475 research outputs found

    Evolution of the Bavarian dialect lexical system

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    The article deals with the specific features of the German language on the Bavarian dialect lexical level. The dialect is remarkable for its innovations and variety of linguistic forms on all levels of its system. The notion “Bavarian dialect” and its correlation with literary German language is being researched. The comparative analysis reveals the facts of deviation from the standards of the literary German language, especially in vocabulary and semantic

    Comparative study of electrophoretic deposition of doped BaCeO3-based films on La2NiO4+δ and La1.7Ba0.3NiO4+δ cathode substrates

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    This paper presents the results of a comparative study of methods to prevent the loss of barium during the formation of thin-film proton-conducting electrolyte BaCe0.89Gd0.1Cu0.01O3-δ (BCGCuO) on La2NiO4+δ-based (LNO) cathode substrates by electrophoretic deposition (EPD). Three different methods of the BCGCuO film coating were considered: the formation of the BCGCuO electrolyte film without (1) and with a protective BaCeO3 (BCO) film (2) on the LNO electrode substrate and the formation of the BCGCuO electrolyte film on a modified La1.7Ba0.3NiO4+δ (LBNO) cathode substrate (3). After the cyclic EPD in six stages, the resulting BCGCuO film (6 μm) (1) on the LNO substrate was completely dense, but the scanning electron microscope (SEM) analysis revealed the absence of barium in the film caused by its intensive diffusion into the substrate and evaporation during the sintering. The BCO layer prevented the barium loss in the BCGCuO film (2); however, the protective film possessed a porous island structure, which resulted in the deterioration of the film's conductivity. The use of the modified LBNO cathode also effectively prevented the loss of barium in the BCGCuO film (3). A BCGCuO film whose conductivity behavior most closely resembled that of the compacts was obtained by using this method which has strong potential for practical applications in solid oxide fuel cell (SOFC) technology. © 2019 by the authors.Government Council on Grants, Russian FederationFunding: This research was funded by the Government of the Russian Federation (Agreement 02.A03.21.0006, Act 211)

    The practice of using FMEA-analysis at a Russian industrial enterprise

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    Поэтапное описание внедрения методики FMEA на российском предприятии, влияние внедрения методики на производственный процесс и качество продукции. Актуальные проблемы, возникающие при внедрении методики на производстве.A phased description of the implementation of the FMEA methodology in a Russian enterprise, the impact of the implementation of the methodology on the production process and product quality. Actual problems arising from the introduction of methods in production

    Challenges of Formation of Thin-film Solid Electrolyte Layers on Non-Conductive Substrates by Electrophoretic Deposition

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    In this work, the challenges associated with the formation of single and bilayer coatings based on Ce0.8 Sm0.2 O1.9 (SDC) and CuO modified BaCe0.5 Zr0.3 Y0.1 Yb0.1 O3−δ (BCZYYbO-CuO) solid state electrolytes on porous non-conducting NiO-SDC anode substrates by the method of electrophoretic deposition (EPD) are considered. Various approaches that had been selected after analysis of the literature data in order to carry out the EPD, are tested: direct deposition on a porous non-conductive anode substrate and multiple options for creating the conductivity of the anode substrate under EPD conditions such as the reduction of the NiO-SDC substrate and the creation of a surface conducting sublayer via synthesizing a polypyrrole (PPy) film. New effective method was proposed based on the deposition of a platinum layer on the front side of the substrate. It was ascertained that, during the direct EPD on the porous NiO-SDC substrate, the formation of a continuous coating did not occur, which may be due to insufficient porosity of the substrate used. It was shown that the use of reduced substrates leads to cracking and, in some cases, to the destruction of the entire SDC/NiO-SDC structure. The dependence of the electrolyte film sinterability on the substrate shrinkage was studied. In contrast to the literature data, the use of the substrates with a reduced pre-sintering temperature had no pronounced effect on the densification of the SDC electrolyte film. It was revealed that complete sintering of the SDC electrolyte layer with the formation of a developed grain structure is possible at a temperature of 1550◦ C. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Funding: The work was financially supported by the Russian Foundation for Basic Research, grant № 20-03-00151. Investigation of the kinetic properties of the suspensions was performed within the framework of the state assignment of IEP UB RAS (EPD thin-layer coatings, No. AAAA-A19-119061090040-7). The study was in part carried out on the equipment of the Shared Access Center of “Composition of compounds” IHTE UB RAS and the Shared Access Centers of the IEP UB RAS and ISSC UB RAS

    A unified design for validation of methods for quality control of blood components

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    Quality assurance of transfusion media is a fundamental principle of the functioning of all blood service institutions, allowing guaranteeing the safety of the recipient. An integral part of the procuring process of blood components is their laboratory testing, which results reliability and reproducibility can be proved by carrying out of validation of analytical methods. The aim of the study was to define the rules for planning and carrying out validation tests of methods for quality control of blood components, including verification of their compliance with established acceptance criteria. Material and methods. The analysis of the literature about the safety of blood components and the quality of laboratory tests was carried out with an assessment of the applied significance of the information proved. Results and discussion. As a result of the work done, a unified model for confirming of the accuracy of determining of the safety indicators of transfusion media was created, which contributes to improving of the quality of donor biomaterial and the effectiveness of therapy. Conclusions. The presented validation design is relevant for medical organizations working in the sphere of blood donation and its components

