41 research outputs found

    RESTRIÇÃO ALIMENTAR DE MACROBRACHIUM ROSENBERGII CULTIVADO EM SISTEMA DE BIOFLOCOS

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    O objetivo deste trabalho foi avaliar o desempenho zoot√©cnico do camar√£o-daMal√°sia, Macrobrachium rosenbergii criados em sistema de biofloco e submetidos √†restri√ß√£o alimentar. Foram utilizadas 400 p√≥s-larvas do camar√£o distribu√≠das em doistratamentos; camar√Ķes alimentados sete dias na semana (controle) e camar√Ķesalimentados com restri√ß√£o nos finais de semana (s√°bado e domingo n√£o foi ofertadadieta). Tanto os par√Ęmetros zoot√©cnicos como os par√Ęmetros de qualidade de √°guan√£o apresentaram diferen√ßas significativas entre os tratamentos controle e restri√ß√£oalimentar. Portanto, o manejo de restri√ß√£o pode ser utilizado como alternativa pararedu√ß√£o de custos com alimenta√ß√£o artificial e m√£o-de-obra

    AVALIA√á√ÉO DE DIETA PR√ĀTICA SEM FARINHA DE PEIXE NO BIOFLOCO PARA TIL√ĀPIA

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    Devido a intensifica√ß√£o da piscicultura, aumenta a demanda por ra√ß√Ķes comercias que possamsuprir a necessidade. Entretanto, a obten√ß√£o da principal fonte de prote√≠na, a farinha de peixe,n√£o acompanhou esse crescimento, apresentando decl√≠nios da produ√ß√£o mundial econsequentemente o aumento do pre√ßo desse produto. Assim, o objetivo desse trabalho foiavaliar o desempenho zoot√©cnico da til√°pia-do-nilo (Oreochromis niloticus), alimentadas comdieta sem farinha de peixe e a influ√™ncia nas vari√°veis de qualidade de √°gua, no cultivo emsistema de bioflocos (BFT). O experimento foi realizado no Laborat√≥rio de Aquicultura doIFC- Araquari. Foram utilizados 300 alevinos de til√°pia-do-nilo, distribu√≠dos em seis caixasde polietileno (250 L √ļteis cada), sendo divididas em dois tratamentos, peixes alimentadoscom dieta controle (formulada com farinha de peixe) e peixes alimentados com dieta semfarinha de peixe. A fertiliza√ß√£o da √°gua dos tanques antes e durante o experimento foi feitacom uma fonte de carbono (a√ß√ļcar) e ra√ß√£o mo√≠da para manuten√ß√£o da rela√ß√£o carbono:nitrog√™nio em 10:1. Durante o experimento foram monitorados: oxig√™nio dissolvido,temperatura e volume de flocos, pH, am√īnia (total e t√≥xica), nitrito e nitrato. Ap√≥s seissemanas, foram avaliados os par√Ęmetros zoot√©cnicos (Tabela 1), no qual os peixesalimentados com a dieta experimental apresentaram um menor custo por kg de peixeproduzido; enquanto os demais par√Ęmetros zoot√©cnicos e de qualidade de √°gua n√£o variaramentre os tratamentos. A utiliza√ß√£o da dieta sem farinha de peixe na cria√ß√£o de til√°pia-do-niloem BFT reduz em 6% o custo com a alimenta√ß√£o, sem comprometer o desempenhozoot√©cnico desses animais. &nbsp

    ADI√á√ÉO DE TAURINA EM DIETAS DE TIL√ĀPIA-DO-NILO (Oreochromis niloticus)

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    O objetivo deste trabalho foi avaliar propriedades física e microbiológicas dediferentes dietas. As três dietas foram produzidas na Nutricol: dieta comercial; umcom substituição da farinha de peixe (FP) por farelo de soja; e com substituiçãoinclusão da taurina mais substituição da FP. As dietas foram avaliadas quanto a suaexpansão dos pellets, desintegração, flutuabilidade e contagem microbiológica. Ataurina reduziu a flutuabilidade e aumentou o custo das dietas, assim como adietasem farinha de peixe apresentou menor contagem de contagem bacteriana. Concluiseque o uso de taurina na dieta e retirada da farinha de peixe interfere as dietas

    Practical diet with total replacement of fishmeal by soybean meal for Nile tilapia: growth performance and health effects

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    This study aimed to evaluate the growth performance and animal health in juveniles of Nile tilapia (Oreochromis niloticus) fed a practical diet with total replacement of fishmeal (FM) by soybean meal, as well the effect on survival, following pathogenic challenge with Aeromonas hydrophila. Two hundred juveniles of Nile tilapia were stored in 8 tanks (800 L). The experiment consisted of two treatments: a commercial diet formulated with FM (control) and a practical diet with total replacement of FM by soybean meal (SM). The variables of water quality, zootechnical and hematological parameters were measured. In addition, at the end of the experiment, the fish were submitted to a challenge with A. hydrophila. Higher cost per kg of fish was obtained in the control treatment (with FM). N retention was higher in fish fed a diet without FM, while hematological, immunological parameters and survival after the experimental challenge did not differ between treatments. It is possible to reduce dietary costs by replacing FM with SM without affecting growth performance or animal health, in addition to benefiting the environment by reducing the excretion of N in water. Keywords: plant protein; Aeromonas hydrophila; nitrogen retention; immunology

    Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

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    Funder: Funder: Fundaci√≥n bancaria ‚ÄėLa Caixa‚Äô Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n‚ÄČ=‚ÄČ409,435 and validation size n‚ÄČ=‚ÄČ58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE …õ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

    New insights into the genetic etiology of Alzheimer's disease and related dementias

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    Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE őĶ4 allele

    Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.

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    Funder: Funder: Fundaci√≥n bancaria ‚ÄėLa Caixa‚Äô Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n‚ÄČ=‚ÄČ409,435 and validation size n‚ÄČ=‚ÄČ58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE …õ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

    Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

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    Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson‚Äôs disease (PD) and Alzheimer‚Äôs disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aő≤42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
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