185 research outputs found

    Effect of Educational Program on Outcomes of Patients Undergoing Permanent Pacemakers’ Implantation

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    Contents: Patients undergoing permanent implantable pacemaker, challenge with multiple physical, psychological along with social complications. Teaching patients the essential points involving pacemaker management can prevent complications.Aim: The current study aimed to evaluate the effect of an educational program on outcomes of patients undergoing permanent pacemakers' implantation. Methods: A quasi-experimental pre/posttest and follow-up design were used to conduct this study. A convenient sample of 35 adult patients from both genders undergoing permanent pacemaker implantation was recruited from Beni-Suef University hospital's catheter lab, inpatient department, ICU, CCU, and outpatient cardiology clinic. Patients' interviewing questionnaire, patient performance checklist, pacemaker self-efficacy scale, and Aga Khan University Anxiety and Depression Scale were used to achieve this study's aim. Results: 91.4% of the studied patients had unsatisfactory total knowledge at the baseline, improved to 85.7% had a satisfactory knowledge immediately post educational intervention, and relatively maintained to 68.6% of them had a satisfactory level of total knowledge after four weeks of the program implementation. 97.1% of the studied patients had unsatisfactory total practice at the baseline, improved to 65.7% had a satisfactory practice immediately post educational intervention, and improved to 77.1% of them had a satisfactory level of total practice after four weeks of program implementation. 71.4%, and 85.7% of the studied patients were not confident at all with their ability to control symptoms and maintain their usual functions respectively before education. 91.4% of them reported a total low self-efficacy score before the educational intervention. In comparison, 45.7% were very confident in controlling symptoms and moderately confident in maintaining usual functions at the follow-up phase. Besides, 65.7 exhibited total high self-efficacy at the follow-up assessment. 57.1% of the studied patients exhibit severe anxiety at the baseline assessment, while 65.7% and 74.3% exhibit mild anxiety at the post and follow-up assessment. Conclusion: A statistically significant improvement in patients' knowledge, practice, self-efficacy, anxiety, and depression immediately and after four weeks compared to their baseline. The study recommended that the educational program be an essential part of the total management of patients undergoing implanted pacemakers

    The role of effective governance in determining the relationship between Muslims’ religiosity and their income

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    Most of the studies which examine the effect of religiosity on income in the literature have found the relationship to be negative among Muslims and non-Muslims. The waves of migration of religious Muslims to non-Muslim majority countries have raised concerns about the future of the economic growth of such hosting countries. This paper introduces the government as a variable that interacts with religiosity and explains this complex link. In this study, we use panel data from the World Values Survey and the World Bank Governance Indicators for 68 countries over 14 different years from 1996 to 2014 to test how governance explain the religiosity-income link among Muslims. The study found evidence that countries with higher government effectiveness levels experience a lower negative impact of religiosity on income. Results show that the negative size shrinks with better governance until it becomes statistically insignificant when countries are at a very high government effectiveness level

    Problems and Functional Disabilities Among Patients with Cervical Disc and Relationship with Low Back Pain

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    Background: cervical disc disorder is associated with many  problems and functional disabilities which affect quality of life for patients. Neck pain is as common as low back pain which are considered from associated problems with cervical disc. Aim: This study was conducted to assess problems and functional disabilities among patients with cervical disc and relationship with low back pain. Design and Setting: A descriptive exploratory correlational study design was used and data were collected from Physical Medicine and Rehabilitation Department and it's affiliated out patient clinic of Tanta Main University Hospital. Sample: Purposive sampling of (90) patients from previous mentioned setting during follow-up period. Tools: Three tools were used for data collection: Tool (I); Sociodemographic and Medical data of the patients, Tool (II); Neck Disability Index scale to examine the degree of disability resulted from cervical disc and its effect on daily activities. Tool (III); Roland-Morris Low Back Pain and Disability Questionnaire to assess pain-related disability resulting from low back pain.  Results: As a result of this study, the majority (66.7%) of the patients had complete level of neck disability and (82.2%) of them had high level of disability due to low back pain. Moreover the majority of the patients (67.6%) had high level of disability due to low back pain associated with complete neck disability due to cervical disc. Significant positive correlation was noted between total score of neck disability index and total score of roland-morrislow back pain and disability.Conclusion and Recommendation: These results indicate that majority of the patients had complete level of neck disability and high level of disability due to low back pain. Significant positive correlation was noted between total score of neck disability index and total score of roland-morrislow back pain and disability. Further research must be done in many settings to evaluate whether disability prevention or interventions can improve functional disabilities. Keywords: Cervical disc, functional disability, Low Back Pain. DOI: 10.7176/JHMN/61-05 Publication date: April 30th 201

    BERRY EXTRACTS IMPROVED INFLAMMATORY CYTOKINES, ANTIOXIDANT ENZYME AND SUPPRESSED THE GENE EXPRESSION ALTERATIONS IN DIABETIC RATS

