6,734 research outputs found

    generalized Radon transforms on fractal measures

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    In the setting of a general Borel measure μ\mu on RdR^d with the natural ball size condition μ[B(x,r)]Crs,\mu[B(x,r)]\leq Cr^s, we establish the Lp(μ)L^p(\mu)-Lq(μ)L^q(\mu)-estimate for the generalized Radon transform (Af)(x):=Φ(x,y)=0(fμ)(y)ψ(x,y)dσx(y),(Af)(x):=\int_{\Phi(x,y)=0}(f\mu)(y)\psi(x,y)d\sigma_x(y), where Φ\Phi is a smooth function away from the diagonal. Among other reasonable assumptions, an L2L^2-Sobolev bound on AA on RdR^d is imposed. This bound is satisfied in many natural situations. The main result is, in general, sharp up to endpoints

    Kedudukan Hukum Adat Duan Lolat Terhadap Penyelesaian Delik Dalam Criminal Justice System

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    The State of Indonesia is a State of Law (rechtstaat/staats law), which completely separates positive law (positivism law) from customary law (adatrecht) as unwritten law (custom), so that when a criminal act/criminal action occurs (delict) the state with all its powers according to the law (formal criminal law and material criminal law) through the related judiciary (sub system) acts to defend state law in order to protect the interests of the injured legal subject (victim). The results show that the system and values ​​and laws of the Duan-Lolat customary law have a position in national law as a sub-system of the Indonesian customary law system so that Duan-Lolat customary law gets its position in the criminal justice system without invalidating the national law in this case. material criminal law and the ideal form of criminal justice system in accommodating Duan-Lolat customary law against the settlement of offenses at the pre-adjudication and adjudication stages carried out by the authorized sub-system as a component of criminal justice

    A One Health overview, facilitating advances in comparative medicine and translational research.

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    Table of contentsA1 One health advances and successes in comparative medicine and translational researchCheryl StroudA2 Dendritic cell-targeted gorilla adenoviral vector for cancer vaccination for canine melanomaIgor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. CurielA3 Viroimmunotherapy for malignant melanoma in the companion dog modelJeffrey N. Bryan, David Curiel, Igor Dmitriev, Elena Kashentseva, Hans Rindt, Carol Reinero, Carolyn J. HenryA4 Of mice and men (and dogs!): development of a commercially licensed xenogeneic DNA vaccine for companion animals with malignant melanomaPhilip J. BergmanA5 Successful immunotherapy with a recombinant HER2-expressing Listeria monocytogenes in dogs with spontaneous osteosarcoma paves the way for advances in pediatric osteosarcomaNicola J. Mason, Josephine S. Gnanandarajah, Julie B. Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha, Margie Huebner, Yvonne PatersonA6 Human clinical development of ADXS-HER2Daniel O'ConnorA7 Leveraging use of data for both human and veterinary benefitLaura S. TremlA8 Biologic replacement of the knee: innovations and early clinical resultsJames P. StannardA9 Mizzou BioJoint Center: a translational success storyJames L. CookA10 University and industry translational partnership: from the lab to commercializationMarc JacobsA11 Beyond docking: an evolutionarily guided OneHealth approach to drug discoveryGerald J. Wyckoff, Lee Likins, Ubadah Sabbagh, Andrew SkaffA12 Challenges and opportunities for data applications in animal health: from precision medicine to precision husbandryAmado S. GuloyA13 A cloud-based programmable platform for healthHarlen D. HaysA14 Comparative oncology: One Health in actionAmy K. LeBlancA15 Companion animal diseases bridge the translational gap for human neurodegenerative diseaseJoan R. Coates, Martin L. Katz, Leslie A. Lyons, Gayle C. Johnson, Gary S. Johnson, Dennis P. O'BrienA16 Duchenne muscular dystrophy gene therapyDongsheng DuanA17 Polycystic kidney disease: cellular mechanisms to emerging therapiesJames P. CalvetA18 The domestic cat as a large animal model for polycystic kidney diseaseLeslie A. Lyons, Barbara GandolfiA19 The support of basic and clinical research by the Polycystic Kidney Disease FoundationDavid A. BaronA20 Using naturally occurring large animal models of human disease to enable clinical translation: treatment of arthritis using autologous stromal vascular fraction in dogsMark L. WeissA21 Regulatory requirements regarding clinical use of human cells, tissues, and tissue-based productsDebra A. WebsterA22 Regenerative medicine approaches to Type 1 diabetes treatmentFrancis N. KaranuA23 The zoobiquity of canine diabetes mellitus, man's best friend is a friend indeed-islet transplantationEdward J. RobbA24 One Medicine: a development model for cellular therapy of diabetesRobert J. Harman

