12 research outputs found

### Example of hierarchical Bayesian model to estimate APOE4 genotype of a subject based on the age and age of AD onset of the subject and his parents and grandparents.

<p>Example of hierarchical Bayesian model to estimate APOE4 genotype of a subject based on the age and age of AD onset of the subject and his parents and grandparents.</p

### Theoretical Bayesian probability of APOE4 genotype based on age of AD onset.

<p>These functions form the basis for the P(AGE|Genotype) variable used in determining posterior probability P(Genotype|AGE). At early ages, the sum of the genetics add up to above 100% since the probability of autosomal dominant genes does not figure into the probabilities of have any of the APOE4 genotypes, which do add up to 100%. This graph is obtained using the conditional probability equation of .</p

### A hierarchical Bayesian model to predict APOE4 genotype and the age of Alzheimerās disease onset - Table 1

<p>A hierarchical Bayesian model to predict APOE4 genotype and the age of Alzheimerās disease onset</p> - Table

### Gompertz AD onset risk function for the general population (ābaselineā), the subjectās estimated APOE status (āgenetic riskā), and risk factoring in known risk factors (āfactored riskā).

<p>Notice the risk increases steadily until approximately age 80, at which point the risk grows at a slower rate. This is because there is a probability that this individual will never have AD. The baseline risk is calculated by applying the model to the āaverageā person, that has APOE4 genotype probability status equal to that of the population.</p

### A hierarchical Bayesian model to predict APOE4 genotype and the age of Alzheimerās disease onset - Table 3

<p>A hierarchical Bayesian model to predict APOE4 genotype and the age of Alzheimerās disease onset</p> - Table

### Force Spectroscopy Setup.

<p>A schematic of experimental setup of force spectroscopy experiment showing AĪ² bound to substrate and tip via the PEG linker.</p

### Statistical Data of Force Spectroscopy Experiments.

<p>Statistical Data of Force Spectroscopy Experiments.</p

### Schematic diagram of AĪ² dimers with and without copper.

<p>Without copper, the most favorable conformation of the AĪ² dimer involves an anti-parallel conformation (A). With the addition of copper, AĪ² adopts a parallel dimer conformation (B) stabilized by the occupied copper binding sites (C).</p

### Representative force curves.

<p>Force curves showing rupture forces of an AĪ² dimer without (A) and with (B) copper added at a retraction rate of 400 nm/s. Curves are shown as force vs. piezo z-displacement.</p

### AFM images of amyloid-metal aggregates.

<p>AFM images of AĪ² incubated without copper for periods of 1 hr (A) 6 hr (B) and 24 hr (C), and with copper at a 10ā¶1 molar ratio for 1 hr (D), 6 hr (E), and 24 hr (F). The lateral scale bar is 1 Āµm.</p