6 research outputs found

    L'ICSI in pazienti poor responders: la metodica migliore?

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    Objective: to evaluate and, if it possible, to improve the result of FIVET cycles in "poor responders" patients by intracitoplasmatic spermatozoon injection (ICSI). Methodology and materials: from january 2006 to june 2008 we tested 80 poor responders women with normal semen partner (sec.WHO 1999: n¬į spermatozoon >20 million /ml; mobility > 50%; normal forms > 30%) or with light oligoospermia. The 80 women were random selected into 2 groups: the group 1 with 40 poor responder women with 40 ICSI cycles. The group 2 with 40 poor responder women with 40 FIVET cycles Results: significant differences between the 2 groups about the stimulation and fecundation parameters weren‚Äôt highlighted while the implantation and the normal pregnancy rates where significantly in favour of ICSI. Conclusions: ICSI in poor responder women, with normal semen partners, gives the best results about implantation and pregnancy rates in comparison to FIVET

    Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

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    Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low‚Äďmiddle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‚Äėsingle-use‚Äô consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low‚Äďmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high‚Äď and low‚Äďmiddle‚Äďincome countries

    Cancer Stem Cells and Nanomedicine

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    physiological process of cell renewal necessary for the survival of the organism. For tissues such as blood and skin is a daily replacement with younger cells that replace the old ones. In other tissues, such as brain and heart, this replacement is much more reduced. At the base of these regenerative processes there are populations of reserve cells located in different tissues, the more abundant the greater the regenerative capacity and the necessity of that tissue. Immature cells capable of self-maintained, that is, endlessly multiplied by generating identical cells to themselves. While replicating, stem cells also retain the ability to specialize in different mature cell types of the tissues and organs in which they are located. It is through for the double activity that stem cells of our body replicate and specialize every day to replace worn cells and allow the body to survive. It was the Russian scientist Alexander Maximov in 1906 to introduce for the first time the term ‚Äėstammzelle‚Äô (from ‚ÄúStamm‚ÄĚ, jamb, and ‚Äúzelle‚ÄĚ, cell) to refer to individual cells of a cell lineage progenitors. And it is of the fifties the first experimental evidence of the existence of stem in the body. However, the searchlights have been turned on these cells only since 1998, when a special stem cell has been isolated from human blastocyst (an early stage of embryo development): the embryonic stem cell.</p

    How important is the Morphology of the Semen Analysis?

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    Introduction: Male infertility is evaluated throughout the quantitative and qualitative analysis of male’s semen and the sperm contained therein. One of the most essential part of this process is the evaluation of the cytomorphology of man’s semen. We could reach a correct measurement of the morphology using stained smears that allow the differentiation of other cells like white blood cells and immature sperm cells that could indicate an infection or inflammation.Case report: This article reports two case studies of patients with examination results as below:Conclusion: Disorders in the mechanism of oocyte activation could be one of the origins of unsuccessful Intra- cytoplasmic sperm injection (ICSI). Normally this process starts with the spermoocyte merging, inducted from a calcium influx into the oocyte. The level of calcium alteration trigger factor is generated from an acrosome’s component called phospholipase C zeta (PLCz). If this is absent (as in men with globozoospermia), then assisted oocyte activation needs to achieved by alternative means, such as by using a calcium ionophore.</p

    Risks and usefulness of sonohysterography in patients with endometrial carcinoma

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    Objective: The purposes of this study were to assess the risk of malignant cell dissemination into the peritoneal cavity through the fallopian tubes in patients with endometrial carcinoma undergoing sonohysterography and to evaluate the accuracy of sonohysterography in the estimation of myometrial invasion by the tumor and its role in the preoperative staging. Study design: This was a prospective study that was conducted at the Sassari University hospital. Thirty-two patients with endometrial carcinoma underwent sonohysterography during laparotomy for hysterectomy. The fluid that spilled from the fallopian tubes and was collected into graduated plastic tubes was analyzed by a pathologist. The presence of malignant endometrial cells in the fluid that was spilled from the fallopian tubes was assessed. The depth of myometrial invasion by tumor was assessed by gross and sonohysterographic examinations and compared with histopathologic findings. Results: Malignant cells were reported in the fluid that spilled from the fallopian tubes in 2 patients (6.25%). The occurrence of suspected cells in the fallopian fluid was reported in 6 women (18.75%); thus, the presence of malignant or suspicious cells in the fluid that spilled from the fallopian tubes was reported in 8 of 32 cases (25%). Sonohysterography correctly evaluated the depth of myometrial invasion in 27 of 32 cases (84.37%). Conclusion: Sonohysterography was useful to assess the depth of myometrial invasion and may have a role in preoperative staging, but sonohysterography should not be performed in women with suspicious diagnosis of endometrial carcinoma

    Correction to: Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial

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