730 research outputs found

    Two populations of transition discs?

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    We examine the distribution of transition discs as a function of mm flux. We confirm that as expected in any model in which most primordial discs turn into transition discs and in which mm flux declines with time, transition discs have lower mm fluxes on average than primordial discs. However, we find that the incidence of transition discs does not, as expected, fall monotonically towards large mm fluxes and we investigate the hypothesis that these mm bright transition discs may have a distinct physical origin. We find that mm bright transition discs occupy a separate region of parameter space. Transition discs in the bright mm sub-sample have systematically higher accretion rates and inner hole radii than those in the faint mm sub-sample, along with being systematically weighted to earlier spectral types.Comment: 5 pages, 5 figures, accepted version: mnras letter

    Graphene Bioelectronic Nose for the Detection of Odorants with Human Olfactory Receptor 2AG1

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    A real-time sensor for the detection of amyl butyrate (AB) utilising human olfactory receptor 2AG1 (OR2AG1), a G-protein coupled receptor (GPCR) consisting of seven transmembrane domains, immobilized onto a graphene resistor is demonstrated. Using CVD graphene as the sensor platform, allows greater potential for more sensitive detection than similar sensors based on carbon nanotubes, gold or graphene oxide platforms. A specific graphene resistor sensor was fabricated and modified via non-covalent π–π stacking of 1,5 diaminonaphthalene (DAN) onto the graphene channel, and subsequent anchoring of the OR2AG1 receptor to the DAN molecule using glutaraldehyde coupling. Binding between the target odorant, amyl butyrate, and the OR2AG1 receptor protein generated a change in resistance of the graphene resistor sensor. The functionalized graphene resistor sensors exhibited a linear sensor response between 0.1–500 pM and high selectively towards amyl butyrate, with a sensitivity as low as 500 fM, whilst control measurements using non-specific esters, produced a negligible sensor response. The approach described here provides an alternative sensing platform that can be used in bioelectronic nose applications

    Concern About Petrochemical Health Risk Before and After a Refinery Explosion

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    On March 23, 2005, a large explosion at an oil refinery in Texas City, Texas caused 15 deaths and approximately 170 injuries. Little is known about how such an industrial accident influences concern about environmental health risks. We used measures of environmental health concern about nearby petrochemical production with a sample of Texas City residents to understand patterns of concern and change in concern after an industrial accident, as well as individual and contextual factors associated with those patterns. Survey interviews with residents of Texas City, Texas (N =315) both pre- and postexplosion using a brief Concern About Petrochemical Health Risk Scale (CAPHRS) and other questions were used to collect pertinent predictor information. CAPHRS baseline, postexplosion, and change scores were compared and modeled using ordinary least squares (OLS) regression and a mixed model. Higher preexplosion CAPHRS scores were predicted by younger adults, foreign-born Hispanics, non-Hispanic blacks, lower- and middle-income groups, and those who live with someone who has worked at the petrochemical plants. Higher CAPHRS change scores are predicted by the same variables (except income), as well as proximity to, or perception of, the explosion, and reports of neighborhood damage. Findings suggest these groups’ concern scores could indicate a greater vulnerability to psychological and physical harm generated by concern and stress arising from local petrochemical activities. A clearer understanding of concern about actual environmental health risks in exposed populations may enhance the evolving theory of stress and coping and eventually enable public health professionals to develop appropriate mitigation strategies

    Search for heavy neutral leptons decaying into muon-pion pairs in the MicroBooNE detector

