1,219 research outputs found

    Misurazione dell'angolo ő≥ ottenuta attraverso una combinazione bayesiana di risultati dell'esperimento LHCb

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    L'esperimento LHCb si occupa di realizzare misure di precisione nell'ambito della fisica del flavour, al fine di verificare la validit√† delle previsioni del Modello Standard. Nel Modello Standard, le trasformazioni degli stati di flavour dei quark sono descritti mediante la matrice CKM (Cabibbo-Kobayashi-Maskawa). Uno degli obiettivi principali di LHCb √® la misura del parametro ő≥ associato a questa matrice. La misura di ő≥ √® ottenuta combinando i risultati dell'analisi di vari decadimenti dei mesoni B. La combinazione √® complicata dal fatto che molti degli osservabili di ciascuba misura sono legati a ő≥ solo tramite equazioni non lineari. Inoltre sono presenti molti parametri addizionali (parametri "nuisance") che devono essere determinati insieme a ő≥. In questa tesi si fornisce una stima di ő≥ ottenuta tramite una combinazione bayesiana di dodici misurazioni realizzate da LHCb. Questa combinazione verr√† chiamata "DK only", in quanto contiene solo osservabili misurate nei decadimenti del tipo B->DK

    Immunoscintigraphy for therapy decision making and follow-up of biological therapies

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    With the availability of new biological therapies there is the need of more accurate diagnostic tools to noninvasively assess the presence of their targets. In this scenario nuclear medicine offers many radiopharmaceuticals for SPECT or PET imaging of many pathological conditions. The availability of monoclonal antibodies provides tools to target specific antigens involved in angiogenesis, cell cycle or modulation of the immune systems. The radiolabelling of such therapeutic mAbs is a promising method to evaluate the antigenic status of each cancer lesion or inflamed sites before starting the therapy. It may also allow to perform follow-up of such biological therapies. In the present review we provide an overview of the most studied radiolabelled antibodies for therapy decision making and follow-up of patients affected by cancer and other pathological conditions

    Tickling the CMB damping tail: scrutinizing the tension between the ACT and SPT experiments

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    The Atacama Cosmology Telescope (ACT) and the South Pole Telescope (SPT) have recently provided new, very precise measurements of the cosmic microwave background (CMB) anisotropy damping tail. The values of the cosmological parameters inferred from these measurements, while broadly consistent with the expectations of the standard cosmological model, are providing interesting possible indications for new physics that are definitely worth of investigation. The ACT results, while compatible with the standard expectation of three neutrino families, indicate a level of CMB lensing, parametrized by the lensing amplitude parameter A_L, that is about 70% higher than expected. If not a systematic, this anomalous lensing amplitude could be produced by modifications of general relativity or coupled dark energy. Vice-versa, the SPT experiment, while compatible with a standard level of CMB lensing, prefers an excess of dark radiation, parametrized by the effective number of relativistic degrees of freedom N_eff. Here we perform a new analysis of these experiments allowing simultaneous variations in both these, non-standard, parameters. We also combine these experiments, for the first time in the literature, with the recent WMAP9 data, one at a time. Including the Hubble Space Telescope (HST) prior on the Hubble constant and information from baryon acoustic oscillations (BAO) surveys provides the following constraints from ACT: N_eff=3.23\pm0.47, A_L=1.65\pm0.33 at 68% c.l., while for SPT we have N_eff=3.76\pm0.34, A_L=0.81\pm0.12 at 68% c.l.. In particular, the A_L estimates from the two experiments, even when a variation in N_eff is allowed, are in tension at more than 95% c.l..Comment: 7 pages, 7 figures, v.2. some typos and sentences correcte

    Assessment for sonographic grading scales of the body fat changes related to the lipoatrophic findings of HIV patients in treatment with HAART

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    Methods We enrolled non-obese HIV patients (73 males and 42 females; body mass index <27 kg/m2). Clinical assessments of BFCs were defined by correspondence between the self-reports of patients and medical examinations. Fat redistribution was scored separately for face, arm and lower limbs on a scale ranging from 0 (absence) to 1 (mid) and 2‚Äď3 (severe BFCs). US scans of subcutaneous fat thickness (SFT) were performed at 3 reference points: transversal scan at the deepest point of Bichat pad (facial SFT), long dorsal scan of arm (brachial SFT), and long scan of anterior face of thigh (crural SFT)

