187 research outputs found

    Land Grant Application- Kilburn, John (Sterling)

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    Land grant application submitted to the Maine Land Office for John Kilburn for service in the Revolutionary War.https://digitalmaine.com/revolutionary_war_mass/1212/thumbnail.jp

    Security and Rational Choice: Household, Community, and Public Provision.

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    This dissertation examines the problem of order through an analysis of individual practices of security. Because security is a multi-dimensional issue, no unified perspective currently exists to explain security practices. Based on my analysis of data from a detailed survey of 137 residents of a Baton Rouge neighborhood, I argue that there are three main dimensions of security and each has a unique set of determinants, since individuals are contextually situated in their households, neighborhoods, and municipalities. This dissertation examines variables related to psychological, stratification, social network, and rational choice perspectives. The analysis demonstrates that although factors suggested by each of these perspectives contribute to an explanation of security, no one factor explains security-related behaviors at all levels. I argue that citizens vary in the types of actions they take to provide security because of differential levels of trust in different agents to provide necessary services. Some trust their own abilities to provide security for themselves, some trust neighborhood programs, and some trust the government to provide security. Because trust is a key issue in understanding security, I propose that future research on security acknowledge the importance of trust. I suggest that part of the failure of the rational choice perspective to present a unified explanation of security is that it does not properly understand self interest. The rational choice perspective should acknowledge the relationship between trust and security, and trust and order. Fear of crime is significantly related to individuals\u27 personal avoidance measures. Association with neighbors is related to taking fewer protective measures in and around the home. Knowledge of others in the neighborhood has an inverse relationship with the number of protective measures taken. I offer no explanation of support for contributions to the community crime-prevention organization. Trust in local government, educational attainment, and tax liability explains support for the tax millages

    Collective private urban renewal in New Bedford's historic district

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    Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning; and, (M. Arch.)--Massachusetts Institute of Technology, Dept. of Architecture, 1974.Includes bibliograpical references (leaves 72-74).This thesis examines the waterfront historic district in New Bedford, Massachusetts. It is, hopefully, the beginning of a process of collective private renewal that may lead the revival of the district as a vital element in the city's recovery. It describes the problems and some of the potential of an effort by an organized group of citizens to renew their community - an alternative to renewal by the government or by large developers. Two themes run throughout the thesis. The first is the city itself: how any attempt at planning for the district must acknowledge its relationship to the city. The second is the role the "professional" plays. This thesis is the work of a "location-oriented change-maker," a person whose first allegiance is to a location and its problems and secondly to a profession that might be involved in solutions to the problems. The thesis begins with a history of the district, which was the city in the days of whaling. It then discusses the problems that face the people of New Bedford today and the plans the city has for her future. The second part of the thesis is a description of the historic district and its people and concludes with a discussion of what it might become and how. Physical implications are included in the appendix.by John K. Bullard.M.Arch.M.C.P

