4,986 research outputs found

    A study of the relationship between special education emotional support behaviorally disordered students and their moral reasoning

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    Very few studies have examined moral reasoning in students identified as having behavioral disorders and enrolled in a special education setting. Little attention has been paid to the impact of interventional education programs designed for behaviorally disordered youth on moral reasoning development. The research examined the moral reasoning of behaviorally disordered adolescents enrolled in a self-contained high school setting. The results indicate that behaviorally disordered emotional support high school students are significantly lower in moral reasoning compared to their nonbehaviorally disordered peers. The development of moral reasoning has been considered an important component of both social and cognitive growth in children and adolescents (Kohlberg, 1969; Piaget, 1932/1965). Recently, researchers have called for the development and implementation of moral education interventions for behaviorally disordered students (Maag, 1989; Swarthout, 1988). This increased interest in improving the moral reasoning of behaviorally disordered youth has been spurred, in part, by research findings suggesting that deficits in moral reasoning are related to adult adjustment difficulties (Kohlberg, LaCrosse, & Ricks, 1972). Further evidence suggests that it is possible to elevate the moral reasoning ability of these youths and that this increased level of moral reasoning is associated with decreases in problem behaviors (Arbuthnot & Gordon, 1986)

    Agglomeration, Networking and the Great Recession

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    This paper analyzes how and to what extent firms’ external relations, such as belonging to a local cluster or a business group, affect the probability of firm survival and economic performance after the 2008 Great Recession. Using a large data set of Italian manufacturing companies for the period 2005–12, it was found that belonging to a business group or a local cluster mitigates the selection effect determined by the real and financial shocks, while in the case of firms not belonging to groups, only the more efficient units survive. This means that firms belonging to a group or local cluster are expected to show a lower likelihood of failure and also lower performance compared with stand-alone firms

    Geomorphology of the lower Mesopotamian plain at Tell Zurghul archaeological site

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    The landscape of the Lower Mesopotamia Plain (LMP) has been moulded by water-related processes, consequently, its Holocene geomorphic evolution has been strictly connected to the fluvial process and the anthropogenic water management since 8000 BC. About 6000 years ago, during the maximum marine ingression, the modern cities of Nasiriyah and Al-Amara were close to the Persian Gulf shoreline. Successively, the Tigris and Euphrates developed two wide delta systems, that prograded south-eastward developing a complex fluvial network. Remote sensing investigations over the LMP using satellite imagery and topographic analysis revealed the surficial expression of deltaic bodies with a lobate planform and several terminal distributary channels (TDCs), classifiable as tidal-influenced river-dominated deltas. Tell Zurghul archaeological site, belonging to the ancient State of Lagash, expanded in the western part of the recognized TDC during the Mid- and Late Holocene. Indeed, the occurrence of a divergent multi-channel system supplied water for the early civilizations, which improved the water management and prevented floods through a canals network. Therefore, the multi-sensor remote sensing approach over an area of 2850 km2 allowed us to recognize several fluvial landforms, both still active and relict, attributable to the Holocene riverscape of the LMP, as well as anthropogenic features and aeolian deposits. The Main map is a geomorphological map at the scale of 1:120,000 centred on Tell Zurghul, focusing on the geometry, spatial distribution, and state of activity of erosional and constructional landforms

    The cell cycle checkpoint inhibitors in the treatment of leukemias

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    open3noThe study was funded by the University of Bologna and by the Italian Association for Cancer Research (AIRC).The inhibition of the DNA damage response (DDR) pathway in the treatment of cancers has recently reached an exciting stage with several cell cycle checkpoint inhibitors that are now being tested in several clinical trials in cancer patients. Although the great amount of pre-clinical and clinical data are from the solid tumor experience, only few studies have been done on leukemias using specific cell cycle checkpoint inhibitors. This review aims to summarize the most recent data found on the biological mechanisms of the response to DNA damages highlighting the role of the different elements of the DDR pathway in normal and cancer cells and focusing on the main genetic alteration or aberrant gene expression that has been found on acute and chronic leukemias. This review, for the first time, outlines the most important pre-clinical and clinical data available on the efficacy of cell cycle checkpoint inhibitors in single agent and in combination with different agents normally used for the treatment of acute and chronic leukemias.openGhelli Luserna di Rora', A; Iacobucci, I; Martinelli, GGhelli Luserna di Rora', A; Iacobucci, I; Martinelli,