    Kinematics Adaptation and Inter-Limb Symmetry during Gait in Obese Adults

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    The main purpose of this study is to characterize lower limb joint kinematics during gait in obese individuals by analyzing inter-limb symmetry and angular trends of lower limb joints during walking. To this purpose, 26 obese individuals (mean age 28.5 years) and 26 normal-weight age- and sex-matched were tested using 3D gait analysis. Raw kinematic data were processed to derive joint-specific angle trends and angle-angle diagrams (synchronized cyclograms) which were characterized in terms of area, orientation and trend symmetry parameters. The results show that obese individuals exhibit a kinematic pattern which significantly differs from those of normal weight especially in the stance phase. In terms of inter-limb symmetry, higher values were found in obese individuals for all the considered parameters, even though the statistical significance was detected only in the case of trend symmetry index at ankle joint. The described alterations of gait kinematics in the obese individuals and especially the results on gait asymmetry are important, because the cyclic uneven movement repeated for hours daily can involve asymmetrical spine loading and cause lumbar pain and could be dangerous for overweight individuals

    Is HAART based on newest active antiretroviral drugs influenced by GSS

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    Methods Major enrollment criterion was the administration of maraviroc, enfuvirtide, raltegravir, etravirine, darunavir/r or tipranavir/r, alone or in combination, in the latest antiretroviral regimen, decided upon the last genotypic RNA resistance test. This allowed us to assess the genotypic sensitivity score (GSS) at the same time. We also recorded previous presence of specific mutations in all available genotypic resistance tests, their persistence in time and their correlation to the last GSS

    Functional electrical stimulation for foot drop in post-stroke people: quantitative effects on step-to-step symmetry of gait using a wearable inertial sensor

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    The main purpose of the present study was to assess the effects of foot drop stimulators (FDS) in individuals with stroke by means of spatio-temporal and step-to-step symmetry, harmonic ratio (HR), parameters obtained from trunk accelerations acquired using a wearable inertial sensor. Thirty-two patients (age: 56.84 ¬Ī 9.10 years; 68.8% male) underwent an instrumental gait analysis, performed using a wearable inertial sensor before and a day after the 10-session treatment (PRE and POST sessions). The treatment consisted of 10 sessions of 20 min of walking on a treadmill while using the FDS device. The spatio-temporal parameters and the HR in the anteroposterior (AP), vertical (V), and mediolateral (ML) directions were computed from trunk acceleration data. The results showed that time had a significant effect on the spatio-temporal parameters; in particular, a significant increase in gait speed was detected. Regarding the HRs, the HR in the ML direction was found to have significantly increased (+20%), while those in the AP and V directions decreased (approximately 13%). Even if further studies are necessary, from these results, the HR seems to provide additional information on gait patterns with respect to the traditional spatio-temporal parameters, advancing the assessment of the effects of FDS devices in stroke patients

    Software Challenges For HL-LHC Data Analysis

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    The high energy physics community is discussing where investment is needed to prepare software for the HL-LHC and its unprecedented challenges. The ROOT project is one of the central software players in high energy physics since decades. From its experience and expectations, the ROOT team has distilled a comprehensive set of areas that should see research and development in the context of data analysis software, for making best use of HL-LHC's physics potential. This work shows what these areas could be, why the ROOT team believes investing in them is needed, which gains are expected, and where related work is ongoing. It can serve as an indication for future research proposals and cooperations

    Dupilumab in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP): A multicentric observational Phase IV real-life study (DUPIREAL)

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    Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with significant morbidity and reduced health-related quality of life. Findings from clinical trials have demonstrated the effectiveness of dupilumab in CRSwNP, although real-world evidence is still limited. Methods This Phase IV real-life, observational, multicenter study assessed the effectiveness and safety of dupilumab in patients with severe uncontrolled CRSwNP (n‚ÄČ=‚ÄČ648) over the first year of treatment. We collected data at baseline and after 1, 3, 6, 9, and 12‚ÄČmonths of follow-up. We focused on nasal polyps score (NPS), symptoms, and olfactory function. We stratified outcomes by comorbidities, previous surgery, and adherence to intranasal corticosteroids, and examined the success rates based on current guidelines, as well as potential predictors of response at each timepoint. Results We observed a significant decrease in NPS from a median value of 6 (IQR 5‚Äď6) at baseline to 1.0 (IQR 0.0‚Äď2.0) at 12‚ÄČmonths (p‚ÄČ&lt;‚ÄČ.001), and a significant decrease in Sino-Nasal Outcomes Test-22 (SNOT-22) from a median score of 58 (IQR 49‚Äď70) at baseline to 11 (IQR 6‚Äď21; p‚ÄČ&lt;‚ÄČ.001) at 12‚ÄČmonths. Sniffin' Sticks scores showed a significant increase over 12‚ÄČmonths (p‚ÄČ&lt;‚ÄČ.001) compared to baseline. The results were unaffected by concomitant diseases, number of previous surgeries, and adherence to topical steroids, except for minor differences in rapidity of action. An excellent-moderate response was observed in 96.9% of patients at 12‚ÄČmonths based on EPOS 2020 criteria. Conclusions Our findings from this large-scale real-life study support the effectiveness of dupilumab as an add-on therapy in patients with severe uncontrolled CRSwNP in reducing polyp size and improving the quality of life, severity of symptoms, nasal congestion, and smell
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