63 research outputs found

    Mediation of Special Education Disputes in Pennsylvania

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    Valutazione 2019-2021 «Femmes-Tische e Männer-Tische» Formazione multilingue e informale per persone in tutte le situazioni di vita

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    Femmes-Tische e Männer-Tische è un programma di formazione informale, multilingue e a bassa soglia. Il programma prevede l’organizzazione di tavole rotonde dove, alla presenza di una moderatrice o un modera1tore, si discutono temi inerenti la salute, la famiglia e l’integrazione. Il programma si basa sull’approccio tra pari e consente di raggiungere le persone con un passato migratorio che sono difficilmente raggiungibili dalle offerte tradizionali. I risultati della valutazione mostrano che le tavole rotonde portano a un aumento delle conoscenze, a una maggiore consapevolezza (del senso di responsabilità), ad atteggiamenti più positivi e a cambiamenti di abitudini tra le/i partecipanti, e quindi a un loro empowerment. Inoltre, promuovono la partecipazione sociale e offrono un supporto psicologico alle/ai partecipanti. I principali criteri di successo di questo programma sono l’accesso a bassa soglia, il confronto nella lingua d’origine, la comprensione dei ruoli specifici di donne e uomini (approccio di genere), il trasferimento di conoscenze in funzione delle esi2genze e l’approccio partecipativo. La valutazione rivela che vi è un potenziale di ottimizzazione per quanto riguarda le basi scientifiche al fine di ottenere un migliore posizionamento dell’offerta, il rafforzamento del finanziamento, i criteri di ammissione e l’affiancamento professionale delle moderatrici e dei moderatori

    Evaluation 2019–2021 «Femmes-Tische und Männer-Tische» Mehrsprachige, informelle Bildung für Menschen in allen Lebenslagen»

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    Femmes-Tische und Männer-Tische ist ein mehrsprachiges, niederschwelliges Programm der informellen Bildung. In moderierten Gesprächsrunden diskutieren Menschen zu Themen der Gesundheit, Familie und Integration. Es basiert auf dem Peer-Ansatz und erreicht Personen mit Migrationserfahrung, die über herkömmliche Angebote kaum erreicht werden. Die Evaluationsergebnisse zeigen, wie die Gesprächsrunden bei den Teilnehmenden zu einem Wissenszuwachs, einem verstärkten (Verantwortungs-)Bewusstsein, zu positiveren Einstellungen und Verhaltensänderungen und damit zu einem Empowerment führen. Zudem werden die soziale Teilhabe und die psychische Entlastung der Teilnehmenden gefördert. Zentrale Erfolgskriterien sind ein niederschwelliger Zugang, der Austausch in der Herkunftssprache, die Berücksichtigung des je spezifischen Rollenverständnisses von Frauen und Männern (Gender-Ansatz), die bedürfnisgerechte Wissensvermittlung und ein partizipativer Ansatz. Die Evaluation zeigt Optimierungspotenzial in Bezug auf die fachlichen Grundlagen zur besseren Positionierung des Angebots, die Stärkung der Finanzierung sowie die Kriterien für die Aufnahme und die fachliche Begleitung von Moderierenden

    Évaluation 2019-2021 «Femmes-Tische et Hommes-Tische». Formation multilingue et informelle pour personnes en toutes situations de vie

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    Femmes-Tische et Hommes-Tische est un programme de formation informelle et multilingue à bas seuil. Les Tables rondes menées par une animatrice ou un animateur permettent d’aborder des questions relatives à la santé, à la famille et à l’intégration. Elles reposent sur l’approche par les pairs et atteignent des personnes issues de la migration que les offres habituelles ne touchent pas ou peu. Les résultats de l’évaluation montrent que les Tables rondes résultent en un élargissement des connaissances, une prise de conscience (des responsabilités) accrue, des attitudes plus positives et des changements de comportement, donc ont pour effet l’empowerment des participant-e-s. Elles favorisent également l’intégration sociale des participant-e-s et les soulagent psychologiquement. Les principaux critères de réussite sont l’accès à bas seuil, les échanges dans la langue d’origine, la prise en compte de la compréhension des rôles spécifiques des femmes et des hommes (approche de genre), le transfert de connaissances en lien avec les besoins et l’approche participative. L’évaluation révèle un potentiel d’optimisation concernant les bases spécifiques pour un meil3leur positionnement de l’offre, le renforcement du financement ainsi que les critères d’admission et l’accompagnement professionnel des animatrices et des animateurs

    Air pollution trends in the EMEP region between 1990 and 2012

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    The present report synthesises the main features of the evolution over the 1990-2012 time period of the concentration and deposition of air pollutants relevant in the context of the Convention on Long-range Transboundary Air Pollution: (i) ozone, (ii) sulfur and nitrogen compounds and particulate matter, (iii) heavy metals and persistent organic pollutants. It is based on observations gathered in State Parties to the Convention within the EMEP monitoring network of regional background stations, as well as relevant modelling initiatives. Joint Report of: EMEP Task Force on Measurements and Modelling (TFMM), Chemical Co-ordinating Centre (CCC), Meteorological Synthesizing Centre-East (MSC-E), Meteorological Synthesizing Centre-West (MSC-W)

    Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

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    In the version of this article initially published, the author affiliations incorrectly listed “Candiolo Cancer Institute FPO-IRCCS, Candiolo (TO), Italy” as “Candiolo Cancer Institute, Candiolo, Italy.” The change has been made to the HTML and PDF versions of the article

    Формирование эмоциональной культуры как компонента инновационной культуры студентов

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    Homozygosity has long been associated with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity, ROH), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power3,4. Here we use ROH to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts and find statistically significant associations between summed runs of homozygosity (SROH) and four complex traits: height, forced expiratory lung volume in 1 second (FEV1), general cognitive ability (g) and educational attainment (nominal p<1 × 10−300, 2.1 × 10−6, 2.5 × 10−10, 1.8 × 10−10). In each case increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing convincing evidence for the first time that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples5,6, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein (LDL) cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection7, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been

    Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

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    OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
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