12 research outputs found

    Atlantic Flyway Review: Region I (Northeast)- Fall 2012 Monomoy Refuge Banding Station

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    Atlantic Flyway Review: Region 1 (Northeast)- Fall 2014- Monomoy Refuge Banding Station

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    Atlantic Flyway Review: Region I (Northeast) Fall 2016- Austin Banding Station

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    Atlantic Flyway Review: Region 1 (Northeast)- Fall 2014- Austin Banding Station

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    Atlantic Flyway Review: Region I (Northeast)- Fall 2015-Austin Banding Station

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    Variation in nest defense response by four raptor species to the use of a rotary-winged unmanned aerial vehicle (or drone) for censusing nest contents

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    Unmanned Aerial Vehicles (UAV) or “drones” now offer a viable alternative to traditional technologies for a wide variety of data collection tasks, but little work has been done investigating the response of wildlife to these devices. This M.Sc. thesis covers the use of a Draganflyer X-4 rotary-winged quad-copter mounted with a camera to safely and accurately census the nest contents of four raptor species: Osprey (Pandion haliaetus), Bald Eagle (Haliaeetus leucocephalus), Ferruginous Hawk (Buteo regalis) and Red-tailed Hawk (B. jamaicensis). The aircraft proved effective for documenting nest contents of each species when a proper flight technique, one that takes into account bird and human safety, is adopted, practiced, and executed. Additionally the reaction of each individual to the UAV and researchers was documented, allowing for the quantification of parental response to the aircraft. In the vast majority of situations a successful flight was completed and, with the exception of a single instance, no contact was made between the adult birds and the aircraft. This technique has been shown to be both effective and useful; this combined with both the development of technology and lowering of costs, should lead to a rapid expansion of UAVs for the censusing of raptor and other large bird nests.Les véhicules aériens sans pilote (UAV) ou “drones” présentent une nouvelle alternative viable aux technologies traditionnelles pour la collecte de données de toutes sortes, mais on en sait toujours peu sur les réactions des diverses espèces animales à ces appareils. Ce mémoire de maîtrise ès sciences documente l’usage d’un quadcopter à voilure tournante Draganflyer X-4 doté d’une caméra pour recenser de façon précise et sécuritaire le contenu des nids de quatre espèces d’oiseaux de proie : le balbuzard pêcheur (Pandion haliaetus), le pygargue à tête blanche (Haliaeetus leucocephalus), la buse rouilleuse (Buteo regalis) et la buse à queue rousse (B. jamaicensis). Lorsque des techniques de vol appropriées, qui mettent l’accent sur la sécurité des oiseaux et des chercheurs, sont adoptées et mises en pratique, l’appareil se révèle très efficace pour l’observation de chaque espèce. De plus, les comportements de chaque individu face à l’UAV et aux chercheurs ont été documentés pour permettre la quantification des réactions parentales à l’appareil. Dans la grande majorité des cas, sauf une exception, des images ont été obtenues avec succès sans contact direct entre l’appareil et un oiseau. Les techniques ont démontré leur efficacité et leur viabilité sur le terrain; compte tenu du développement rapide et du coût décroissant de cette technologie, l’usage d’UAV devrait être popularisé pour le recensement d’oiseaux de proie et autres espèces nicheuses

    Nest Defense Behaviour of Four Raptor Species (Osprey, Bald Eagle, Ferruginous Hawk and Red-tailed Hawk) to a Novel Aerial Intruder – A Small Rotary-winged Drone

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    A small rotary-winged Unmanned Aerial Vehicle (UAV) was flown above the nests of four raptor species: Osprey (Pandion haliaetus), Bald Eagle (Haliaeetus leucocephalus), Ferruginous Hawk (Buteo regalis) and Red-tailed Hawk (B. jamaicensis) to document the parental nest defense response to the aircraft. Adult behaviour was documented with a voice recorder and an Ethogram, starting ~100m distant from the nest and continuing until the base of the nest was reached, the survey completed, and the nest area exited. All adult movements and vocalizations were recorded with distance of bird and researchers from the nest when a given behaviour occurred. Ospreys showed the strongest nest defense response followed by Ferruginous Hawks and Red-tailed Hawks with Bald Eagles showing the least aggressive response. Ospreys showed no greater response to the UAV in the air near the nest than to researchers simply standing at the base of the nest structure, while Bald Eagles showed a significantly higher response to the aircraft than researchers at the nest base. Although aggression varied, no species showed aggression at levels that would discourage the use of UAVs to survey raptor nests. When a proper flight technique is adopted, UAVs can offer a useful tool for surveying raptor nests.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

