11 research outputs found

    Demographic data and clinical characterization of individuals participating in a faces matching functional MRI study.

    No full text
    <p>Abbreviations: BD, bipolar disorder; HC, healthy controls; SD, standard deviation; WASI, Wechsler Abbreviated Scale of Intelligence; IDS, Inventory of Depressive Symptoms; YMRS, Young Mania Rating Scale; PANSS P score, Positive and Negative Syndrome Scale positive subscale; GAF-S, Global Assessment of Functioning–symptom score; GAF-F, Global Assessment of Functioning–function score; BD PGRS, bipolar disorder polygenic risk score; ms, milliseconds.</p><p>BD PGRS values are reported as z-scores (with SD in brackets).</p><p>Complete behavioral data (response times and accuracy rates per condition) were available for 80/85 BD and 119/121 HC. For the remaining individuals (5 BD, 2 HC), an accuracy rate for each session (i.e. a combined rate for negative faces and shapes, and for positive faces and shapes) was available and was used to confirm that the participants paid attention to the task (accuracy rate: 97.4% and 96.0%, respectively).</p><p><sup>a</sup> Mean age at fMRI scanning. Age range was 18 to 63.</p><p><sup>b</sup> IDS score at scanning was available for 60/85 individuals (70.6%).</p><p><sup>c</sup> YMRS score at scanning was available for 69/85 individuals (81.2%).</p><p><sup>d</sup> PANSS P score at scanning was available for 38/85 individuals (44.7%).</p><p><sup>e</sup> Last six months</p><p>Demographic data and clinical characterization of individuals participating in a faces matching functional MRI study.</p

    Significant clusters at whole-brain level for diagnostic category and polygenic risk score analyses, corrected for sex and age.

    No full text
    <p>*Remains significant after Bonferroni correction (8 independent tests)</p><p><sup>#</sup>P < 0.05 with IQ and education in model</p><p>Abbrevations: Pos, Positive; Neg, Negative; HC, healthy controls; BD, bipolar disorder; PGRS, polygenic risk score; L, left; R, right. ‘+’, positively associated; ‘-’, negatively associated.</p><p>Coordinates are given in MNS space.</p><p>Significant clusters at whole-brain level for diagnostic category and polygenic risk score analyses, corrected for sex and age.</p

    Kaplan–Meier estimates and Cox proportional hazard model fits from the ADGC Phase 1 case–control dataset, excluding NIA ADC and ADNI samples.

    No full text
    <p>The proportional hazard assumptions were checked based on graphical comparisons between Kaplan–Meier estimations (dashed lines) and Cox proportional hazard models (solid lines). The 95% confidence intervals of Kaplan–Meier estimations are also demonstrated (shaded with corresponding colors). The baseline hazard (gray line) in this model is based on the mean of ADGC data. ADGC, Alzheimer’s Disease Genetics Consortium; ADNI, Alzheimer’s Disease Neuroimaging Initiative; NIA ADC, National Institute on Aging Alzheimer’s Disease Center; PHS, polygenic hazard score.</p

    Annualized incidence rates showing the instantaneous hazard as a function of polygenic hazard score percentile and age.

    No full text
    <p>The gray line represents the population baseline estimate. Dashed lines represent incidence rates in <i>APOE</i> ε4 carriers (dark red dashed line) and non-carriers (light blue dashed line) not associated with a PHS percentile. The asterisk indicates that the baseline estimation is based on previously reported annualized incidence rates by age in the general US population [<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1002258#pmed.1002258.ref018" target="_blank">18</a>]. PHS, polygenic hazard score.</p
    corecore