25 research outputs found

    Animating potential for intensities and becoming in writing: challenging discursively constructed structures and writing conventions in academia through the use of storying and other post qualitative inquiries

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    Written for everyone ever denied the opportunity of fulfilling their academic potential, this is ‘Chloe’s story’. Using composite selves, a phrase chosen to indicate multiplicities and movement, to story both the initial event leading to ‘Chloe’s’ immediate withdrawal from a Further Education college and an imaginary second chance to support her whilst at university, this Deleuzo-Guattarian (2015a) ‘assemblage’ of post qualitative inquiries offers challenge to discursively constructed structures and writing conventions in academia. Adopting a posthuman approach to theorising to shift attention towards affects and intensities always relationally in action in multiple ‘assemblages’, these inquiries aim to decentre individual ‘lecturer’ and ‘student’ identities. Illuminating movements and moments quivering with potential for change, then, hoping thereby to generate second chances for all, different approaches to writing are exemplified which trouble those academic constraints by fostering inquiry and speculation: moving away from ‘what is’ towards ‘what if’. With the formatting of this thesis itself also always troubling the rigid Deleuzo-Guattarian (2015a) ‘segmentary lines’ structuring orthodox academic practice, imbricated in these inquiries are attempts to exemplify Manning’s (2015; 2016) ‘artfulness’ through shifts in thinking within and around an emerging PhD thesis. As writing resists organising, the verb thesisising comes into play to describe the processes involved in creating this always-moving thesis. Using ‘landing sites’ (Arakawa and Gins, 2009) as a landscaping device, freely creating emerging ‘lines of flight’ (Deleuze and Guattari, 2015a) so often denied to students forced to adhere to strict academic conventions, this ‘movement-moving’ (Manning, 2014) opens up opportunities for change as in Manning’s (2016) ‘research-creation’. Arguing for a moving away from writing-representing towards writing-inquiring, towards a writing ‘that does’ (Wyatt and Gale, 2018: 127), and toward writing as immanent doing, it is hoped to animate potential for intensities and becoming in writing, offering opportunities and glimmerings of the not-yet-known

    The James Webb Space Telescope Mission

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    Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least 4m4m. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the 6.5m6.5m James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

    Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

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    Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

    The action of non-depolarising muscle relaxants at nicotinic acetylcholine receptors

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    The mechanism of action of short-acting, non-depolarising neuromuscular blocking agents at nicotinic acetylcholine receptors (nAChRs) was investigated. The effect of three such antagonists, d-tubocurarine (d-TC), pancuronium and its structural analogue vecuronium on nAChRs were investigated at nAChRs expressed in Xenopus laevis oocytes following injection of in vitro transcribed mRNA, and also in the in vivo preparation of the mouse phrenic nerve diaphragm. The foetal and adult forms of the mouse muscle nAChR were expressed in oocytes. Two-electrode voltage-clamp techniques were used to study the receptors. Acethylcholine concentration-response curves were obtained (EC50 11.6±4.3&mu;M, n=21 foetal; 17.4±1.0&mu;M, n=31 adult). The doses of acetylcholine used to construct the concentration-response curve were repeated in the presence of 10nM pancuronium, 10nM d-TC and 10nM vecuronium. The block produced by 10nM vecuronium was greater than 70% for all the concentrations of acethylcholine used. Dose ratios were calculated for d-TC and pancuronium, which were used to estimate the apparent dissociation constants (KD'), 6.54nM and 0.71nM respectively for foetal, and 1.88nM (d-TC) and 0.61nM (pancuronium). The antagonism for all three compounds was reversible. In both receptor subtypes, the antagonists blocked the response to 1&mu;M ACh in a voltage-independent manner (-40mV to - 100mV). The IC50 values for the 3 antagonists against 1&mu;M ACh at the foetal muscle nAChR (clamped at -80mV), were: d-TC 7400±800pM (n=4), pancuronium 5.0±1.9pM (n=4), vecuronium 5.9±2.1pM (n=4). Two neuronal type nAChRs, α4ÎČ2 and the homomeric α7 were also expressed in oocytes. Pancuronium was shown to be more potent than d-TC at the α4ÎČ2 nAChR, whilst both compounds were equipotent at the α7 nAChR. A chimaeric receptor comprising of muscle α, Δ and &delta; subunits with the neuronal ÎČ2 was expressed in oocytes.</p