    Boston University Concert Choir: "An Evening of American Song," March 1, 1992

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    This is the concert program of the Boston University Concert Choir performance on Sunday, March 1, 1992 at 7:30 p.m., at the Concert Hall, 855 Commonwealth Avenue. Works performed were Memories: A) Very Pleasant; B) Rather Sad by Charles Ives, Green Finch and Linnet Bird by Stephen Sondheim, Lullaby by Giancarlo Menotti, The Daisies by Samuel Barber, Rain Has Fallen by S. Barber, The Bird by Jon Duke, "Candide's Lament" from "Candide" by Leonard Bernstein, Sweet Suffolk Owl by Richard Hundley, "Laurie's Song" from "The Tender Land" by Aaron Copland, "Plum Pudding" from "Four Recipes" by L. Bernstein, Sam Was a Man by Vincent Persichetti, Sure on This Shining Night by S. Barber, Glory to God n the Highest by Randall Thompson, The Lobster Quadrille, The Lullaby of the Duchess, and Father William fron "Alice in Wonderland" by Irving Fine, The Road Note Taken and Choose Something Like a Star from "Frostiana" by R. Thompson, and Circus BAnd by C. Ives. Digitization for Boston University Concert Programs was supported by the Boston University Humanities Library Endowed Fund

    Modeling and simulation of fructo-oligosaccharides production

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    It is foreseen that Systems Biology will have a great impact not only in Metabolic Engineering and Drug Discovery efforts, but also in Bioprocess development and optimization. In fact, the computational tools developed in this area made possible to simulate a biochemical process with a mathematical model comprising dynamical equations based on first principles as well as empirical kinetic equations and parameters that can be estimated from experimental data. Fructo-oligosaccharides (FOS) have become important as healthy food ingredients because of their beneficial characteristics to the health of human (Lee, 1999). They can be obtained biotechnologically using the enzyme Betafructofuranosidase, produced by some fungi. The main purpose of this work was to develop a mathematical model able to simulate the formation of FOS in a bioreactor, in order to perform a faster optimization of the FOS production process, allowing to identify which parameters can influence the final amount of FOS. An empirical model presented by Kow Jen Duan et al (1994) was used to obtain the first set of reactions. Several hydrolysis equations were added in order to achieve a general mathematical model of the occurring enzymatic reactions. After the reformulation of the Kow Jen Duan model, the kinetic parameters were determined from experimental data using the System Biology toolbox [2] with the Simulated Annealing method for curve fitting. Several experiments in bioreactors were performed with two different FOS producing fungi for that purpose. The time evolution of 7 state variables (Sucrose, Glucose, Fructose, 1-Kestose, Nystose, 1-Fructosyl Nystose and Biomass) was considered. After parameter fitting, several simulations were performed in MatLab and the simulation results were compared with experimental data, exhibiting a very satisfactory correlation for both fungal cultures. Correlation coefficients of 0.9980 - 0.9549 between simulated and experimental data were obtained. This model will be used to optimize the production process, using an optimization tool that has been developed in our research group

    Baroque Chamber Music Concert, April 30, 1992

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    This is the concert program of the Baroque Chamber Music Concert on Thursday, April 30, 1992 at 8:30 p.m., at the Marshall Room, 855 Commonwealth Avenue. Works performed were QUartet in G minor by Georg Phillipp Telemann, Trio Sonata in D minor by George Frideric Handel, Cantata, "Ich Suchte des Nachts" by Dietrich Buxtehude, If Music Be The Food of Love by Henry Purcell, Lamento d'Arianna by Claudio Monteverdi, O come sei gentile by C. Monteverdi, and Quartet in G major by G. P. Telemann. Digitization for Boston University Concert Programs was supported by the Boston University Humanities Library Endowed Fund