11 research outputs found

    Modulating Neuro-Endocrine Effects Of Bioactive Water Naftussya From Layers Truskavets’ And Pomyarky At Humans With Dysfunction Of Neuro-Endocrine-Immune Complex

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    Background. Previously we have been carry out comparative investigation long-term effects of Bioactive Water Naftussya from layers Truskavets’, Pomyarky and Skhidnyts’a on some metabolic and biophysical parameters at men with dysfunction of neuro-endocrine-immune complex. The aim of this study is the investigation long-term effects on neuro-endocrine regulation at similar patients. Materials and methods. The object of observation were 20 volunteers: ten women and ten men aged 33-76 years without clinical diagnose but with dysfunction of neuro-endocrine-immune complex and metabolism. We evaluated the trait and reactive anxiety, recorded EEG, HRV and blood pressure, determined levels of Cortisol, Aldosterone, Testosterone, Triiodothyronine and Calcitonin. After examination volunteers within 7 days used bioactive water Naftussya (250 mL three times a day) from Truskavets’ or Pomyarky layer, then repeated the tests listed. Results. Weekly drinking of Bioactive Water Naftussya normalizes initially elevated levels of testosterone in women and reduces initially normal its level in men, in both sexes normalizes initially elevated levels of triiodothyronine and activity of the autonomic regulatory systems as the parasympathetic, so sympathetic, combined with a slight increase in the normal levels of aldosterone and trend to increase (under low) reactive anxiety as well as post occlusive reactivity of vascular tone. Among the 164 registered parameters quantitative EEG revealed noticeable changes only 8. This is, above all, normalizing increase initially reduced spectral power density (SPD) α-rhythm in loci T6 by 93%, P4 by 33%, F7 by 29%, increase by 10% in the normal range modal frequency of β-rhythm and further enhance SPD θ-rhythm in locus T5 by 42%. On the other hand, showed a reduction by 28% initially normal PSD of β-rhythm in locus in O2 and further reduction its by 20% in locus P4. Moreover, there was left-sided lateralization initially symmetric α-rhythm. No significant differences between the effects of Naftussya both deposits were found. Conclusion. Bioactive water Naftussya both Truskavets’ and Pomyarky layers causes favorable normalizing effects on abnormalities neuro-endocrine parameters, which is a manifestation of its adaptogenic properties

    Cluster analysis of uric acid exchange parameters in female rats

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    Background. Uric acid is traditionally considered as the final product of human and primate DNA/RNA degradation, devoid ofuseful physiological activity. However, there is an opinion that theuric acid molecule, by analogy with methylxanthines (caffeine, theophylin, theobromine) has physiological activity. The acquired experience allows us to offer a topic for future research: “Neurotropic and immunotropic activity of endogenous uric acid”. Working hypothesis. Uric acid, interacting with A1 and A2a adenosine receptors as well as phosphodiesterase and Na,K-ATPase of neurons, modulates the activity of nerve centers, which in turn modulate immunocytes. Perhaps the direct effect of uric acid on immunocytes, since the existence oftheophylline-resistant and theophylline-sensitive subpopulations of T-lymphocytes has long been known. The proposed article is the first swallow of the announced project.Material and Methods. Experiment was performed on 58 healthy female Wistar rats 220-300 g. Among them 10 animals remained intact, using tap water from drinking ad libitum. The rats of others groups for 6 days administered through the tube various fluids at a dose of 1,5 mL/100 g of body mass.The day after the completion of the drinking course the plasma and urine levels of the uric acid (uricase method) were determined. Results. We obtained a wide range of uric acid metabolism parameters, divided into four clusters, quantitatively and qualitatively different from each other. On the basis of the accepted criteria, 29,3% of animals state normouricemia in combination with normal or slightly increased excretion of uric acid. In 24,1% of rats, hypouricemia is combined with normal or slightly reduced uricosuria. In 31,0% of animals normal or slightly elevated levels of plasma uric acid are accompanied by a very marked dispersion of uricosuria. The remaining 15,5% of rats expressed hyperuricemia combined with normal or slightly increased uricosuria. In the following articles, functional relationships of uricemia and uricosuria with the parameters of autonomic regulation, immunity and metabolism will be analyzed

    Interrelations between changes in parameters of HRV, EEG and phagocytosis at patients with chronic pyelonephritis and cholecystitis