    Factors of successful diversification for machine-building enterprises

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    The relevance of the study is due to the need to diversify production in order to increase competitiveness and strengthen the economic sustainability of enterprises. Increasing the output of high-tech civil and dual-use products by enterprises of the military-industrial complex as part of the conversion is complicated by the lack of enterprises work experience in the market. Conversion of defense industry enterprises is an important and promising task, the solution of which is connected with the future of defense industry enterprises, the development of import substitution, the expansion of high-tech exports. The purpose of the study is to analyze the world experience of conversion, to study existing approaches to solving conversion implementation problems, creating a system of conversion success factors, monitoring the effect of external and internal conversion implementation factors, identifying actual problems of this process. The author's approach to solving conversion problems consists of identifying external and internal conversion success factors and combining them into a single system for the interaction between the state and defense enterprises. The study of the implementation of the indicated factors showed the degree of their development, as well as the directions that will contribute to the development of diversification. © Published under licence by IOP Publishing Ltd

    Tyrosine hydroxylase of the brain and it’s regulation by glucocorticoids

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    Early life stress events can produce long-lasting changes in neurochemistry and behaviors related to monoamine systems, with increased risks of cardiovascular, metabolic, neuroendocrine, psychiatric disorders, generalized anxiety and depression in adulthood. Tyrosine hydroxylase (TH), the key enzyme for catecholamine synthesis, also plays an important role in the activity of the noradrenergic system and may be a target for glucocorticoids during the perinatal programming of physiological functions and behavior. Administration of hydrocortisone or dexamethasone to female rats on day 20 of pregnancy and to 3-day-old neonatal pups significantly increased TH mRNA levels (real-time PCR) and enzyme activity as well as protein levels determined by ICH in the locus coeruleus. Moreover, our treatment led to increase in TH mRNA levels in 25- and 70-day-old animals, as well as an increase in enzyme activity in the brainstem and cerebral cortex of adult rats. The long-term changes in TH expression are limited by the perinatal period of development. Administration of hormones on day 8 of life was not accompanied by changes in TH mRNA levels or enzyme activity. Glucocorticoids use several mechanisms to bring about transactivation or transrepression of genes. The main mechanism includes direct binding of the hormone-activated GRs to glucocorticoid responsive elements (GREs) in the promoter region of genes. However, despite optimistic claims made the classical GRE was not found in the TH gene promoter. Protein – protein interactions between hormone-activated GR and other transcription factors, for example, AP-1, provide an additional mechanism for the effects of glucocorticoids on gene expression. An important feature of this mechanism is its dependence on the composition of proteins formed by AP-1. Hormone-activated GRs are able to enhance gene expression when AP-1 consists of the Jun / Jun homodimer, but do not do that when AP-1 appears as the Jun / Fos heterodimer. Furthermore, as has been shown recently, the GRE / AP-1 composite site is the major site of interaction of glucocorticoids with  the TH gene in the pheochromocytoma cell line. Ontogenetic variation in the expression of Fos and Jun family proteins, which affects their ratio, can be one of the reasons for the TH gene regulation by glucocorticoids at near-term fetuses and neonates. However, to date this hypothesis has been supported only by in vitro data, and the existence of this mechanism in in vivo conditions needs to be explored in further studies

    The lower ionosphere response to its disturbances by powerful radio waves

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    © 2017. The paper presents data from some campaigns at Sura heating facility in 2011-1016. The experiments on probing of the artificial disturbed region of the lower ionosphere were carried out at two observation sites. One of them was located near Vasil'sursk 1. km from Sura facility (56.1°N; 46.1°E) and the other site was located at the Observatory (55.85°N; 48.8°E) of Kazan State University, 170. km to the East. Investigation of the features of the disturbed region of the lower ionosphere based on its diagnostics by the methods of the vertical sounding and oblique backscattering is the main goal of this paper. Ionosphere disturbance was fulfilled by the effect of the powerful radio wave of the ordinary or extraordinary polarization emitted by transmitters of the Sura facility with effective radiated power ERP = 50-120. MW at the frequency of 4.3, 4.7 and 5.6. MHz. Pumping waves were emitted with period from 30. s to 15. min. The disturbed region of the ionosphere in Vasil'sursk was probed by the vertical sounding technique using the partial reflexion radar at the frequency of 2.95 and 4.7. MHz. For the oblique sounding of the disturbed region the modified ionosonde Cyclon-M, operating at ten frequencies from 2.01 to 6.51. MHz was used at the Observatory site. On many heating sessions simultaneous variations of the probing partial reflection signals in Vasil'sursk and backscattered signals in Observatory were observed at the height at 40-100. km below the reflection height of the pumping wave. These observations were correlated with the pumping periods of the Sura facility. Possible mechanisms of the appearance of the disturbance in the lower ionosphere and its effect on the probing radio waves are discussed
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