4,904 research outputs found

    The physics potential of the ATLAS experiment at the LHC

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    The ATLAS experiment at the LHC has a large discovery potential for physicsbeyond the Standard Model and in the investigation of the nature of electroweaksymmetry breaking. The large event rates provided by the high luminosity LHC machine will, however, also allow to perform precision measurements of importantStandard Model parameters. Both the discovery potential for new physics and themeasurements of Standard Model parameters are summarized in the present paper

    Standardisation, Innovation and Implementation of Information Technology

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    This paper looks at the mutual interplay between information technology (IT) and its environment. Exploring specifically the issues surrounding innovations in the field of corporate IT systems we show that a distinction has to be made between different categories of information technology (IT) systems regarding their introduction, subsequent diffusion, and particularly their corporate usage. We will show that strategic deployment of e-mail will only happen if and when it is no longer considered an infrastructural technology. However, apparently this has rarely happened thus far. Strong relations and dependencies exist between standardiation, innovation and the subsequent implementation of IT systems. We argue that these activities must not be considered separately, especially as standards-based components are playing an increasingly important role in implementation processes. Consequently, the role of the users in, and their influence on, standards setting are addressed as well. The findings and conclusions presented are largely based on a number of interview

    Introducing IT: Lessons from Case Studies of Email

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    Higgs and SUSY at the LHC: prospects for luminosities above 1 fb−1^{-1}

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    The prospects for Higgs and SUSY searches for integrated luminosities exceeding 1 fb-1 are discussed

    Prospects for the Search for a Standard Model Higgs Boson in ATLAS using Vector Boson Fusion

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    The potential for the discovery of a Standard Model Higgs boson in the mass range m_H < 2 m_Z in the vector boson fusion mode has been studied for the ATLAS experiment at the LHC. The characteristic signatures of additional jets in the forward regions of the detector and of low jet activity in the central region allow for an efficient background rejection. Analyses for the H -> WW and H -> tau tau decay modes have been performed using a realistic simulation of the expected detector performance. The results obtained demonstrate the large discovery potential in the H -> WW decay channel and the sensitivity to Higgs boson decays into tau-pairs in the low-mass region around 120 GeV.Comment: 20 pages, 13 ps figures, uses EPJ style fil

    The oxidation status of Mic19 regulates MICOS assembly.

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    The function of mitochondria depends on the proper organization of mitochondrial membranes. The morphology of the inner membrane is regulated by the recently identified mitochondrial contact site and cristae organizing system (MICOS) complex. MICOS mutants exhibit alterations in crista formation, leading to mitochondrial dysfunction. However, the mechanisms that underlie MICOS regulation remain poorly understood. MIC19, a peripheral protein of the inner membrane and component of the MICOS complex, was previously reported to be required for the proper function of MICOS in maintaining the architecture of the inner membrane. Here, we show that human and yeast MIC19 proteins undergo oxidation in mitochondria and require the mitochondrial intermembrane space assembly (MIA) pathway, which couples the oxidation and import of mitochondrial intermembrane space proteins for mitochondrial localization. Detailed analyses identified yeast Mic19 in two different redox forms. The form that contains an intramolecular disulfide bond is bound to Mic60 of the MICOS complex. Mic19 oxidation is not essential for its integration into the MICOS complex but plays a role in MICOS assembly and the maintenance of proper inner membrane morphology. These findings suggest that Mic19 is a redox-dependent regulator of MICOS function