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    Background. Previously we have shown within the immunological homunculus conception that take place causal relationships between induced by balneotherapy changes in parameters of EEG and HRV, on the one hand, and the parameters of humoral and cellular immunity, on the other hand. The purpose of this study is to find out the relationships between induced by balneotherapy changes in parameters of EEG and HRV, on the one hand, and the parameters of phagocytosis , on the other hand. Material and methods. In basal conditions in 33 men and 10 women with chronic pyelonephritis and cholecystitis in remission, we recorded twice, before and after balneotherapy at the spa Truskavets’, EEG (“NeuroCom Standard”) and HRV (“Cardiolab+VSR”). In blood estimated parameters of phagocytic function of neutrophils against Staphylococcus aureus and Escherichia coli. Results. Judging by the coefficients of canonical correlation, the maximal subordinate nervous regulation is the completeness of phagocytosis of E. coli (R=0,944), whereas the influence of the nervous system on the completeness of phagocytosis Staph. aur. is minimal (R=0,607). With regard to the intensity of phagocytosis, the differences in the strength of nerve influence are expressed less (0,893 vs 0,744), and in relation to the activity of phagocytosis as well as the bactericidal ability of neutrophils, there are no differences between R (0,858 vs 0,857 and 0,831 vs 0,834, respectively). However, significant differences were found between profiles of correlation coefficients between EEG and HRV parameters, on the one hand, and phagocytosis parameters, on the other hand, for representatives of Gram-negative and Gram-positive microbes. Conclusion. In the nervous regulation of phagocytosis by neutrophils of the Gram-negative and Gram-positive microbes are involved the structures that are localized in different parts of the CNS

    Mineral waters, metabolism, neuro-endocrine-immune complex, s. 252.

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    Dedicated to the 75th anniversary of Volodymyr Illich Kozyavkin with gratitude for the support of the Truskavetsian Scientific School of BalneologyThe monograph systematizes these writers and highlights the results of their own priority experimental and clinical-physiological studies of the impact of drinking mineral waters of Ukraine on neuroendocrine regulation, metabolism and immunity of healthy rats and patients in the process of rehabilitation of chronic pyelonephritis and cholecystitis in remission. In line with the concepts of functional-metabolic continuum and neuroendocrine-immune complex using the methods of factor, discriminant and canonical correlation analysis, it is demonstrated that mineral waters have both similar and specific physiologically favorable modulating effects on the parameters of the studied body systems. For specialists in medical rehabilitation, endocrinologists, immunologists, biochemists, pathophysiologists

    Gas Discharge Visualization (Electrophotonic Imaging, Kirlianography). Theoretical and Applied Aspects, 189 s.

