5 research outputs found

    Relationship between the TRIM24 expression and the clinicopathological factors.

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    <p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0085462#pone-0085462-t001" target="_blank">Table 1:</a> a. Missing data for 2 patients. b. Missing data for 3 patients. c. Missing data for 1 patient. d. Missing data for 10 patients; 7 patients were excluded according to the inclusion criteria. *.We defined that those patients whose recurrence time is less than 6 months as intrahepatic metastasis.</p

    Immunohistochemical staining of TRIM24 in tissue sections.

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    <p>A. Negative staining in normal liver tissue. B. Negative staining in benign liver lesions tissues (Hepatic hemangioma). C. Negative TRIM24 staining in an AFP>400 ug/L, well differentiated HCC tissue. D. Positive TRIM24 staining in an AFP<400 ug/L, moderate differentiated HCC tissue. E. Negative TRIM24 staining in an AFP<400 ug/L,well differentiated HCC tissue. F&G. Positive TRIM24 staining in an AFP>400 ug/L, poor differentiated HCC tissue. H. Negative control using antibody diluent.</p

    Depletion of TRIM24 inhibits the process of EMT.

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    <p>5(A). Western blotting analysis of the cell-apoptosis related proteins showed the expression of E-cadherin was increased and Snail, Slug, Vimentin, and╬▓-catenin were decreased after knockdown TRIM24 in HepG2 cells; 5(B). Reduced migration and invasion ability of HepG2 cells at 48 h post-transfection with siTRIM24 (P<0.05, compared with controls).</p

    Depletion of TRIM24 reduces cell proliferation.

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    <p>4(A). Western blotting analysis of the cell-cycle related proteins showed the expression of Cyclin D1 and CDK4 were decreased but showed no significant change in p21 after knockdown TRIM24 in HepG2 cells; 4(B). Cell cycle analyses showed that the percentage of G1 phase was increased in siTRIM24 group (P<0.05), whereas the percentages of S phase (P<0.05) and G2 phase (P<0.05) were decreased in the TRIM24 knockdown cells compared with control cells; 4(C) CCK-8 assay suggested that cell proliferation of HepG2 after TRIM24 silencing was reduced compared with the control group.</p
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