77 research outputs found

    Recent progress in biomedical sensors based on conducting polymer hydrogels

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    Biosensors are increasingly taking a more active role in health science. The current needs for the constant monitoring of biomedical signals, as well as the growing spending on public health, make it necessary to search for materials with a combination of properties such as biocompatibility, electroactivity, resorption, and high selectivity to certain bioanalytes. Conducting polymer hydrogels seem to be a very promising materials, since they present many of the necessary properties to be used as biosensors. Furthermore, their properties can be shaped and enhanced by designing conductive polymer hydrogel-based composites with more specific functionalities depending on the end application. This work will review the recent state of the art of different biological hydrogels for biosensor applications, discuss the properties of the different components alone and in combination, and reveal their high potential as candidate materials in the fabrication of all-organic diagnostic, wearable, and implantable sensor devices.Peer ReviewedPostprint (published version

    Scaffolds for sustained release of ambroxol hydrochloride, a pharmacological Chaperone that Increases the Activity of Misfolded Ăź-Glucocerebrosidase

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    Ambroxol is a pharmacological chaperone (PC) for Gaucher disease that increases lysosomal activity of misfolded Ăź-glucocerebrosidase (GCase) while displaying a safe toxicological profile. In this work, different poly(e-caprolactone) (PCL)-based systems are developed to regulate the sustained release of small polar drugs in physiological environments. For this purpose, ambroxol is selected as test case since the encapsulation and release of PCs using polymeric scaffolds have not been explored yet. More specifically, ambroxol is successfully loaded in electrospun PCL microfibers, which are subsequently coated with additional PCL layers using dip-coating or spin-coating. The time needed to achieve 80% release of loaded ambroxol increases from Ëś15 min for uncoated fibrous scaffolds to 3 days and 1 week for dip-coated and spin-coated systems, respectively. Furthermore, it is proven that the released drug maintains its bioactivity, protecting GCase against induced thermal denaturationPeer ReviewedPostprint (author's final draft

    Ultracapacitors made with Hybrid conducting polymer–clay exfoliated nanocomposites

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    Ultracapacitors form exfoliated nanocomposites of poly(3,4-ethylenedioxythiophene) (PEDOT), and montmorillonite (MMT), have been fabricated, and have been characterized by electrochemical and macroscopic methods, found to present very good electrical properties (e.g. the specific capacitance), evidencing the favorable effect of the clay, and the thinness of the film.Peer Reviewe
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