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    The monograph highlights the results of priority clinical-physiological studies of the relationships between gas discharge visualization (electrophotonic imaging, kirlianography) parameters, on the one hand, and electroencephalograms, heart rate variability, immunograms, phagocytosis, the content of the main adaptation hormones (cortisol, aldosterone, testosterone, triiodothyronine, calcitonin) in the blood as well as acupuncture points - on the other hand. It is shown that the GDV/EPI method reliably reflects the state of the body's neuro-endocrine-immune complex as well as others parameters and has the right to take its place in the arsenal of physiological/biophysical methods. For biophysicists, physiologists, psychophysiologists, endocrinologists, immunologists, medical rehabilitation specialists. INTRODUCTION Advances in biophysics, biology, functional genomics, neuroscience, psychology, psychoneuroimmunology, and other fields suggest the existence of a subtle system of “biofield” interactions that organize biological processes from the subatomic, atomic, molecular, cellular, and organismic to the interpersonal and cosmic levels. Biofield interactions may bring about regulation of biochemical, cellular, and neurological processes through means related to electromagnetism, quantum fields, and perhaps other means of modulating biological activity and information flow. The biofield paradigm, in contrast to a reductionist, chemistry-centered viewpoint, emphasizes the informational content of biological processes; biofield interactions are thought to operate in part via low-energy or “subtle” processes such as weak, nonthermal electromagnetic fields (EMFs) or processes potentially related to consciousness and nonlocality. Biofield interactions may also operate through or be reflected in more well-understood informational processes found in EEG and ECG data. Recent advances have led to the development of a wide variety of therapeutic and diagnostic biofield devices, defined as physical instruments best understood from the viewpoint of a biofield paradigm [Muehsam D et al, 2015]. Biofield devices comprise physical instruments that may be most clearly understood from the viewpoint of a biofield paradigm, and a large and diverse number of devices have been developed to measure or manipulate biofield interactions. These include both diagnostic devices (to measure biofield properties) and therapeutic devices (to manipulate biofield interactions). The study of biofield devices is at a nascent stage of development, and much further research is needed to determine clinical efficacy and elucidate the underlying mechanisms of action for many of the devices mentioned here. The biofield devices operate through a variety of modalities rather than a single mechanism. Some biofield devices function through well-understood mechanisms and are already widely used in clinical settings: for example, electroencephalography (EEG)- and electrocardiography (ECG)-based heart rate variability (HRV). Other devices appear to operate through mechanisms that are novel or incompletely understood. However, all of these devices share a common property: rather than functioning primarily in a reductionist, chemistry-centered manner, biofield devices function via the informational content of biological processes and can interact via low-energy or “subtle” processes, including those potentially related to consciousness and nonlocality [Muehsam D et al, 2015]. Here Muehsam D et al [2015] provide a brief overview of the broad categories of biofield devices, with the goal being to stimulate further discussion and research. Authors describe those devices for which thay deemed that sufficient evidence exists to warrant mention. They chose to focus upon devices for which peer-reviewed scientific reports suggesting efficacy are available rather than conference proceedings or manufacturers' white papers. However, in the few cases that specific devices with sufficient promise and relevance lacked a peer-reviewed basis, authors have presented whatever evidence was available. Here, devices are organized according to mode of operation and these modalities include electromagnetic field (EMF)-light, EMF-heat, EMF-nonthermal, electrical current, vibration and sound, physical and mechanical, intentionality and nonlocality, gas and plasma, and other (mode of operation not well understood). Muehsam D et al [2015] deemed that gas discharge visualization (GDV) is an important example of the use of plasma in biofield science. Back in 1880 Nikola Tesla demonstrated that when placing the man in the high-frequency field around the body there is a bright glow [cit. by Korotkov KG, 2001]. In 1892 Nardkevych-Yodko YO recorded glow human hands on photographic plate [cit. by Ciesielska I, 2009]. However, a well-known method of "high-frequency photography" was due to spouses Kirlian SD&VH who in 1939 independently discovered this phenomenon [Kirlian SD & Kirlian VKh, 1961], later called "Kirlian’s effect". This technique has been called corona discharge photography [Boyers DG & Tiller WA, 1973], electrophotography [Earle L, 1975], electrography [Konikiewicz LW, 1979], GDV [Bankovskii NG et al, 1986]. In 1996 Korotkov KG created a new scientific approach, based on the digital videotechnics, modern electronics and computer processing quantitative data, called as method gas discharge visualization (GDV bioelectrography). Parallel uses the terms Kirlianography and Electrophotonic imaging (EPI) [Korotkov KG, 2001; 2007; 2014; Korotkov KG et al, 2002; Wisneski LA & Anderson L, 2009; Jakovleva E & Korotkov K, 2013]. Method of GDV, essence of which consists in registration of photoelectronic emission of skin, induced by high-frequency electromagnetic impulses, allows to estimate integrated psycho-somatic state of organism. The first base parameter of GDV is Area of Gas Discharge Image (GDI) in Right, Frontal and Left projections registered both with and without polyethylene filter. The second base parameter is a coefficient of form/shape (ratio of square of length of external contour of GDI toward his area), which characterizes the measure of serration/fractality of external contour. The third base parameter of GDI is Entropy, id est measure of chaos. It is considered that GDI, taken off without filter, characterizes the functional changes of organism, and with a filter characterizes organic changes. Program estimates also Energy and Asymmetry of virtual Chakras [Korotkov KG, 2001; 2007; 2014]. Nearly 1000 papers have been published (mostly in Russian) on GDV research and a few hundred more in the West. These intriguing data suggest that informatics based upon biofield measurement devices such as the GDV may be useful for gaining deeper understanding of disease states and guiding practitioners and their patients towards states of greater wellness [Muehsam D et al, 2015]. Without regard to the wideuse enough of method in medicine, psychology, valeology and others like that, he yields to the just criticizing for an insufficient physiology ground. There fore we put before itself sweep to analyse relationships between the parameters of GDV - from one side, and by the row of neurodynamics, endocrine, immune. psychophysiological, and other parameters - on the other hand

    Similarity Of Effects On EEG Parameters Of Aramaic, Greek Catholic And Krishnaic Prayers

