3 research outputs found

    The Process of Digital Transformation in Education During the COVID-19 Pandemic

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    Purpose: This document seeks to delve into the digital transformation of education during the COVID-19 pandemic, aiming to provide a comprehensive understanding of this evolving phenomenon's purpose and significance.   Design/Methodology/Approach: The research approach undertaken is characterized by a non-experimental, documentary, exploratory, and descriptive study methodology, which involves an extensive examination of existing literature and data to gain insights into the digital transformation in education during the pandemic.   Findings: The study's key findings revolve around the consensus in existing literature regarding the swift acceleration of the transformation of education from traditional face-to-face classes to virtual learning environments. It also highlights the implications of this transformation, particularly in reshaping teaching models and advocating for a hybrid approach encompassing both face-to-face and virtual learning.   Research, Practical & Social implications: The implications of this research extend to informing educational institutions about the need for digital adaptation, guiding policymakers in supporting adaptable learning models, and empowering educators with a deeper understanding of the changing educational landscape. Moreover, it considers the broader societal impact, including equity and access issues in education.   Originality/Value: This research is unique in its contribution to understanding the profound impact of the COVID-19 pandemic on education. It emphasizes the significance of adaptability and hybrid learning models while providing a foundation for future educational research and policy development

    Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

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    The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality