1,138 research outputs found

    Cyclooxygenase 2: understanding the pathophysiological role through genetically altered mouse models

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    El pdf del artículo es la versión post-print.Cyclooxygenase (COX) -1 and –2 catalyze the first step in the biosynthesis of prostanoids. COX-1 is constitutively expressed in many tissues and seems to be involved in the house keeping function of prostanoids. COX-2, the inducible isoform, accounts for the elevated production of prostaglandins in response to various inflammatory stimuli, hormones and growth factors. COX-2 expression has been also associated with cell growth regulation, tissue remodelling and carcinogenesis. More of these characteristics have been elucidate through using COX selective inhibitors. Recent advances in transgenic and gene-targeting approaches allow a sophisticated manipulation of the mouse genome by gene addition, gene deletion or gene modifications. The development of COX-2 genetically altered mice has provided models to elucidate the physiological and pathophysiological roles of this enzyme.This work was supported by grants from Instituto de Salud Carlos III (Red de Centros C03/01), Generalitat Valenciana (GRUPOS03/072), Ministerio de Educación y Ciencia (SAF2004-00957) and Comunidad de Madrid (CAM2004-GR/SAL/0388).Peer reviewe

    Формирование профилированных импульсов напряжения для время пролетного спектрометра

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    В работе рассматривается возможность создания время пролетного спектрометра (ВПР) с высокой разрешающей способностью. Работа прибора основана на использовании временной группировки ионов с монотонно растущей энергией, задаваемой в анализирующим элементе ВПР спектрометра. Основная задача получения профилированных импульсов ускоряющего ионы напряжения решается с использованием оригинального формирователя, с включенной параллельно нагрузке предварительно заряженной емкости задающей уровень коррекции напряжения. Проведено моделирование различных модификаций генераторов импульсов. Разработан формирователь с частичным разрядом накопительной емкости и полупроводниковым коммутаторомThe paper considers the possibility of creating a time-of-flight spectrometer with high resolution. The operation of the device is based on the use of a time grouping of ions with a monotonically increasing energy, set in the analyzing element of the spectrometer. The main task of obtaining profiled pulses of ion-accelerating voltage is solved using an original shaper, with a pre-charged capacitance connected in parallel to the load, which sets the level of voltage correction. Various modifications of pulse generators are modeled. A shaper with a partial discharge of the storage capacity and a semiconductor switch has been develope

    Search for supersymmetry in events with b-quark jets and missing transverse energy in pp collisions at 7 TeV

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    Results are presented from a search for physics beyond the standard model based on events with large missing transverse energy, at least three jets, and at least one, two, or three b-quark jets. The study is performed using a sample of proton-proton collision data collected at sqrt(s) = 7 TeV with the CMS detector at the LHC in 2011. The integrated luminosity of the sample is 4.98 inverse femtobarns. The observed number of events is found to be consistent with the standard model expectation, which is evaluated using control samples in the data. The results are used to constrain cross sections for the production of supersymmetric particles decaying to b-quark-enriched final states in the context of simplified model spectra.Comment: Submitted to Physical Review

    Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an