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    The neurotropic effects of Prayer are manifested in two inhibitory and three activating patterns. The first inhibitory pattern reflects the decrease in elevated and upper limit levels of SPD of θ-and δ-rhythm in frontal loci and the second - decrease in normal SPD levels of β-and θ-rhythm in the frontal, central, temporal and parietal loci. The first activating pattern reflects a small increase in normal levels of β-rhythm index and asymmetry and SPD entropy in locus C3, as well as a further increase in elevated δ-rhythm SPD levels in loci P3 and T3. The second pattern reflects the slight increase in normal SPD levels of θ-rhythm in loci T3, T5, T6, O2 and α-rhythm in locus T5, as well as their indices and entropy SPD in locus O2. The third pattern reflects a slight increase in amplitude and SPD of α-rhythm in central, frontal, temporal and occipital loci

    Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 3. Correlations between parameters EEG, HRV and immunogram

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    Kul’chyns’kyi Andriy B, Gozhenko Anatoliy I, Zukow Walery, Popovych Igor L. Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 3. Correlations between parameters EEG, HRV and immunogram. Journal of Education, Health and Sport. 2017;7(3):53-71. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.265228 http://ojs.ukw.edu.pl/index.php/johs/article/view/4209 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.01.2017. Revised 21.01.2017. Accepted: 31.01.2017. NEURO-IMMUNE RELATIONSHIPS AT PATIENTS WITH CHRONIC PYELONEPHRITE AND CHOLECYSTITE. Communication 3. CORRELATIONS BETWEEN PARAMETERS EEG, HRV AND IMMUNOGRAM Andriy B Kul’chyns’kyi1, Anatoliy I Gozhenko2, Walery Zukow3, Igor L Popovych4 1Communal Hospital, Truskavets’, Ukraine [email protected] 2Ukrainian Scientific Research Institute of Transport Medicine Ministry of Health, Odesa [email protected] 3Faculty of Physical Education, Health and Tourism, Kazimierz Wielki University, Bydgoszcz, Poland [email protected] 4Department of Immunophysiology, OO Bohomolets’ Institute of Physiology, Kyiv, Ukraine [email protected] Abstracts Background. The immunological homunculus conception considers somatotopic organization to СNS regulation of immune system. We set a goal to analyze the causal relationships between parameters of EEG and HRV, on the one hand, and the parameters of immunity, on the other hand. Methods. In basal conditions in 23 men with chronic pyelonephrite and cholecystite in remission, we recorded EEG (“NeuroCom Standard”) and HRV (“Cardiolab+VSR”). In blood estimated routine parameters of Immunity on a set of I and II levels recommended by the WHO. Results. Maximal coefficient canonical correlation (R) parameters of EEG and HRV detected with relative level CD22+ B-Lymphocytes: 0,94 (p<10-4), maximal relationships take place with Spectral Power Density (SPD) absolute (a) Fp1-α (r=-0,64) and relative (r) PSD Fp1-β (r=0,60). R with serum level IgM takes 0,90 (p<10-4), maximal relationships with rSPD O1-θ (r=0,60) and rHF HRV (r=0,52), with serum level IgG takes 0,86 (p<10-3), maximum with rSPD of β-rhythm in loci T6, O1 and O2 (r for all makes 0,40), with serum level IgA takes 0,84 (p<10-4), maximum with Asymmetry of δ-rhythm (r=0,59) and aSPD T4-θ (r=-0,50) as well as with Circulating Immune Complexes: R=0,84 (p<10-4), maximum with Bayevskiy’s Stress Index HRV (r=0,45) and rSPD T3-α (r=0,39). R with relative level CD8+ T-Lymphocytes makes 0,81 (p<10-4), maximal relationships take place with aSPD of α-rhythm in loci P4 (r=-0,38) and P3 (r=-0,31) as well as with rVLF HRV (r=-0,29). R with relative level CD4+ T-Lymphocytes makes 0,79 (p<10-3), maximum with aSPD of β-rhythm in loci F4 (r=0,40) and T3 (r=0,39). R with level CD16+ NK-Lymphocytes makes 0,71 (p=0,009), maximal relationships take place with Index of α-rhythm (r=-0,36) and Entropy SPD in locus C3. Minimal R detected with level “active” T-Lymphocytes: 0,57 (p=0,029). Conclusion. Take place neuro-immune causal relationships in bounds of immunological homunculus conception. Keywords: HRV, EEG, T-, NK-, B-Lymphocytes, Immunoglobulines M,G,A, Circulating immune complexes, correlations