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    This document was prepared by the MicroBooNE Collaboration using the resources of the Fermi National Accelerator Laboratory (Fermilab), a U.S. Department of Energy, Office of Science, HEP User Facility. Fermilab is managed by Fermi Research Alliance, LLC (FRA), acting under Contract No. DE-AC02-07CH11359. MicroBooNE is supported by the following: the U.S. Department of Energy, Office of Science, Offices of High Energy Physics and Nuclear Physics; the U.S. National Science Foundation; the Swiss National Science Foundation; the Science and Technology Facilities Council (STFC), part of the United Kingdom Research and Innovation; and The Royal Society (United Kingdom). Additional support for the laser calibration system and cosmic ray tagger was provided by the Albert Einstein Center for Fundamental Physics, Bern, Switzerland.We present upper limits on the production of heavy neutral leptons (HNLs) decaying to μπ pairs using data collected with the MicroBooNE liquid-argon time projection chamber (TPC) operating at Fermilab. This search is the first of its kind performed in a liquid-argon TPC. We use data collected in 2017 and 2018 corresponding to an exposure of 2.0×1020 protons on target from the Fermilab Booster Neutrino Beam, which produces mainly muon neutrinos with an average energy of ≈800  MeV. HNLs with higher mass are expected to have a longer time of flight to the liquid-argon TPC than Standard Model neutrinos. The data are therefore recorded with a dedicated trigger configured to detect HNL decays that occur after the neutrino spill reaches the detector. We set upper limits at the 90% confidence level on the element |Uμ4|2 of the extended PMNS mixing matrix in the range |Uμ4|2<(6.6–0.9)×10−7 for Dirac HNLs and |Uμ4|2<(4.7–0.7)×10−7 for Majorana HNLs, assuming HNL masses between 260 and 385 MeV and |Ue4|2=|Uτ4|2=0.Fermilab is managed by Fermi Research Alliance, LLC (FRA), acting under Contract No. DE-AC02-07CH1135

    Robert Owen, utopian socialism and social transformation

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    This paper critically scrutinizes accounts of Robert Owen’s life and works focusing on his purported “utopianism” and his supposedly deficient “socialism.” It suggests that such positions have relied on questionable assertions about the potential of particular modes of social transformation, and a failure to acknowledge the distinction Owen makes between the practical arrangements necessary to begin the process of transformation, and those arrangements that would ultimately prevail in “the new moral world.” It also argues that such accounts may contribute to the development of fatalistic narratives surrounding cooperative values and projects involving strategic compromise. In response, the paper reconsiders the significance of Owen through the lens of a “strategic presentism” that considers how Owen’s ideas can be thought of as significant contributions to theorizing social transformation

    IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System

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    PURPOSE: To improve persistence of adoptively transferred T-cell receptor (TCR)-engineered T cells and durable clinical responses, we designed a clinical trial to transplant genetically-modified hematopoietic stem cells (HSCs) together with adoptive cell transfer of T cells both engineered to express an NY-ESO-1 TCR. Here, we report the preclinical studies performed to enable an investigational new drug (IND) application. EXPERIMENTAL DESIGN: HSCs transduced with a lentiviral vector expressing NY-ESO-1 TCR and the PET reporter/suicide gene HSV1-sr39TK and T cells transduced with a retroviral vector expressing NY-ESO-1 TCR were coadministered to myelodepleted HLA-A2/Kb mice within a formal Good Laboratory Practice (GLP)-compliant study to demonstrate safety, persistence, and HSC differentiation into all blood lineages. Non-GLP experiments included assessment of transgene immunogenicity and in vitro viral insertion safety studies. Furthermore, Good Manufacturing Practice (GMP)-compliant cell production qualification runs were performed to establish the manufacturing protocols for clinical use. RESULTS: TCR genetically modified and ex vivo-cultured HSCs differentiated into all blood subsets in vivo after HSC transplantation, and coadministration of TCR-transduced T cells did not result in increased toxicity. The expression of NY-ESO-1 TCR and sr39TK transgenes did not have a detrimental effect on gene-modified HSC's differentiation to all blood cell lineages. There was no evidence of genotoxicity induced by the lentiviral vector. GMP batches of clinical-grade transgenic cells produced during qualification runs had adequate stability and functionality. CONCLUSIONS: Coadministration of HSCs and T cells expressing an NY-ESO-1 TCR is safe in preclinical models. The results presented in this article led to the FDA approval of IND 17471