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    Objective: The present work was conducted to evaluate the ameliorative effect of red berry (Morus rubra) and white berry (Morus alba) extracts in diabetic rats.Methods: Inflammatory biomarkers; tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), transforming growth factor-β (TGF-β), paraoxanase1 (PON1), gene expression of apoptosis and inflammatory related genes were carried out.Results: Treatment of male rats with streptozotocin (STZ) to induce diabetes increased the levels of TNF-α, IL-1β, TGF-β, the apoptosis rates and the alterations of the pro-apoptosis (eotaxin, caspase-1, and caspase-2) and inflammation; nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB1) and allograft inflammatory factor 1 (AIF-1) related genes. While marked reduction in PON1 level was detected in STZ-induced diabetic rats. However, treatment of STZ-exposed rats with red and white berry extracts exhibited noticeable ameliorations in TNF-α, IL-1β, TGF-β levels and PON1 activity as well as low apoptosis rates and decreased the alteration of the pro-apoptosis and inflammatory related genes.Conclusion: Red and white berry extracts exhibited attenuation in antioxidant status, suppressed inflammatory cytokines, apoptosis and the alterations in the apoptosis and inflammatory related genes induced by STZ in male rats

    ANTINEURODEGENERATIVE ACTIVITY OF MICROALGAE DUNALIELLA SALINA IN RATS WITH ALZHEIMER'S DISEASE

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    Objective: The present study is aimed to investigate the promising action of Dunaliella salina extract as a natural protector against Alzheimer's disease (AD) and reported to possess a variety of activities, including antioxidant effects due to its ability to create large amount of carotenoids.Methods: D. salina is a type of halophile green microalgae was used in the present study. 50 male rats were used in this study, where aluminum chloride was orally administered to induce AD in a dose of 100 mg/kg, daily for 6 weeks. Al-intoxicated rats treated orally daily with D. salina ethanolic extract for 6 weeks in a dose of 150 mg/kg b.wt., whereas standard anti-Alzheimer drug donepezil tartrate was administered at the dose of 10 mg/kg b.wt./day for 6 consecutive weeks. The anti-Alzheimer properties of D. salina extract were achieved through measuring the calmodulin (CaM) level, paraoxonase 1 (PON1) activity, the antiapoptotic marker (Bcl2), brain-derived neurotrophic factor (BDNF), the generation of the DNA adducts (8-hydroxy-2-deoxyguanosine [8-OHdG]/2-deoxy guanosine [2-dG]), and alteration in the expression of amyloid precursor protein, β-site APP-cleaving enzyme 1 (BACE1), and β-site APP-cleaving enzyme 2 (BACE2) in AD rats.Results: The current results demonstrated that supplementation of AD rats with D. salina extract-enhanced CaM level, and increased PON1 activity, upregulated Bcl2 and BDNF, decreased the levels of DNA adducts (8-OHdG/2-dG), and suppressed the alterations of the expression levels of APP, BACE1, and BACE2-m RNAs as compared with those in AD rats.Conclusion: It could be concluded that the biological activity of D. salina extract might be regulated by 9-cis b-carotene protecting the brain cells from the oxidative stress in AD rats.Keywords: Dunaliella salina, Calmodulin, Paraoxonase 1, Bcl2, Brain-derived neurotrophic factor, Alzheimer's disease, DNA adduct, Amyloid precursor protein

    HAEMATOCOCCUS PLUVIALIS EXTRACT PROMOTING THE RECOVERY OF MEMORY IMPAIRMENT IN ALZHEIMER'S RATS: ANTI-INFLAMMATORY AND ANTIAPOPTOTIC EFFECTS

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    ABSTRACTObjective: The present study was conducted to investigate the role of Haematococcus pluvialis extract against oxidative damage, the inflammatory,and apoptotic impacts characterizing the neurodegenerative disorders.Methods: Oxidative stress, B-cell lymphoma 2, brain-derived neurotrophic factor, the inflammation, apoptotic and antiapoptotic impacts in Alzheimer'sdisease (AD) rats were determined through assessment of glutathione reduced (GSH), GSH peroxidase (GPx), lipid peroxide (malondialdehyde), thecytokines level such as tumor necrosis factor-alpha (TNF-α), interleukins (IL-6 and IL-1β), and macrophage inflammation protein (MIP1α) in AD rats.Moreover, the expression of phosphoinositide 3-kinase (PI3K) and serine-threonine protein kinase (Akt) genes regulating the apoptosis in AD ratswas measured.Results: The results revealed that levels of TNF-α, IL-6, IL-1β, and MIP1α were significantly increased in AD rats. Moreover, the expression of PI3Kand Akt genes was downregulated which it was coincided with the increase of apoptosis in AD rats. On the other hand, treatment of AD rats withH. pluvialis extract decreased the oxidative stress of AD in the form of prevention the inflammatory and apoptotic impacts.Conclusion: H. pluvialis could be used for ameliorating AD due to its role in decreases the oxidative stress of AD in the form of prevention theinflammatory and apoptotic impacts. H. pluvialis is a very attractive candidate for uses against neurodegenerative disorders that are caused byincreases oxidative stress inducing neuroinflammation and apoptosis.Keywords: Haematococcus pluvialis, Oxidative stress, Inflammation biomarkers, Apoptotic and antiapoptotic impacts