    EFFECT OF XENON ON THE STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF THE INTERNAL ORGANS OF RATS WITH DIFFERENT FORMS OF PERITONITIS

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    Gozhenko A. I., Vasil’ev A. A., Sirman V. M., Nasibullin B. A. Влияние ксенона на структурно-функциональные характеристики внутренних органов крыс с разными формами перитонита = Effect of xenon on the structural and functional characteristics of the internal organs of rats with different forms of peritonitis. Journal of Education, Health and Sport. 2015;5(5):531-537. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.35658 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%285%29%3A531-537 http://pbn.nauka.gov.pl/works/684420 Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive   Deklaracja. Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie. Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r. The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014). © The Author (s) 2015; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 10.04.2015. Revised 15.05.2015. Accepted: 31.05.2015.   Влияние ксенона на структурно-функциональные характеристики внутренних органов крыс с разными формами перитонита   Effect of xenon on the structural and functional characteristics of the internal organs of rats with different forms of peritonitis   А. И. Гоженко, А. А. Васильев, В. М. Сирман, Б. А. Насибуллин A. I. Gozhenko, A. A. Vasil’ev, V. M. Sirman, B. A. Nasibullin   ГП “Украинский НИИ медицины транспорта МОЗ Украины”, Одесса SE "Ukrainian Scientific Research Institute of Transport Medicine, Ministry of Health of Ukraine", Odessa   Summary There was an experiment on the 177 Wistar rats of outbreed rarefaction. The authors were modelling fecal (infectious) peritonitis and traumatic (gunshot) peritonitis. A physiological solution lavage of abdominal cavity saturated with xenon was used as a corrective procedure. The authors stated the positive effect on the enlargement of pathologic process. The positive effect was expressed by depression of intensity and duration of phlogistic changes. In case of traumatic peritonitis (delay of physiological process is typical for it) it is stated the cutting of this time, so all the time of physiological process is cut. Key words: peritonitis, xenon, abdominal cavity organs.   Резюме Авторы по результатам исследования 177 крыс линии Вистар аутобредного разведения, у которых моделировали каловый (инфекционный) перитонит и травматический (огнестрельный) перитонит выявили, что промывание брюшной полости физиологическим раствором обогащенным ксеноном оказывает положительное влияние на развитие патологического процесса. Положительное влияние состоит в уменьшении выраженности и продолжительности воспалительных изменений. В случае травматического перитонита, для которого характерна отсроченность физиологического процесса, отмечается сокращение этого времени, т.е. сокращается всё время патологического процесса. Ключевые слова: перитонит, ксенон, органы брюшной полости

    Features of metabolic reactions to various water-salt loads in female rats

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    Background. In the previous article we reported that screening registered parameters of water-salt, nitrous and lipid metabolism as well as the neuroendocrine-immune complex found 42 among them who in rats subjected to various water-salt loads, significantly different from that of intact rats, but on average the same group of animals that received liquids with different mineralization and chemical composition. The purpose of this article is to find out the features of the reactions of the parameters of metabolism. Materials and methods. Experiment was performed on 58 healthy female Wistar rats 240-290 g divided into 6 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Instead, the other rats received the same tap water as well as waters Sophiya, Naftussya, Gertsa and its artificial salt analogue through the probe at a dose of 1,5 mL/100 g of body mass for 6 days. The day after the completion of the drinking course in all rats the parameters of water-salt, nitrous and lipid metabolism were registered. Results. Found that 16 metabolic parameters the maximum deviates from the level of intact rats under the influence of the salt analogue of Gertsa water, a smaller, but tangible effect is made by the Gertsa native water, even less effective waters Sofiya and Naftussya, instead of ordinary water is almost ineffective in relation to these metabolic parameters. The other 19 parameters deviates to a maximum extent from the reference level after the use of water Naftussya, fresh water is less effective, whereas quasi-isotonic liquids are practically inactive for these parameters. The remaining 13 parameters in animals that use normal water, deviates from intact control to the same extent as in the previous pattern, which, apparently, is also due to the stressful effects of the load course. Both Naftussya and Gertsa water and its salt analogue prevent the stress deviations of these parameters. Instead, by consumption of water Sofiya stresses deviations of these parameters is reversed. The method of discriminant analysis revealed 33 variables (among them 8 refer to plasma/erythrocytes electrolytes, 7 to electrolytes of urine, to other metabolic parameters of plasma 5 and urine 9, as well as glomerular filtration, canalicular reabsorption, diurese and urine osmolarity), the totality of which the metabolic reactions to various water-salt loads are identified (recognized) with an accuracy of 98,3%. Conclusion. The features of the reactions of the parameters of metabolism are due to the content in waters NaCl, SO42- as well as organic carbon and nitrogen

