33 research outputs found

    Study of Negative-Ion TPC Using {\mu}-PIC for Directional Dark Matter Search

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    Negative-ion time projection chambers(TPCs) have been studied for low-rate and high-resolution applications such as dark matter search experiments. Recently, a full volume fiducialization in a self-triggering TPC was realized. This innovative technology demonstrated a significant reduction in the background with MWPC-TPCs. We studied negative-ion TPC using the {\mu}-PIC+GEM system and obtained sufficient gas gain with CS2_{2}gas and SF6_{6} gas at low pressures. We expect an improvement in detector sensitivity and angular resolution with better electronics

    A comparison of the nutritional content of processed foods available on the French market, according to the type of brand, and potential impact on nutrient intakes—An Oqali study

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    The French Observatory of Food Quality (Oqali) aims to collect all nutrition data provided on processed food labels, at the level of brand products, in order to monitor reformulation and nutrition labeling changes over time. This work aimed to make a cross‐sectional comparison of the nutrition content of processed foods on the French market, according to their type of brand (national brands, retailer brands, entry‐level retailer brands, hard discount, and specialized retailer brands), and to study the potential impact of the differences observed on simulated nutrient intakes. A total of 16,453 branded processed foodstuffs were considered, collected between 2008 and 2011 and divided into 24 food sectors. Labeled nutrition values were compared between types of brands by family of products. Nutrition values were matched with consumption data from the French Individual and National Study on Food Consumption (INCA 2) (Afssa, 2006–2007) to determine whether the nutrition differences underlined were magnified or diminished when crossing them with consumption data. Only isolated differences in nutrient contents between types of brands could be highlighted. In the case of a theoretical and exclusive consumption of processed foodstuffs from one specific type of brand, protein intakes from first‐price products (entry‐level retailer brands and hard discount) appeared to be significantly lower than the ones from national or retailer brand products. The absence of systematic differences in the nutrition contents of processed foods from various types of brands is an encouraging result when considering social inequalities and nutrition. As protein intakes in France are currently above recommended levels (Afssa, 2007), consumption of first‐price foodstuffs does not imply any risk of deficiency for French consumers

    Étiquetage des allergĂšnes alimentaires dans les produits transformĂ©s français

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    JournĂ©es francophones de nutrition, Marseille 2015International audienceIntroduction et but de l’étude : L’Oqali a pour mission de suivre l’évolution de la qualitĂ© nutritionnelle de l’offre alimentaire des produits transformĂ©s (informations et composition nutritionnelles disponibles sur les emballages). Cette Ă©tude a pour objectif de rĂ©aliser un Ă©tat des lieux des taux de prĂ©sence dans les listes d’ingrĂ©dients et d’étiquetage de prĂ©caution des 14 catĂ©gories d’allergĂšnes alimentaires Ă  dĂ©claration obligatoire : gluten, crustacĂ©s, Ɠuf, poissons, arachide, soja, lait, fruits Ă  coque, cĂ©leri, moutarde, sĂ©same, sulfites, lupin et mollusques. [...

    Study of Negative-Ion TPC Using Ό-PIC for Directional Dark Matter Search

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    Negative-ion time projection chambers(TPCs) have been studied for low-rate and high-resolution applications such as dark matter search experiments. Recently, a full volume fiducialization in a self-triggering TPC was realized. This innovative technology demonstrated a significant reduction in the background with MWPC-TPCs. We studied negative-ion TPC using the Ό-PIC+GEM system and obtained sufficient gas gain with CS2 gas and SF6 gas at low pressures. We expect an improvement in detector sensitivity and angular resolution with better electronics

    Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia

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    A map of 191 single-nucleotide polymorphism (SNPs) was built across a 5-Mb segment from chromosome 13q34 that has been genetically linked to schizophrenia. DNA from 213 schizophrenic patients and 241 normal individuals from Canada were genotyped with this marker set. Two 1,400- and 65-kb regions contained markers associated with the disease. Two markers from the 65-kb region were also found to be associated to schizophrenia in a Russian sample. Two overlapping genes G72 and G30 transcribed in brain were experimentally annotated in this 65-kb region. Transfection experiments point to the existence of a 153-aa protein coded by the G72 gene. This protein is rapidly evolving in primates, is localized to endoplasmic reticulum/Golgi in transfected cells, is able to form multimers and specifically binds to carbohydrates. Yeast two-hybrid experiments with the G72 protein identified the enzyme d-amino acid oxidase (DAAO) as an interacting partner. DAAO is expressed in human brain where it oxidizes d-serine, a potent activator of N-methyl-D-aspartate type glutamate receptor. The interaction between G72 and DAAO was confirmed in vitro and resulted in activation of DAAO. Four SNP markers from DAAO were found to be associated with schizophrenia in the Canadian samples. Logistic regression revealed genetic interaction between associated SNPs in vicinity of two genes. The association of both DAAO and a new gene G72 from 13q34 with schizophrenia together with activation of DAAO activity by a G72 protein product points to the involvement of this N-methyl-d-aspartate receptor regulation pathway in schizophrenia
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