    Efficient, Recyclable, and Heterogeneous Base Nanocatalyst for Thiazoles with a Chitosan-Capped Calcium Oxide Nanocomposite

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    Calcium oxide (CaO) nanoparticles have recently gained much interest in recent research due to their remarkable catalytic activity in various chemical transformations. In this article, a chitosan calcium oxide nanocomposite was created by the solution casting method under microwave irradiation. The microwave power and heating time were adjusted to 400 watts for 3 min. As it suppresses particle aggregation, the chitosan (CS) biopolymer acted as a metal oxide stabilizer. In this study, we aimed to synthesize, characterize, and investigate the catalytic potency of chitosan–calcium oxide hybrid nanocomposites in several organic transformations. The produced CS–CaO nanocomposite was analyzed by applying different analytical techniques, including Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and field-emission scanning electron microscopy (FESEM). In addition, the calcium content of the nanocomposite film was measured using energy-dispersive X-ray spectroscopy (EDS). Fortunately, the CS–CaO nanocomposite (15 wt%) was demonstrated to be a good heterogeneous base promoter for high-yield thiazole production. Various reaction factors were studied to maximize the conditions of the catalytic technique. High reaction yields, fast reaction times, and mild reaction conditions are all advantages of the used protocol, as is the reusability of the catalyst; it was reused multiple times without a significant loss of potency

    A novel approach toward skin cancer classification through fused deep features and neutrosophic environment

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    Variations in the size and texture of melanoma make the classification procedure more complex in a computer-aided diagnostic (CAD) system. The research proposes an innovative hybrid deep learning-based layer-fusion and neutrosophic-set technique for identifying skin lesions. The off-the-shelf networks are examined to categorize eight types of skin lesions using transfer learning on International Skin Imaging Collaboration (ISIC) 2019 skin lesion datasets. The top two networks, which are GoogleNet and DarkNet, achieved an accuracy of 77.41 and 82.42%, respectively. The proposed method works in two successive stages: first, boosting the classification accuracy of the trained networks individually. A suggested feature fusion methodology is applied to enrich the extracted features’ descriptive power, which promotes the accuracy to 79.2 and 84.5%, respectively. The second stage explores how to combine these networks for further improvement. The error-correcting output codes (ECOC) paradigm is utilized for constructing a set of well-trained true and false support vector machine (SVM) classifiers via fused DarkNet and GoogleNet feature maps, respectively. The ECOC’s coding matrices are designed to train each true classifier and its opponent in a one-versus-other fashion. Consequently, contradictions between true and false classifiers in terms of their classification scores create an ambiguity zone quantified by the indeterminacy set. Recent neutrosophic techniques resolve this ambiguity to tilt the balance toward the correct skin cancer class. As a result, the classification score is increased to 85.74%, outperforming the recent proposals by an obvious step. The trained models alongside the implementation of the proposed single-valued neutrosophic sets (SVNSs) will be publicly available for aiding relevant research fields

    Targeted delivery of doxorubicin and therapeutic FOXM1 aptamer to tumor cells using gold nanoparticles modified with AS1411 and ATP aptamers

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    Objective(s): A targeted delivery platform was prepared to co-deliver both doxorubicin (Dox) as an anticancer drug and FOXM1 aptamer as a therapeutic substance to breast cancer cells (4T1 and MCF-7) to reduce Dox side effects and increase its therapeutic efficacy. The targeted system (AuNPs-AFPA) consisted of FOXM1 aptamer, AS1411 aptamer (targeting oligonucleotide), ATP aptamer, and gold nanoparticles (AuNPs) as a carrier.Materials and Methods: AuNPs were synthesized by reduction of HAuCl4. Next, after pegylation of ATP aptamer, FOXM1 aptamer-PEGylated ATP aptamer conjugate (FPA) was prepared. Then, the AS1411 aptamer and FPA were exposed to the AuNPs surface through their thiol groups. Subsequently, Dox was loaded into the complex to form a targeted therapeutic complex.Results: The data of the MTT assay displayed that the targeted complex could remarkably reduce cell viability rate in target cells due to the overexpression of nucleolin on their cell membranes compared to nontarget cells, showing the targeting ability of AuNPs-AFPA-Dox. The in vivo antitumor effect confirmed that AuNPs-AFPA-Dox was capable of remarkably diminishing tumor growth relative to the free Dox in mice bearing 4T1 tumor cells. Conclusion: The results confirmed that the targeted system improved the therapeutic effect by loading high amounts of Dox alongside the presence of the therapeutic effect of FOXM1 aptamer. Finally, it can be concluded that AuNPs-AFPA-Dox by enhancing antitumor effectiveness and reducing toxicity toward non-target cells, can be used potentially as an effective strategy for the treatment of breast cancer.
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