    Features of immunity by various constellations of principal adaptation hormones and autonomous regulation in practically healthy people

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    Gozhenko Anatoliy I, Hrytsak Yaroslav L, Barylyak Liliya G, Kovbasnyuk Marta M, Tkachuk Svitlana P, Korolyshyn Tetyana A, Matiyishyn Galyna Yo, Zukow Walery, Popovych Igor L. Features of immunity by various constellations of principal adaptation hormones and autonomous regulation in practically healthy people. Journal of Education, Health and Sport. 2016;6(10):215-235. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.160979 http://ojs.ukw.edu.pl/index.php/johs/article/view/3936         The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.10.2016. Revised 02.10.2016. Accepted: 15.10.2016.       FEATURES OF IMMUNITY BY VARIOUS CONSTELLATIONS OF PRINCIPAL ADAPTATION HORMONES AND AUTONOMOUS REGULATION IN PRACTICALLY HEALTHY PEOPLE   Anatoliy I Gozhenko1, Yaroslav L Hrytsak2, Liliya G Barylyak2,3,4, Marta M Kovbasnyuk4, Svitlana P Tkachuk3, Tetyana A Korolyshyn4, Galyna Yo Matiyishyn3, Walery Zukow5, Igor L Popovych4   1Ukrainian Scientific Research Institute of Transport Medicine Ministry of Health, Odesa   [email protected] 2Hotel Spa Complex “Karpaty”, Truskavets’, Ukraine  [email protected] 3JSC “Truskavets’kurort”, Truskavets’, Ukraine   [email protected] 4Laboratory of Experimental Balneology, OO Bogomoletz Institute of Physiology NAS, Kyiv, Ukraine  [email protected];   [email protected] 5Faculty of Physical Education, Health and Tourism, Kazimierz Wielki University, Bydgoszcz, Poland  [email protected]   Abstracts Background. It is known that in practically healthy (without clinical diagnose) people constellations of principal Adaptation Hormones displays widely variability representing different gradations of health and premorbide states. Previously, we found at least four mutually separated groups of people (endocrine clusters). The aim of this study is to elucidate the characteristics of immunity in members of different neuroendocrine clusters. Material and research methods. We determined twice in ten women and ten men aged 33-76 years without clinical diagnose serum levels of Cortisol, Aldosterone, Triiodothyronine, Testosterone and Calcitonin (ELISA) as well as Bayevskiy’s Stress Index by HRV as markers of General Adaptation Reactions (GAR). Also used determined by Leukocytogram Popovych’s Strain and Adaptation Indices. Immune status evaluated on a set of I and II levels recommended by the WHO. Results. All 40 case was distributed among four neuroendocrine clusters. Cluster N1 contains 10% cases with drastically hypercortisolemia and increased Baevskiy’s Stress Index combined with moderately decreased level of Testosterone but normal levels of Triiodothyronine, Aldosterone and Calcitonin. It is accompanied by a significant supression of cellular immunity and insignificant activation of humoral immunity. 12,5% cases (Cluster N2) characterized moderately increased level of Cortisol and Triiodothyronine combined with moderately decreased level of Calcitonin but normal levels of Testosterone and Aldosterone. Despite the normal average level of Stress Index it ranges in a wide range. This is accompanied by negligible inhibition of cellular immunity and significant activation of humoral immunity. 32,5% cases (Cluster N3) characterized moderately increased level of Cortisol too while moderately decreased level of Triiodothyronine as well as Calcitonin and Testosterone combined with upper borderline level of Aldosterone and normal level of Stress Index. This is accompanied by a significant activation of humoral immunity without abnormalities of cellular immunity. In 45% cases (Cluster N4) neuro-hormonal costellation characterized upper borderline levels of Cortisol as well as Testosterone combined with normal levels others hormones and even slightly reduced level of Stress Index. This is accompanied by more pronounced activation of humoral immunity without abnormalities of cellular immunity. Conclusion. Various constellations of Neuroendocrine factors of General Adaptation Reactions accompanied by various constellations parameters of Immunity. Keywords: Cortisol, Aldosterone, Triiodothyronine, Testosterone, Calcitonin, HRV, Immunity, Relationships
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