top quark threshold, would yield luminosities per interaction point of 10^36 cm^{-2}s^{-1} at the Z pole (91 GeV) and 2 10^35 cm^{-2}s^{-1} at the W pair production threshold (80 GeV per beam). The energy spread is reduced in the larger ring with respect to what is was at LEP, giving confidence that beam polarization for energy calibration purposes should be available up to the W pair threshold. The capabilities in term of physics performance are outlined.Comment: Submitted to the European Strategy Preparatory Group 01-04-2013 new version as re-submitted to PRSTA

    Machine Learning Analyses of Highly-Multiplexed Immunofluorescence Identifies Distinct Tumor and Stromal Cell Populations in Primary Pancreatic Tumors

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    BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a formidable challenge for patients and clinicians. OBJECTIVE: To analyze the distribution of 31 different markers in tumor and stromal portions of the tumor microenvironment (TME) and identify immune cell populations to better understand how neoplastic, non-malignant structural, and immune cells, diversify the TME and influence PDAC progression. METHODS: Whole slide imaging (WSI) and cyclic multiplexed-immunofluorescence (MxIF) was used to collect 31 different markers over the course of nine distinctive imaging series of human PDAC samples. Image registration and machine learning algorithms were developed to largely automate an imaging analysis pipeline identifying distinct cell types in the TME. RESULTS: A random forest algorithm accurately predicted tumor and stromal-rich areas with 87% accuracy using 31 markers and 77% accuracy using only five markers. Top tumor-predictive markers guided downstream analyses to identify immune populations effectively invading into the tumor, including dendritic cells, CD4+ T cells, and multiple immunoregulatory subtypes. CONCLUSIONS: Immunoprofiling of PDAC to identify differential distribution of immune cells in the TME is critical for understanding disease progression, response and/or resistance to treatment, and the development of new treatment strategies
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