2,672 research outputs found

    Temporal Negative Priming: Visual and Auditory

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    Recently Kahan, Slowiaczek, and Altschuler (2017) reported a new form of negative priming, termed temporal negative priming. The purpose of the current study was to first replicate this effect using a slightly altered methodology and then to examine possible mechanisms that contribute to temporal negative priming and the extent to which this effect might generalize across modalities. By requiring participants to attend to both the distractor and target stimuli, the first experiment found robust temporal negative priming effects. The second study explored whether temporal negative priming is in part caused by difficulty binding features of a target with a temporal position that was previously associated with features of a distractor (Park & Kanwisher, 1994). Results were inconclusive but are consistent with the possibility that feature mismatch theory may not be the causal mechanism behind this effect. In addition, the data support memory-based over inhibition-based theories, but additional research is needed to determine if this memory-based negative priming effect is sensitive to manipulations which affect memory retrieval. The final study found temporal negative priming within the auditory modality as well. Fifty-seven individuals participated in the first experiment, 49 individuals participated in the second experiment and 38 individuals participated in the final experiment. Similar to other negative priming studies, participants were shown prime-probe trial pairs. However, in all of the studies reported here, prime-probe trial pairs were shown at different timing sequences to help separate the effects of temporal location and response

    Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions

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    A recent workshop titled ‚ÄúDeveloping Models to Study Polymicrobial Infections,‚ÄĚ sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 351 investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem. The frameworks proposed here, we believe, could be generally useful in developing new model systems for other infectious diseases. Developing and validating new approaches to study the complex polymicrobial communities in the CF airway could open windows to new therapeutics to treat these recalcitrant infections, as well as uncovering organizing principles applicable to chronic polymicrobial infections more generally

    Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

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    The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal

    Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in ‚ąös=13‚ÄČTeV pp collisions with the ATLAS detector