    Flamingo Vol. III N 2

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    Anonymous. Cover. Picture. 0. Anonymous. Untitled. Picture. 4. Price, John M. Dada--Esthetic Nihilism. Prose. 5. G.C. Tolerance. Poem. 6. G.W.B. The Castaway. Poem. 6. G.W.B. Cinquains. Poem. 7. Holt, K. HORATI CARMINA, Liber I, ix. Prose. 7. W.A.V. Untitled. Poem. 7. A.E.R. Moods. Poem. 7. G.W.B. Some Say The Moon. Poem. 7. A.E.R. On Quoting The Night Has A Thousand Eyes . Poem. 7. Anonymous. Chapel Cherubs. Prose. 8. E.B. Untitled. Picture. 8. E.B. Untitled. Picture. 8. Anonymous. Untitled. Prose. 9. Anonymous. Untitled. Prose. 9. Anonymous. FLIP— MIGHT I ASK YOU FOR THIS DANCE? FLAP— PLEASE DO, I\u27VE BEEN DYING TO REFUSE YOU ALL EVENING. . Picture. 9. Anonymous. HUSBAND (SAVAGELY)— MARIA, WHERE\u27S MY CLOTHES? MARIA— GOOD HEAVENS, DEAR, I WONDER IF I USED THEM IN THE SALAD. Picture. 9. Anonymous. Our Log Table. Prose. 9. Anonymous. Approved Vocabulary For Fans. Prose. 9. Anonymous. Untitled. Prose. 9.; Anonymous. Untitled. Prose. 9. Anonymous. Untitled. Prose. 9. Anonymous. Untitled. Prose. 9. Anonymous. Only Too True! Prose. 10. F.T. GEORGE TOLD ME ALL THE SECRETS OF HIS PAST LAST NIGHT. REALLY! WHAT DID YOU THINK OF THEM? OH, I THOUGHT THEY WERE HORRIBLY DISAPPOINTING. Picture. 10. Anonymous. Untitled. Prose. 10. Anonymous. Untitled. Prose. 10. Anonymous. Untitled. Prose. 10. Howard, Lillis. The Engaged Homo. Poem. 10. Anonymous. Before and After. Poem. 11. Anonymous. Untitled. Poem. 11. Ubersax. AS OTHERS MIGHT SEE US—CLEVELAND HALL TO A CUBIST. Picture. 11. Anonymous. Untitled. Prose. 11. Anonymous. Untitled. Prose. 11. Anonymous. Untitled. Prose. 11. Anonymous. SECOND FROM THE RIGHT— WHAT\u27S THAT DESERTED OLD BUILDING OVER THERE? DITTO LEFT— MUST BE WHERE THEY USED TO MAKE HAIRPINS. Picture. 11. Anonymous. Untitled. Prose. 11. Anonymous. Untitled. Prose. 11. E.T.B. Broadway Bizarre. Prose. 12. E.B. Untitled. Picture. 13. E.B. The First One. Picture. 13. Anonymous. It\u27s done. Prose. 14. W.G.M. Mother. Prose. 15. Anonymous. Our Daily Mud. Prose. 15. G.C. Optimism. Poem. 15. Bridge. Denison Comics. Picture. 16. Anonymous. Our Asinetic Appreciation Corner. Prose. 18. Anonymous. STILL LIFE OF A NEAR-BEER AT THE TURNING POINT. Picture. 18. Rine, Russell. Stewed and Hashed. Poem. 18. Anonymous. Untitled. Poem. 18. Anonymous. Untitled. Poem. 19. Anonymous. Untitled. Prose. 19. Anonymous. Untitled. Prose. 19. Mercer, Hod. OUR OWN IDEA OF SOMETHING AESTHETIC. Picture. 19. Anonymous. Untitled. Prose. 19. Anonymous. Untitled. Prose. 19. Anonymous. Such Is Life. Poem. 19. Anonymous. Untitled. Prose. 19. Anonymous. Untitled. Prose. 19. Grayce. THE FLIGHT IS ON—THE FESTIVAL IS HERE. Picture. 20. W.G.K. Eutopia Regained. Prose. 20. Anonymous. Untitled. Prose. 20. Anonymous. Untitled. Prose. 20. Anonymous. Oh You Nine Weeks. Poem. 20. Anonymous. Untitled. Prose. 20. Anonymous. Untitled. Prose. 20. Anonymous. Untitled. Prose. 20. Anonymous. THAT MAUSOLEUM HAS BEEN CONDEMNED BY THE BUILDING INSPECTOR. WHAT\u27S WRONG WITH IT? IT HASN\u27T ANY FIRE ESCAPES. Picture. 20. Jester. Untitled. Prose. 24. Anonymous. Untitled. Prose. 24. Panther. Untitled. Prose. 24. Octopus. Untitled. Prose. 24. Mugwump. Untitled. Prose. 24. Reel, Virginia. Untitled. Prose. 24. Garber, Jock. Kows and Why Not. Prose. 25. Texas Scalper. Untitled. Prose. 25. Lord Jeff. Untitled. Prose. 28. Lampoon. Cut Rates. Prose. 28. Malteaser. Untitled. Prose. 28. Sun Dodger. Untitled. Prose. 28. Beanpot. Untitled. Prose. 28. Malteaser. Untitled. Prose. 28. Gargoyle. Putting It Fairly. Prose. 29. Malteaser. Untitled. Prose. 29. Gargoyle. Untitled. Prose. 29. Sun Dial. Untitled. Prose. 29. Gargoyle. Untitled. Prose. 30. Malteaser. Untitled. Prose. 30. Panther. Untitled. Prose. 30. Sun Dial. The Stuffed Kind. Prose. 30. Student Life. Untitled. Prose. 30. Malteaser. Heard in EC. Class. Prose. 30. Nashville Tennessean. Untitled. Prose. 30. Lemon Punch. Untitled. Prose. 31. Sun Dial. Untitled. Prose. 31. Gargoyle. Two is a Crowd. Prose. 31. Phoenix. Untitled. Prose. 31

    When Government Is Not the Solution: The Role of Community Organizations in Outreach

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    Trust between government entities and the public is critical; without it, communities become paralyzed in their ability to act collectively and for the greater good. Establishing and maintaining this trust, however, can be difficult. The outreach and coproduction performed by the coalition of organizations described in this article provide examples of how to address several interrelated problems of public distrust in the government. When viewed in their proper light, these examples enrich the theoretical understanding of contract failure theory. Rather than take advantage of their advantages in power, governments increasingly leverage the power of reciprocity to accomplish their goals by relying on preexisting community trust in nonprofits. Self-interest well understood is a critical component of this reciprocal relationship: it works best when government secures resources, funding, and access to policy processes, in return for nonprofit resources such as service delivery, political support, buy-in, and legitimacy. In this indirect way, nonprofit coproduction can help to foster perceptions of legitimacy and trust in government

