1,444 research outputs found

    The Relationship Between Leisure Traveler\u27s hotel Attribute Satisfaction and Overall Satisfaction

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    Manystudies have been conducted about hotel attributesrelated tothehotel choice decision as a part ofacustomer’s pre- purchase behavior(Dolnicar&Otter, 2003). Althoughit iscritical for hotel managerstounderstand post-trip behavior because such behaviorsmaydirectlyinfluence their futurebehavior, therearefew researchstudieswhich examine hotel attributesrelated to acustomer’spost-trip behavior.This studyteststhe relationship between leisure traveler’shotel attribute satisfaction and overall satisfaction in the post-trip behaviorperspectiveina hotel setting andexaminestherelative impactofhotel attributesatisfaction in influencing overall satisfaction. Multiple regressionwas used totestthe relationship and hotel attribute satisfaction isan important antecedent tooverall satisfaction. Theoretical and practical implications ofthe studyare discussed

    The Relationship between Leisure Traveler’s Hotel Attribute Satisfaction and Overall Satisfaction

    Get PDF
    Manystudies have been conducted about hotel attributesrelated tothehotel choice decision as a part ofacustomer’s pre- purchase behavior(Dolnicar&Otter, 2003). Althoughit iscritical for hotel managerstounderstand post-trip behavior because such behaviorsmaydirectlyinfluence their futurebehavior, therearefew researchstudieswhich examine hotel attributesrelated to acustomer’spost-trip behavior.This studyteststhe relationship between leisure traveler’shotel attribute satisfaction and overall satisfaction in the post-trip behaviorperspectiveina hotel setting andexaminestherelative impactofhotel attributesatisfaction in influencing overall satisfaction. Multiple regressionwas used totestthe relationship and hotel attribute satisfaction isan important antecedent tooverall satisfaction. Theoretical and practical implications ofthe studyare discussed

    Guest Delight: The Influence of Sustainable Performance and Guests\u27 Perceived Health and Safety

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    Recently, the COVID-19 pandemic has further emphasized the importance of guests’ health, safety, and well-being in the hotel industry. Further, in today’s highly competitive environment, hotels must orchestrate memorable experiences for guests to realize their value and become ambassadors for the brand. The purpose of this research is to explore the antecedents (i.e., sustainable performance, safety, and health) and the outcomes (i.e., brand love, trust, and willingness to pay more) of customer delight. Surveys will be distributed to hotel guests and the results can provide insights and implications for scholars and practitioners to better understand the concept of customer delight

    Clinical and microbiologic characteristics of tcdA-negative variant clostridium difficile infections

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    BACKGROUND: The tcdA-negative variant (A(-)B(+)) of Clostridium difficile is prevalent in East Asian countries. However, the risk factors and clinical characteristics of A(-)B(+)C. difficile infections (CDI) are not clearly documented. The objective of this study was to investigate these characteristics. METHODS: From September 2008 through January 2010, the clinical characteristics, medication history and treatment outcomes of CDI patients were recorded prospectively. Toxin characterization and antibiotic susceptibility tests were performed on stool isolates of C. difficile. RESULTS: During the study period, we identified 22 cases of CDI caused by tcdA-negative tcdB-positive (A(-)B(+)) strains and 105 cases caused by tcdA-positive tcdB-positive (A(+)B(+)) strains. There was no significant difference in disease severity or clinical characteristics between the two groups. Previous use of clindamycin and young age were identified as significant risk factors for the acquisition of A(-)B(+) CDI (OR = 4.738, 95% CI 1.48–15.157, p = 0.009 and OR = 0.966, 95% CI 0.935–0.998, p = 0.038, respectively) in logistic regression. Rates of resistance to clindamycin were 100% and 69.6% in the A(-)B(+) and A(+)B(+) isolates, respectively (p = 0.006), and the ermB gene was identified in 17 of 21 A(-)B(+) isolates (81%). Resistance to moxifloxacin was also more frequent in the A(-)B(+) than in the A(+)B(+) isolates (95.2% vs. 63.7%, p = 0.004). CONCLUSIONS: The clinical course of A(-)B(+) CDI is not different from that of A(+)B(+) CDI. Clindamycin use is a significant risk factor for the acquisition of tcdA-negative variant strains

    One-Step Synthesis of Pd-M/ZnO (M=Ag, Cu, and Ni) Catalysts by γ

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    ZnO-supported Pd, Pd-Ag, Pd-Cu, and Pd-Ni catalysts (Pd-M/ZnO) were prepared in MeOH/H2O mixture (4/1, v/v-%) by γ-irradiation at room temperature. Small mono- and bimetallic nanoparticles were loaded on the surface of ZnO nanopowder as confirmed with TEM, TEM-EDXS, XRD, and ICP-AES data. The catalytic efficiency against Pd-M/ZnO was determined in hydrogenation and Suzuki reaction and compared with the commercial Pd/C catalyst. The Pd-Ag/ZnO showed the highest catalytic efficiency in the Suzuki reaction

    Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT

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    Telomere homeostasis is regulated by telomerase and a collection of associatedproteins. Telomerase is, in turn, regulated by post-translational modifications of the rate-limiting catalytic subunit hTERT. Here we show that disruption of Hsp90 by geldanamycin promotes efficient ubiquitination and proteasome-mediated degradation of hTERT. Furthermore, we have used the yeast two-hybrid method to identify a novel RING finger gene (MKRN1) encoding an E3 ligase that mediates ubiquitination of hTERT. Overexpression of MKRN1 in telomerase-positive cells promotes the degradation of hTERT and decreases telomerase activity and subsequently telomere length. Our data suggest that MKRN1 plays an important role in modulating telomere length homeostasis through a dynamic balance involving hTERT protein stability

    Visfatin exerts angiogenic effects on human umbilical vein endothelial cells through the mTOR signaling pathway

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    AbstractThe biologically active factors known as adipocytokines are secreted primarily by adipose tissues and can act as modulators of angiogenesis. Visfatin, an adipocytokine that has recently been reported to have angiogenic properties, is upregulated in diabetes, cancer, and inflammatory diseases. Because maintenance of an angiogenic balance is critically important in the management of these diseases, understanding the molecular mechanism by which visfatin promotes angiogenesis is very important. In this report, we describe our findings demonstrating that visfatin stimulates the mammalian target of the rapamycin (mTOR) pathway, which plays important roles in angiogenesis. Visfatin induced the expression of hypoxia-inducible factor 1α (HIF1α) and vascular endothelial growth factor (VEGF) in human endothelial cells. Inhibition of the mTOR pathway by rapamycin eliminated the angiogenic and proliferative effects of visfatin. The visfatin-induced increase in VEGF expression was also eliminated by RNA interference-mediated knockdown of the 70-kDa ribosomal protein S6 kinase (p70S6K), a downstream target of mTOR. Visfatin inactivated glycogen synthase kinase 3β (GSK3β) by phosphorylating it at Ser-9, leading to the nuclear translocation of β-catenin. Both rapamycin co-treatment and p70S6K knockdown inhibited visfatin-induced GSK3β phosphorylation at Ser-9 and nuclear translocation of β-catenin. Taken together, these results indicate that mTOR signaling is involved in visfatin-induced angiogenesis, and that this signaling leads to visfatin-induced VEGF expression and nuclear translocation of β-catenin
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