    Rice XA21 Binding Protein 3 Is a Ubiquitin Ligase Required for Full Xa21-Mediated Disease Resistance

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    XA21 is a receptor-like kinase protein in rice (Oryza sativa) that confers gene-for-gene resistance to specific races of the causal agent of bacterial blight disease, Xanthomonas oryzae pv oryzae. We identified XA21 binding protein 3 (XB3), an E3 ubiquitin ligase, as a substrate for the XA21 Ser and Thr kinase. The interaction between XB3 and the kinase domain of XA21 has been shown in yeast and in vitro, and the physical association between XB3 and XA21 in vivo has also been confirmed by coimmunoprecipitation assays. XB3 contains an ankyrin repeat domain and a RING finger motif that is sufficient for its interaction with the kinase domain of XA21 and for its E3 ubiquitin ligase activity, respectively. Transgenic plants with reduced expression of the Xb3 gene are compromised in resistance to the avirulent race of X. oryzae pv oryzae. Furthermore, reduced levels of Xb3 lead to decreased levels of the XA21 protein. These results indicate that Xb3 is necessary for full accumulation of the XA21 protein and for Xa21-mediated resistance

    Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease

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    Based on a multitarget strategy, a series of novel chromanone-1-benzyl-1,2,3,6-tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer's disease (AD). Biological evaluation demonstrated that these hybrids exhibited significant inhibitory activities toward acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B). The optimal compound C10 possessed excellent dual AChE/MAO-B inhibition both in terms of potency and equilibrium (AChE: IC50 = 0.58 ± 0.05 μM; MAO-B: IC50 = 0.41 ± 0.04 μM). Further molecular modeling and kinetic investigations revealed that compound C10 was a dual-binding inhibitor bound to both the catalytic anionic site and peripheral anionic site of AChE. In addition, compound C10 exhibited low neurotoxicity and potently inhibited AChE enzymatic activity. Furthermore, compound C10 more effectively protected against mitochondrial dysfunction and oxidation than donepezil, strongly inhibited AChE-induced amyloid aggregation, and moderately reduced glutaraldehyde-induced phosphorylation of tau protein in SH-SY5Y cells. Moreover, compound C10 displayed largely enhanced improvements in cognitive behaviors and spatial memory in a scopolamine-induced AD mice model with better efficacy than donepezil. Overall, the multifunctional profiles of compound C10 suggest that it deserves further investigation as a promising lead for the prospective treatment of AD

    Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer’s Disease

    No full text
    Based on a multitarget strategy, a series of novel chromanone–1-benzyl-1,2,3,6-tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer’s disease (AD). Biological evaluation demonstrated that these hybrids exhibited significant inhibitory activities toward acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B). The optimal compound C10 possessed excellent dual AChE/MAO-B inhibition both in terms of potency and equilibrium (AChE: IC50 = 0.58 ± 0.05 μM; MAO-B: IC50 = 0.41 ± 0.04 μM). Further molecular modeling and kinetic investigations revealed that compound C10 was a dual-binding inhibitor bound to both the catalytic anionic site and peripheral anionic site of AChE. In addition, compound C10 exhibited low neurotoxicity and potently inhibited AChE enzymatic activity. Furthermore, compound C10 more effectively protected against mitochondrial dysfunction and oxidation than donepezil, strongly inhibited AChE-induced amyloid aggregation, and moderately reduced glutaraldehyde-induced phosphorylation of tau protein in SH-SY5Y cells. Moreover, compound C10 displayed largely enhanced improvements in cognitive behaviors and spatial memory in a scopolamine-induced AD mice model with better efficacy than donepezil. Overall, the multifunctional profiles of compound C10 suggest that it deserves further investigation as a promising lead for the prospective treatment of AD
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