6 research outputs found

    Gestational Exposure to Ambient Particulate Matter Alters Neonatal Cytokines

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    The role of maternal exposure to fine particulate matter (PM2.5) in the development of the fetal immune system remains unclear. A total of 482 mother–infant pairs were included in our longitudinal birth cohort study. Maternal PM2.5 exposure during the first trimester was assessed, and 27 neonatal cytokines were detected. This study was designed to evaluate the effects of maternal PM2.5 exposure on fetal immune system development and to identify the most heavily weighted component. Negative associations were observed between maternal PM2.5 exposure and neonatal IL7 [β = −0.05; 95% confidence interval (CI), (−0.07, −0.03); p < 0.001], IL12 [β = −0.04; 95% CI, (−0.06, −0.01); p = 0.05], and IL13 [β = −0.04; 95% CI, (−0.06, −0.02); p = 0.02], while positive associations with neonatal Eotaxin [β = 0.17; 95% CI, (0.09, 0.25); p < 0.001], PDGFbb [β = 0.15; 95% CI, (0.07, 0.23); p = 0.01], MIP1b [β = 0.10; 95% CI, (0.05, 0.15); p p < 0.001]. The most heavily weighted component in the three interleukin models was consistently BC (weighted 0.95 for IL7, 0.85 for IL12, and 0.88 for IL13), NH4+ for two chemokines (weighted 0.47 for Eotaxin and 0.32 for RANTES), and SO42– for PDGFbb (0.43) and MIP1b (0.42). Gestational exposure to PM2.5 could alter neonatal cytokine levels, and special attention should be paid to certain components

    List of SNPs with observed association p-value being less than 1.00E-05.

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    <p>Chromosomal position is specified in Build 36 (hg18). OR refers to odds ratio and 95%CI refers to 95% confidence interval. <i>TRIM36</i> refers to tripartite motif containing 36 gene. <i>ZBTB16</i> refers to zinc finger and BTB domain containing 16 gene.</p><p>List of SNPs with observed association p-value being less than 1.00E-05.</p

    Protein-protein interaction network build from proteins encoded in associated intervals.

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    <p>The colored, full circles represent proteins encoded in associated intervals (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0122501#pone.0122501.s002" target="_blank">S2 Table</a>). The smaller, grey circles represent interactors of indirect connections. Functionally, the DAPPLE-constructed diagram can be divided into two main groups: group “A” mostly involved in the regulation of gene expression and inflammation; and group “B” mostly involved in cell adhesion.</p

    Results of protein-protein link evaluation in DAPPLE. List of indirect interactors.

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    <p>Presented p-values reflect the probability that by chance individual interactors would be as connected to seed proteins (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0122501#pone.0122501.s002" target="_blank">S2 Table</a>) as was observed in the constructed network.</p><p>Results of protein-protein link evaluation in DAPPLE. List of indirect interactors.</p