    An Evaluation of the Sensitivity of Subjects with Peanut Allergy to Very Low Doses of Peanut Protein: A Randomized, Double-Blind, Placebo-Controlled Food Challenge Study

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    The minimum dose of food protein to which subjects with food allergy have reacted in double-blind, placebo-controlled food challenges is between 50 and 100 mg. However, subjects with peanut allergy often report severe reactions after minimal contact with peanuts, even through intact skin. Objective: We sought to determine whether adults previously proven by challenge to be allergic to peanut react to very low doses of peanut protein. Methods: We used a randomized, double-blind, placebo-controlled food challenge of 14 subjects allergic to peanuts with doses of peanut ranging from 10 ÎĽg to 50 mg, administered in the form of a commercially available peanut flour. Results: One subject had a systemic reaction to 5 mg of peanut protein, and two subjects had mild objective reactions to 2 mg and 50 mg of peanut protein, respectively. Five subjects had mild subjective reactions (1 to 5 mg and 4 to 50 mg). All subjects with convincing objective reactions had short-lived subjective reactions to preceding doses, as low as 100 ÎĽg in two cases. Five subjects did not react to any dose up to 50 mg. Conclusion: Even in a group of well-characterized, highly sensitive subjects with peanut allergy, the threshold dose of peanut protein varies. As little as 100 ÎĽg of peanut protein provokes symptoms in some subjects with peanut allergy

    Contrasting microfossil preservation and lake chemistries within the 1200–1000 Ma Torridonian Supergroup of NW Scotland

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    We acknowledge the Australian Microscopy & Microanalysis Research Facility at the Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, a facility funded by the University, State and Commonwealth Governments. DW acknowledges funding from the European Commission and the Australian Research Council. This is publication number 838 from the Australian Research Council Centre of Excellence for Core to Crust Fluid Systems.Publisher PD

    New Tetrahymena basal body protein components identify basal body domain structure

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    Basal bodies organize the nine doublet microtubules found in cilia. Cilia are required for a variety of cellular functions, including motility and sensing stimuli. Understanding this biochemically complex organelle requires an inventory of the molecular components and the contribution each makes to the overall structure. We define a basal body proteome and determine the specific localization of basal body components in the ciliated protozoan Tetrahymena thermophila. Using a biochemical, bioinformatic, and genetic approach, we identify 97 known and candidate basal body proteins. 24 novel T. thermophila basal body proteins were identified, 19 of which were localized to the ultrastructural level, as seen by immunoelectron microscopy. Importantly, we find proteins from several structural domains within the basal body, allowing us to reveal how each component contributes to the overall organization. Thus, we present a high resolution localization map of basal body structure highlighting important new components for future functional studies

    Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003

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    PURPOSE PNOC003 is a multicenter precision medicine trial for children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG). PATIENTS AND METHODS Patients (3-25 years) were enrolled on the basis of imaging consistent with DIPG. Biopsy tissue was collected for whole-exome and mRNA sequencing. After radiotherapy (RT), patients were assigned up to four FDA-approved drugs based on molecular tumor board recommendations. H3K27M-mutant circulating tumor DNA (ctDNA) was longitudinally measured. Tumor tissue and matched primary cell lines were characterized using whole-genome sequencing and DNA methylation profiling. When applicable, results were verified in an independent cohort from the Children's Brain Tumor Network (CBTN). RESULTS Of 38 patients enrolled, 28 patients (median 6 years, 10 females) were reviewed by the molecular tumor board. Of those, 19 followed treatment recommendations. Median overall survival (OS) was 13.1 months [95% confidence interval (CI), 11.2-18.4] with no difference between patients who followed recommendations and those who did not. H3K27M-mutant ctDNA was detected at baseline in 60% of cases tested and associated with response to RT and survival. Eleven cell lines were established, showing 100% fidelity of key somatic driver gene alterations in the primary tumor. In H3K27-altered DIPGs, TP53 mutations were associated with worse OS (TP53mut 11.1 mo; 95% CI, 8.7-14; TP53wt 13.3 mo; 95% CI, 11.8-NA; P = 3.4e-2), genome instability (P = 3.1e-3), and RT resistance (P = 6.4e-4). The CBTN cohort confirmed an association between TP53 mutation status, genome instability, and clinical outcome. CONCLUSIONS Upfront treatment-naĂŻve biopsy provides insight into clinically relevant molecular alterations and prognostic biomarkers for H3K27-altered DIPGs
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