    Nilotinib: a novel encouraging therapeutic option for chronic myeloid leukemia patients with imatinib resistance or intolerance

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    Although high rates of complete hematologic and cytogenetic remission have been observed in patients with chronic phase chronic myeloid leukemia (CML) treated with imatinib, a short duration of response with eventual emergence of imatinib resistance has also been reported in a subset of CML patients. The most frequent clinically relevant mechanisms that change imatinib sensitivity in BCR-ABL-transformed cells are mutations within the Abl kinase domain, affecting several of its properties. Crystal structure analysis of the Abl-imatinib complex has proven helpful in identifying potential critical residues that hinder interactions of imatinib with mutated Abl. This has led to the development of a second generation of targeted therapies such as nilotinib and dasatinib, already in phase II clinical trials or SKI-606 and MK-0457 in phase I trials. In this review, we discuss the activity of nilotinib, developed by Novartis using a rational drug design strategy in which imatinib served as the lead compound. Preliminary studies demonstrated that nilotinib has more efficacy than imatinib in inhibiting proliferation of BCR-ABL-dependent cells, a relatively safety profile and clinical efficacy in all phases of CML

    Prototyping of an HV-CMOS demonstrator for the High Luminosity-LHC upgrade

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    HV-CMOS sensors can offer important advantages in terms of material budget, granularity and cost for large area tracking systems in high energy physics experiments. This article presents the design and simulated results of an HV-CMOS pixel demonstrator for the High Luminosity-LHC. The pixel demonstrator has been designed in the 0.35 ÎŒm HV-CMOS process from ams AG and submitted for fabrication through an engineering run. To improve the response of the sensor, different wafers with moderate to high substrate resistivities are used to fabricate the design. The prototype consists of four large analog and standalone matrices with several pixel flavours, which are all compatible for readout with the FE-I4 ASIC. Details about the matrices and the pixel flavours are provided in this article

    Characterisation of AMS H35 HV-CMOS monolithic active pixel sensor prototypes for HEP applications

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    Monolithic active pixel sensors produced in High Voltage CMOS (HV-CMOS) technology are being considered for High Energy Physics applications due to the ease of production and the reduced costs. Such technology is especially appealing when large areas to be covered and material budget are concerned. This is the case of the outermost pixel layers of the future ATLAS tracking detector for the HL-LHC. For experiments at hadron colliders, radiation hardness is a key requirement which is not fulfilled by standard CMOS sensor designs that collect charge by diffusion. This issue has been addressed by depleted active pixel sensors in which electronics are embedded into a large deep implantation ensuring uniform charge collection by drift. Very first small prototypes of hybrid depleted active pixel sensors have already shown a radiation hardness compatible with the ATLAS requirements. Nevertheless, to compete with the present hybrid solutions a further reduction in costs achievable by a fully monolithic design is desirable. The H35DEMO is a large electrode full reticle demonstrator chip produced in AMS 350 nm HV-CMOS technology by the collaboration of Karlsruher Institut f\"ur Technologie (KIT), Institut de F\'isica d'Altes Energies (IFAE), University of Liverpool and University of Geneva. It includes two large monolithic pixel matrices which can be operated standalone. One of these two matrices has been characterised at beam test before and after irradiation with protons and neutrons. Results demonstrated the feasibility of producing radiation hard large area fully monolithic pixel sensors in HV-CMOS technology. H35DEMO chips with a substrate resistivity of 200Ω\Omega cm irradiated with neutrons showed a radiation hardness up to a fluence of 101510^{15}neq_{eq}cm−2^{-2} with a hit efficiency of about 99% and a noise occupancy lower than 10−610^{-6} hits in a LHC bunch crossing of 25ns at 150V

    Test beam measurement of the first prototype of the fast silicon pixel monolithic detector for the TT-PET project

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    The TT-PET collaboration is developing a PET scanner for small animals with 30 ps time-of-flight resolution and sub-millimetre 3D detection granularity. The sensitive element of the scanner is a monolithic silicon pixel detector based on state-of-the-art SiGe BiCMOS technology. The first ASIC prototype for the TT-PET was produced and tested in the laboratory and with minimum ionizing particles. The electronics exhibit an equivalent noise charge below 600 e- RMS and a pulse rise time of less than 2 ns, in accordance with the simulations. The pixels with a capacitance of 0.8 pF were measured to have a detection efficiency greater than 99% and, although in the absence of the post-processing, a time resolution of approximately 200 ps
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