13 research outputs found

    Far from Naples. The Stinche’s role in the manuscript tradition of the “Caccia di Diana”

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    This essay focuses on the role of two manuscript witnesses written at the Florentine municipal prison, called the Stinche, in the context of the manuscript tradition of the Caccia di Diana (Diana’s Hunt)

    Antifungal activity of amphotericin B conjugated to nanosized magnetite in the treatment of paracoccidioidomycosis

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    This study reports on in vitro and in vivo tests that sought to assess the antifungal activity of a newly developed magnetic carrier system comprising amphotericin B loaded onto the surface of pre-coated (with a double-layer of lauric acid) magnetite nanoparticles. The in vitro tests compared two drugs; i.e., this newly developed form and free amphotericin B. We found that this nanocomplex exhibited antifungal activity without cytotoxicity to human urinary cells and with low cytotoxicity to peritoneal macrophages. We also evaluated the efficacy of the nanocomplex in experimental paracoccidioidomycosis. BALB/c mice were intratracheally infected with Paracoccidioides brasiliensis and treated with the compound for 30 or 60 days beginning the day after infection. The newly developed amphotericin B coupled with magnetic nanoparticles was effective against experimental paracoccidioidomycosis, and it did not induce clinical, biochemical or histopathological alterations. The nanocomplex also did not induce genotoxic effects in bone marrow cells. Therefore, it is reasonable to believe that amphotericin B coupled to magnetic nanoparticles and stabilized with bilayer lauric acid is a promising nanotool for the treatment of the experimental paracoccidioidomycosis because it exhibited antifungal activity that was similar to that of free amphotericin B, did not induce adverse effects in therapeutic doses and allowed for a reduction in the number of applications

    Dentro e fuori le Rime. Il polimetro Contento quasi ne’ pensier d’amore

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    Le modalità di trasmissione del polimetro Contento quasi ne’ pensier d’amore suggerisco- no di pensare che il componimento, finora compreso a pieno titolo nel corpus delle liriche di Boccaccio, faccia invece parte di una silloge poetica comprendente anche l’Amorosa visione e la Caccia di Diana, testi insieme ai quali si conserva nella maggior parte dei manoscritti e a cui è legato per affinità formali e di contenuto. Partendo dall’esame della tradizione, il contributo mette a fuoco la fisionomia dei tre testimoni piú importanti del polimetro e ragiona sull’ammissibilità di un’ipotesi avanzata da Branca, e ripresa da Leporatti nell’ultima edizione critica delle Rime boccaccesche, secondo la quale Contento quasi sarebbe un testo concepito con lo scopo di accompagnare i due poemetti

    Boccaccio

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    In Boccaccio le attività di autore, copista, esegeta e traduttore di testi concorrono alla realizzazione di un unico progetto intellettuale. La stessa interpretazione del Decameron – opera fondativa della narrativa europea – non può prescindere dall’esame di questo complesso sistema culturale in cui tradizione e innovazione convivono in una nuova visione del mondo e della letteratura. Il volume propone un profilo di Boccaccio attraverso quindici saggi di studiose (Monica Berté, Roberta Cella, Silvia Finazzi, Irene Iocca, Carla Maria Monti, Laura Regnicoli, Valentina Rovere) e studiosi (Luca Azzetta, Renzo Bragantini, Stefano Carrai, Marco Cursi, Maurizio Fiorilla, Marco Petoletti, Angelo Piacentini, Daniele Piccini) che offrono una rilettura critica delle sue opere, insieme a percorsi dedicati ai documenti biografici, alla lingua dei testi, ai manoscritti autografi e alla biblioteca, agli scambi epistolari con Petrarca e altri corrispondenti, al culto di Dante. Tenendo conto delle prospettive attivate dalla più recente stagione di studi, il libro rilancia la figura di Boccaccio in tutta la sua profondità di autore medievale e di umanista

    Prevention of fistulas after salvage laryngectomy using temporoparietal fascia free flap

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    We conducted a retrospective review to assess the role of the temporoparietalis fascia flap (TPFF), comparing rates of postoperative pharyngocutaneous fistula (PCF) and functional outcomes with those of pectoralis major myocutaneous flap (PMMF) and primary closure of the pharynx, in a population of patients treated with salvage total laryngectomy (STL). Patients were divided in three groups depending on the pharynx reconstruction technique after primary closure: no vascularised tissue augmentation (group 1), PMMF patch (group 2), or TPFF patch (group 3). The main outcomes analysed were overall fistula rate, fistula requiring reoperation and speech and swallowing function at 6 months. Factors influencing the incidence of fistulas were also evaluated. 39 patients respected inclusion criteria: 14, 11 and 14 patients in the three groups, respectively. Nine patients of 39 (23.1%) experienced a PCF. No statistically significant differences were noted between the three groups, except for a longer surgical operation time and a trend for better functional results in group 3. None of the factors analysed significantly influenced the overall rate of fistula. TPFF patch thus represents a reliable alternative to PMMF in preventing PCF in the setting of STL, with minor donor-site morbidity and good functional outcomes
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