1,009 research outputs found

    Thermal fission cross section measurements of 243Cm and 245Cm

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    A new measurement program was set up at SCK-CEN to determine the thermal neutroninduced fission cross section of a number of Cm isotopes. The experiments are performed at a thermal neutron beam from the graphite moderated reactor BR1 at SCK-CEN. This paper presents preliminary results of our ^243Cm(n,f) and ^245Cm(n,f) cross-section measurements

    Characteristics of light charged particle emission in the ternary fission of 250Cf and 252Cf at different excitation energies

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    The emission probabilities and the energy distributions of tritons, α and ^6He particles emitted in the spontaneous ternary fission (zero excitation energy) of ^250Cf and ^252Cf and in the cold neutron induced fission (excitation energy ≈ 6.5 MeV) of ^249Cf and 251Cf are determined. The particle identification was done with suited ΔE-E telescope detectors, at the IRMM (Geel, Belgium) for the spontaneous fission and at the ILL (Grenoble, France) for the neutron induced fission measurements. Hence particle emission characteristics of the fissioning systems ^250Cf and ^252Cf are obtained at zero and at about 6.5 MeV excitation energies. While the triton emission probability is hardly influenced by the excitation energy, the ^4He and ^6He emission probability in spontaneous fission is higher than for neutron induced fission. This can be explained by the strong influence of the cluster preformation probability on the ternary particle emission probability

    Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development

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    Background: In this study we exploit the unique genome organization of ciliates to characterize the biological function of histone modification patterns and chromatin plasticity for the processing of specific DNA sequences during a nuclear differentiation process. Ciliates are single-cell eukaryotes containing two morphologically and functionally specialized types of nuclei, the somatic macronucleus and the germline micronucleus. In the course of sexual reproduction a new macronucleus develops from a micronuclear derivative. During this process specific DNA sequences are eliminated from the genome, while sequences that will be transcribed in the mature macronucleus are retained. Results: We show by immunofluorescence microscopy, Western analyses and chromatin immunoprecipitation (ChIP) experiments that each nuclear type establishes its specific histone modification signature. Our analyses reveal that the early macronuclear anlage adopts a permissive chromatin state immediately after the fusion of two heterochromatic germline micronuclei. As macronuclear development progresses, repressive histone modifications that specify sequences to be eliminated are introduced de novo. ChIP analyses demonstrate that permissive histone modifications are associated with sequences that will be retained in the new macronucleus. Furthermore, our data support the hypothesis that a PIWI-family protein is involved in a transnuclear cross-talk and in the RNAi-dependent control of developmental chromatin reorganization. Conclusion: Based on these data we present a comprehensive analysis of the spatial and temporal pattern of histone modifications during this nuclear differentiation process. Results obtained in this study may also be relevant for our understanding of chromatin plasticity during metazoan embryogenesis

    Reconstruction of the acetabulum in THA using femoral head autografts in developmental dysplasia of the hip

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    <p>Abstract</p> <p>Background</p> <p>Severe acetabular deficiencies in cases of developmental dysplasia of the hip (DDH) often require complex reconstructive procedures in total hip arthroplasty (THA). The use of autologous femoral head grafts for acetabular reconstruction has been described, but few data is available about clinical results, the rates of non-union or aseptic loosening of acetabular components.</p> <p>Methods</p> <p>In a retrospective approach, 101 patients with 118 THA requiring autologous femoral head grafts to the acetabulum because of DDH were included. Six patients had died, another 6 were lost to follow-up, and 104 hips were available for clinical and radiological evaluation at a mean of 68 ± 15 (13 to 159) months.</p> <p>Results</p> <p>The average Merle d'Aubigné hip score improved from 9 to 16 points. Seven implants had to be revised due to aseptic loosening (6.7%). The revisions were performed 90 ± 34 (56 to 159) months after implantation. The other hips showed a stable position of the sockets without any signs of bony non-union, severe radiolucencies at the implant-graft interface or significant resorption of the graft.</p> <p>Conclusion</p> <p>The use of autologous femoral head grafts with cementless cups in primary THA can achieve promising short- to midterm results in patients with dysplastic hips.</p

    Effect of the unpolarized spin state in spin-correlation measurement of two protons produced in the 12C(d,2He) reaction

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    In this note we discuss the effect of the unpolarized state in the spin-correlation measurement of the 1S0^1S_0 two-proton state produced in 12C(d,2He) reaction at the KVI, Groningen. We show that in the presence of the unpolarized state the maximal violation of the CHSH-Bell inequality is lower than the classical limit if the purity of the state is less than 70% \sim \verb+70%+. In particular, for the KVI experiment the violation of the CHSH-Bell inequality should be corrected by a factor 10%\sim\verb+10%+ from the pure 1S0^1S_0 state.Comment: 6 pages, to appear in J. Phys.

    Fostering European Collaborations: EUFRAT and work done at the accelerator facilities of JRC-IRMM

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    The European Commission via the General Directorate RTD in its different Framework Programs supported collaborations of member state institutions dealing with nuclear data. The projects EFNUDAT, ERINDA, CHANDA and EUFRAT all have in common Transnational Access Activities (TAA) to partner institutions. Within the past 10 years the collaborations have grown and in CHANDA now 35 partners are involved of which 16 offer TAA to their facilities. Since June 2014 JRC-IRMM, one of the driving forces behind the TAA, launched its own TAA project EUFRAT to foster collaborations with member states institutions. The calls for proposals are open ended with a deadline twice a year. A Project Advisory Committee discusses the proposals and decides on about approval. Financial support is given to approved proposals for two scientists. So far two calls have been evaluated with a request for access totalling more than 5000 h. Examples of proposals at the accelerator facilities at the JRC-IRMM are presented showing the multitude of possibilities using the nuclear facilities at the JRC-IRMM

    A response surface model approach for continuous measures of hypnotic and analgesic effect during sevoflurane-remifentanil interaction: quantifying the pharmacodynamic shift evoked by stimulation

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    Background: The authors studied the interaction between sevoflurane and remifentanil on bispectral index (BIS), state entropy (SE), response entropy (RE), Composite Variability Index, and Surgical Pleth Index, by using a response surface methodology. The authors also studied the influence of stimulation on this interaction. Methods: Forty patients received combined concentrations of remifentanil (0 to 12 ng/ml) and sevoflurane (0.5 to 3.5 vol%) according to a crisscross design (160 concentration pairs). During pseudo–steady-state anesthesia, the pharmacodynamic measures were obtained before and after a series of noxious and nonnoxious stimulations. For the “prestimulation” and “poststimulation” BIS, SE, RE, Composite Variability Index, and Surgical Pleth Index, interaction models were applied to find the best fit, by using NONMEM 7.2.0. (Icon Development Solutions, Hanover, MD). Results: The authors found an additive interaction between sevoflurane and remifentanil on BIS, SE, and RE. For Composite Variability Index, a moderate synergism was found. The comparison of pre- and poststimulation data revealed a shift of C50SEVO for BIS, SE, and RE, with a consistent increase of 0.3 vol%. The Surgical Pleth Index data did not result in plausible parameter estimates, neither before nor after stimulation. Conclusions: By combining pre- and poststimulation data, interaction models for BIS, SE, and RE demonstrate a consistent influence of “stimulation” on the pharmacodynamic relationship between sevoflurane and remifentanil. Significant population variability exists for Composite Variability Index and Surgical Pleth Index
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